Isoetharine  (Synonyms: Isoetarine)

Isoetharine (Isoetarine) is an orally active selective agonist of β-adrenergic receptors. Isoetharine is a catechol-like agent and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator^[1][2].

Isoetharine (50 μM, 18 hours) can induce the production and release of [³⁵S]sulfated metabolites of catecholic drugs in HepG2 human hepatoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isoetharine inhibits melanin deposition with the AC₅₀ value of 5.10 mM and complete inhibition of pigment production at 7.50 mM in the zebrafish larvae model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

239.31

C₁₃H₂₁NO₃

530-08-5

OC1=CC=C(C(O)C(NC(C)C)CC)C=C1O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Katsuhisa Kurogi，et al. Concerted actions of the catechol O-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs. Biochem Pharmacol. 2012 Nov 1;84(9):1186-95.  [Content Brief]

  [2]. Monika Maciag，et al. Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish. Toxicol Appl Pharmacol. 2022 Jan 1;434:115812.  [Content Brief]