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Bronchodilator

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By Targets:	Adenosine Receptor (9) Adrenergic Receptor (31) Apoptosis (1) Dopamine Receptor (1) Endogenous Metabolite (6) HDAC (3) Isotope-Labeled Compounds (1) mAChR (6) Phosphodiesterase (PDE) (12) Potassium Channel (2) Prostaglandin Receptor (1) Protein Arginine Deiminase (3) TRP Channel (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (25) Endocrinology (13) Infection (2) Inflammation/Immunology (36) Metabolic Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1209

Etofylline 7-(β-Hydroxyethyl)theophylline	Phosphodiesterase (PDE)	Cardiovascular Disease Inflammation/Immunology
Etofylline (7-(β-Hydroxyethyl) theophylline) is an oral bronchodilator with anti-inflammatory effects. Etofylline inhibits phosphodiesterase and prevents the degradation of cAMP (cyclic adenosine monophosphate), leading to smooth muscle relaxation, reducing inflammatory responses and improving respiratory function. Etofylline affects the development of zebrafish embryos .

HY-121043A

AA 497	Others	Inflammation/Immunology
AA 497 is a bronchodilator .

HY-121043

AA 497 free base	Others	Inflammation/Immunology
AA 497 free base is a bronchodilator .

HY-117928

BRL 55834	Potassium Channel	Cardiovascular Disease
BRL 55834 is an orally and potent potassium channel activator. BRL 55834 exhibits great bronchodilator potency but reduces tendency to lower arterial blood pressure. BRL 55834 has the potential to use as a bronchodilator .

HY-108030

Bencycloquidium bromide	mAChR	Neurological Disease Inflammation/Immunology Cancer
Bencycloquidium bromide, a muscarinic M(3) receptor antagonist, is an anticholinergic compound that acts as an anticholinergic bronchodilator. Bencycloquidium bromide can be used in the study for rhinitis .

HY-114630

Protokylol Caytine; JB-251	TRP Channel Adrenergic Receptor	Cardiovascular Disease
Protokylol (Caytine; JB-251) is a beta-adrenergic receptor agonist and TRPV1 agonist. Protokylol is used as a bronchodilator .

HY-100704A

(Rac)-Procaterol hydrochloride	Adrenergic Receptor	Inflammation/Immunology
(Rac)-Procaterol hydrochloride is a selective, orally active agonist at β2-adrenoceptor. (Rac)-Procaterol hydrochloride is used as a bronchodilator .

HY-B1481B

Isoetharine hydrochloride Isoetarine hydrochloride	Others	Infection
Isoetharine hydrochloride is selective, short-acting and orally active β-agonist which is widely used as a bronchodilator in the research of inhalation research .

HY-16413

Protokylol hydrochloride Caytine hydrochloride; JB-251 hydrochloride	TRP Channel Adrenergic Receptor	Others
Protokylol hydrochloride (Caytine hydrochloride; JB-251 hydrochloride) is the hydrochloride salt form of Protokylol (HY-114630). Protokylol hydrochloride is an agonist for β2-adrenergic receptor and TRPV1. Protokylol hydrochloride exhibits activity as a bronchodilator .

HY-105647

Ambuphylline Bufylline	Phosphodiesterase (PDE)	Cardiovascular Disease
Ambuphylline (Bufylline) is a *bronchodilator. Ambuphylline is a theophylline derivative possibly acting through phosphodiesterase* inhibition. Ambuphylline can be used for the research of asthma and other lung diseases .

HY-106306

Laprafylline S 9795	Phosphodiesterase (PDE)	Cardiovascular Disease
Laprafylline (S 9795), a xanthine derivative, is a bronchodilator. Laprafylline has potent anti-bronchoconstrictive effects, inhibiting action on mast cell degranulation and phosphodiesterase (PDE) activity (IC₅₀ of 6 μM) .

HY-B1505

Acefylline 1 Publications Verification Theophyllineacetic acid; Theophylline-7-acetic acid	HDAC Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)	Cardiovascular Disease
Acefylline, a xanthine derivative, is an adenosine receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research .

