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Results for "

130065-61-1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-110102
    Atiprimod hydrochloride

    SKF 106615

    		 JAK Inflammation/Immunology Cancer
    Atiprimod hydrochloride (SKF 106615) is an orally active immunomodulatory agent that causes phospholipid (PL) accumulation in macrophages .
    Atiprimod hydrochloride
  • HY-13559
    Atiprimod

    Azaspirane

    		 Apoptosis Cancer
    Atiprimod (Azaspirane) is an orally bioavailable small molecule with antitumor, anti-inflammatory, and anti-angiogenic activities. Atiprimod blocks the signaling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) by inhibiting the phosphorylation of signal transducer and activator of transcription 3 (STAT3). Atiprimod also downregulates the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis. Atiprimod triggers persistent ER stress-mediated apoptosis in breast cancer cells by activating the PERK/eIF2α/ATF4/CHOP axis and inhibiting the nuclear translocation of STAT3/NF-κB transcription factors .
    Atiprimod

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