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161302-93-8

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14829
    Afegostat

    D-Isofagomine; Isofagomine

    		 Glucosidase Neurological Disease
    Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity .
    Afegostat
  • HY-14829A
    Afegostat hydrochloride

    D-Isofagomine hydrochloride; Isofagomine hydrochloride

    		 Others Glucosidase Metabolic Disease
    Afegostat hydrochloride (D-Isofagomine hydrochloride) is a potent β-galactosidase inhibitor with activity ameliorating GM1-gangliosidosis and Morquio B disease-associated mutations. Afegostat hydrochloride is able to induce the maturation of mutant β-galactosidase in fibroblasts from patients with GM1-gangliosidosis. Afegostat hydrochloride also promotes the reduction of keratin sulfate and oligosaccharide load in patient cells .
    Afegostat hydrochloride
  • HY-14829H
    Afegostat TFA

    		Glucosidase Neurological Disease
    Afegostat TFA is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity .
    Afegostat TFA

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