HY-B1675A

Levalbuterol hydrochloride (R)-Albuterol hydrochloride; (R)-Salbutamol hydrochloride; Levosalbutamol hydrochloride	Adrenergic Receptor	Inflammation/Immunology
Levalbuterol ((R)-Albuterol) hydrochloride is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol hydrochloride is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD .

HY-B1675

Levalbuterol (R)-Albuterol; (R)-Salbutamol; Levosalbutamol	Adrenergic Receptor	Inflammation/Immunology
Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD .

HY-108353

Isoprenaline	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Isoprenaline is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-110011

Cromakalim 1 Publications Verification BRL 34915	Potassium Channel	Inflammation/Immunology
Cromakalim is a potassium channel opener. Cromakalim can be used as a bronchodilator in asthma. Cromakalim inhibits the spontaneous tone of human isolated bronchi in a concentration-related manner being nearly as effective as isoprenaline or theophylline .

HY-B0468

Isoprenaline hydrochloride Maximum Cited Publications 51 Publications Verification Isoproterenol hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B0976

Fenoterol Th-1165; Phenoterol	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Fenoterol (Th-1165), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research .

HY-108353A

Isoprenaline hemisulfate	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Isoprenaline hemisulfate is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B1505R

Acefylline (Standard)	HDAC Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)	Others
Acefylline (Standard) is the analytical standard of Acefylline. This product is intended for research and analytical applications. Acefylline, a xanthine derivative, is an adenosine receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research .

HY-124950A

(+)-Picumeterol (+)-GR114297A	Others	Metabolic Disease
(+)-Picumeterol is a configurations of Picumeterol (HY-124950). Picumeterol is a potent and selective β₂-adrenoceptor agonist with bronchodilator and anti-bronchoconstrictor effects .

HY-B0976A

Fenoterol hydrobromide Th-1165a; Phenoterol hydrobromide	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research .

HY-B1675AR

Levalbuterol hydrochloride (Standard)	Adrenergic Receptor	Inflammation/Immunology
Levalbuterol (hydrochloride) (Standard) is the analytical standard of Levalbuterol (hydrochloride). This product is intended for research and analytical applications. Levalbuterol ((R)-Albuterol) hydrochloride is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol hydrochloride is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD .

HY-B0468R

Isoprenaline hydrochloride (Standard)	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Isoprenaline (hydrochloride) (Standard) is the analytical standard of Isoprenaline (hydrochloride). This product is intended for research and analytical applications. Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B1481

Isoetharine mesylate Isoetarine mesylate	Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology
Isoetharine (Isoetarine) mesylate is an orally active selective agonist of β-adrenergic receptors. Isoetharine mesylate is a catechol-like agent and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine mesylate can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator .

HY-B1481A

Isoetharine Isoetarine	Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology
Isoetharine (Isoetarine) is an orally active selective agonist of β-adrenergic receptors. Isoetharine is a catechol-like agent and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator .

HY-B1615

Clenbuterol NAB-365	Adrenergic Receptor	Inflammation/Immunology
Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC₅₀ of 31.9 nM . Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator .

HY-124950

Picumeterol GR114297A	Adrenergic Receptor	Others
Picumeterol (GR114297A) is a potent and selective β₂-adrenoceptor agonist with bronchodilator and anti-bronchoconstrictor effects. Picumeterol produces long-lasting relaxation of airways smooth muscle both in vitro and in vivo. Picumeterol is cleared from plasma through a rapid and extensive hepatic metabolism. Picumeterol is proming for rasearch of asthma and related diseases .

HY-159686

Aclidinium	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Aclidinium is a long-acting muscarinic antagonist and long-acting β₂-adrenoceptor (β₂-AR) agonist with bronchodilator activity. Aclidinium can reduce hyperinflation of the lungs and increase lung function and exercise endurance time. Aclidinium is used in research on chronic obstructive pulmonary disease (COPD) .

