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  4. FCGRT-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His)

FCGRT-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His)

Cat. No.: HY-P701255
Handling Instructions

The FCGRT protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. It binds IgG at the intestinal epithelium and forms an FcRn-IgG complex that is transcytosed across the epithelium, releasing IgG into the blood or tissue. FCGRT-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing human-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with Strep, His labeled tag. FCGRT-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His), has molecular weight of ~33 kDa(FCGRT) & 13 kDa(B2M), respectively.

For research use only. We do not sell to patients.

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Description

The FCGRT protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. It binds IgG at the intestinal epithelium and forms an FcRn-IgG complex that is transcytosed across the epithelium, releasing IgG into the blood or tissue. FCGRT-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing human-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with Strep, His labeled tag. FCGRT-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His), has molecular weight of ~33 kDa(FCGRT) & 13 kDa(B2M), respectively.

Background

FCGRT, a crucial cell surface receptor, facilitates the transfer of passive humoral immunity from the mother to the newborn by binding to the Fc region of monomeric immunoglobulin gamma and selectively mediating its uptake from milk. The process involves IgG binding at the apical surface of the intestinal epithelium, forming FcRn-IgG complexes that transcytose across the intestinal epithelium, releasing IgG into blood or tissue fluids. Beyond infancy, FCGRT plays a pivotal role in effective humoral immunity by recycling IgG and prolonging its half-life in the circulation. Mechanistically, the binding of monomeric IgG to FCGRT in acidic endosomes of endothelial and hematopoietic cells facilitates the recycling of IgG to the cell surface, subsequently releasing it into circulation. Additionally, FCGRT regulates the homeostasis of albumin/ALB, the other most abundant circulating protein, further underscoring its essential role in immune and protein homeostasis. In the context of microbial infection, FCGRT acts as an uncoating receptor for various echoviruses, including Echovirus 5, 6, 7, 9, 11, 13, 25, and 29.

Species

Human

Source

HEK293

Tag

Strep;His

Accession

P55899 (A24-S297)&P61769 (I21-M119)

Gene ID

2217&567

Synonyms
FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M
Molecular Weight

Approximately 33 kDa(FCGRT)&13 kDa(B2M)

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

FCGRT-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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FCGRT-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His)
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HY-P701255
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