2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor mAChR
  4. LAS190792

LAS190792 (AZD8999) is a potent muscarinic antagonist and β2-adrenoceptor agonist with pIC50 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6 for M1, M2, M3, M4, M5, β1, β2, β3, respectively. LAS190792 can be used as a bronchodilator.

For research use only. We do not sell to patients.

LAS190792 Chemical Structure

LAS190792 Chemical Structure

CAS No. : 1347232-69-2

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LAS190792 Related Antibodies

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α adrenergic receptor β adrenergic receptor

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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Description

LAS190792 (AZD8999) is a potent muscarinic antagonist and β2-adrenoceptor agonist with pIC50 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6 for M1, M2, M3, M4, M5, β1, β2, β3, respectively. LAS190792 can be used as a bronchodilator[1].

IC50 & Target

β1 adrenoceptor

7.5 (pIC50)

β2 adrenoceptor

9.1 (pIC50)

β3 adrenoceptor

5.6 (pIC50)

mAChR1

8.9 (pIC50)

mAChR2

8.8 (pIC50)

mAChR3

8.8 (pIC50)

mAChR4

9.2 (pIC50)

mAChR5

8.2 (pIC50)

Clinical Trial
Molecular Weight

811.36

Formula

C39H43ClN4O9S2
CAS No.
SMILES

COC(C=C(NC(OCCN(C)[C@@H]1CC[C@@H](OC(C(O)(C2=CC=CS2)C3=CC=CS3)=O)CC1)=O)C(Cl)=C4)=C4CNC[C@H](O)C5=CC=C(O)C(N6)=C5C=CC6=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LAS190792 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LAS1907921347232-69-2AZD8999LAS 190792LAS-190792AZD 8999AZD-8999Adrenergic ReceptormAChRBeta ReceptorMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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