HY-15485

Zardaverine	Phosphodiesterase (PDE) Apoptosis	Inflammation/Immunology Cancer
Zardaverine is an orally active and selective PDE3/4 inhibitor (IC₅₀)=0.58 uM/0.17 uM) with potent bronchodilator activity. Zardaverine also selectively inhibits the proliferation of HCC cells and induces apoptosis and cycle arrest (G0/G1 phase). Zardaverine has good antitumor potential and is effective in both bronchial relaxation and reduction of inflammation in asthma .

HY-121985

Protheobromine	Others	Cardiovascular Disease
Protheobromine is a cardiotonic and bronchodilator

HY-19905

GW-597901	Others	Others
GW-597901 is a compound with bronchodilator activity that has a stronger bronchodilator effect than salbutamol in a human lung reperfusion model, but with a slightly slower onset of action.

HY-B1105A

Ethylnorepinephrine hydrochloride Etanor hydrochloride; Butanephrine hydrochloride	Others	Cardiovascular Disease
Ethylnorepinephrine hydrochloride is a sympathomimetic and bronchodilator related to norepinephrine.

HY-100194

FKK	Others	Cardiovascular Disease Inflammation/Immunology
FKK is an indazole derivative and also a novel bronchodilator.

HY-123208

Sulfonterol	Others	Inflammation/Immunology
Sulfonterol is a benzenemethanol derivative. Sulfonterol is a Bronchodilator .

HY-100250

Spirofylline	Others	Inflammation/Immunology
Spirofylline is a bronchodilator that has the potential for asthma and bronchitis and emphysema treatment.

HY-B1742

Proxyphylline	Phosphodiesterase (PDE) Adenosine Receptor	Cardiovascular Disease
Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator .

HY-B1694

Methoxyphenamine NSC-65644 free base	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Methoxyphenamine is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.

HY-B1694A

Methoxyphenamine hydrochloride NSC-65644	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Methoxyphenamine hydrochloride, a non-regulated analog of Methamphetamine, is a β-adrenergic receptor agonist used as a bronchodilator .

HY-U00105

Oxitropium Bromide	mAChR	Inflammation/Immunology
Oxitropium bromide is an mAChR antagonist used as an anticholinergic bronchodilator agent for the treatment of asthma and chronic obstructive pulmonary disease.

HY-16103

Bitolterol mesylate Win 32784; Bitolterol methanesulfonate; S-1540 mesylate	Others	Infection
Bitolterol mesylate (WIN 37284) is a diester-type agonist amine bronchodilator without significant cardiac side effects .

HY-118938

Hoquizil hydrochloride	Others	Cardiovascular Disease
Hoquizil hydrochloride is a novel bronchodilator with oral activity, demonstrating phosphodiesterase inhibitory effects and potential for modulation of smooth muscle contraction.

HY-19596

Fenprinast	Others	Inflammation/Immunology
Fenprinast is a cromotyn-like bronchodilator used for the research of allergy and exercise-induced asthma. Fenprinast has oral bioactivity .

HY-B1742R

Proxyphylline (Standard)	Adenosine Receptor	Cardiovascular Disease
Proxyphylline (Standard) is the analytical standard of Proxyphylline. This product is intended for research and analytical applications. Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator .

HY-129826

J-104129	mAChR	Others
J-104129 is a selective and orally active muscarinic M3 receptor antagonist (K_i = 4.2 nM). J-104129 is effective in promoting bronchodilation .

HY-A0225B

Pirbuterol dihydrochloride (±)-Pirbuterol(dihydrochloride); ARA 211(dihydrochloride)	Endogenous Metabolite	Cardiovascular Disease
Pirbuterol ((±)-Pirbuterol) dihydrochloride is a beta 2 adrenergic agonist with bronchodilator activity. Pirbuterol dihydrochloride is comparable in duration of action to albuterol when administered by inhalation. Pirbuterol dihydrochloride demonstrates similar beta 2 selectivity to albuterol in humans.

HY-B0140

Aminophylline 5+ Cited Publications	Phosphodiesterase (PDE) Adenosine Receptor	Inflammation/Immunology Cancer
Aminophylline is a competitive and non-selective phosphodiesterase (PDE) inhibitor. Aminophylline is a competitive adenosine receptor antagonist. Aminophylline has apulmonary vasodilator action as well as a bronchodilator action and has the potential for asthma research .

HY-B0128

Diphylline 1 Publications Verification Diprophylline	Adenosine Receptor Phosphodiesterase (PDE)	Cardiovascular Disease Inflammation/Immunology
Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema .

HY-14298

Milveterol hydrochloride GSK-159797C	Adrenergic Receptor	Endocrinology
Milveterol hydrochloride is a long-acting β2-adrenergic receptor agonist. Milveterol hydrochloride can be used in study asthma and chronic obstructive pulmonary disease (COPD) .

HY-A0267

Bitolterol	Others	Endocrinology
Bitolterol is a β2-adrenergic agonist with bronchodilator activity. Bitolterol is classified as a prodrug and is primarily used for the suppression of respiratory diseases. Bitolterol is considered safe for use during breastfeeding, as the amount that can enter breast milk is very limited .

Cat. No.	Product Name	Target	Research Area

HY-P3562

PL-3994	Peptides	Others
PL-3994 is a natriuretic peptide receptor-A (NPR-A) agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. PL-3994 produces concentration-dependent relaxation of pre-contracted guinea-pig trachea with an IC₅₀ value of 42.7 nM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1505

Acefylline 1 Publications Verification Theophyllineacetic acid; Theophylline-7-acetic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	HDAC Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)
Acefylline, a xanthine derivative, is an adenosine receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research .

HY-B0468

Isoprenaline hydrochloride Maximum Cited Publications 51 Publications Verification Isoproterenol hydrochloride	Cardiovascular Disease Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B1742

Proxyphylline	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Phosphodiesterase (PDE) Adenosine Receptor
Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator .

HY-B0140

Aminophylline 5+ Cited Publications	Classification of Application Fields Inflammation/Immunology Disease Research Fields	Phosphodiesterase (PDE) Adenosine Receptor
Aminophylline is a competitive and non-selective phosphodiesterase (PDE) inhibitor. Aminophylline is a competitive adenosine receptor antagonist. Aminophylline has apulmonary vasodilator action as well as a bronchodilator action and has the potential for asthma research .

HY-108353

Isoprenaline	Cardiovascular Disease Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Isoprenaline is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-108353A

Isoprenaline hemisulfate	Cardiovascular Disease Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Isoprenaline hemisulfate is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B1505R

Acefylline (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	HDAC Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)
Acefylline (Standard) is the analytical standard of Acefylline. This product is intended for research and analytical applications. Acefylline, a xanthine derivative, is an adenosine receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research .

HY-B0468R

Isoprenaline hydrochloride (Standard)	Structural Classification Alkaloids Other Alkaloids Source classification Phenols Polyphenols Endogenous metabolite	Adrenergic Receptor Endogenous Metabolite
Isoprenaline (hydrochloride) (Standard) is the analytical standard of Isoprenaline (hydrochloride). This product is intended for research and analytical applications. Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B1742R

Proxyphylline (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Adenosine Receptor
Proxyphylline (Standard) is the analytical standard of Proxyphylline. This product is intended for research and analytical applications. Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator .

Cat. No.	Product Name	Chemical Structure

HY-B0976AS

Fenoterol-d6 hydrobromide
Fenoterol-d₆ (hydrobromide) (Th-1165a-d6) is the deuterium labeled Fenoterol hydrobromide. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research[1][2].

HY-B0468S

Isoprenaline-d7 hydrochloride
Isoprenaline-d7 (hydrochloride) is a deuterated labeled Isoprenaline (hydrochloride) . Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

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Bronchodilator

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
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