1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Carmoterol

Carmoterol is a highly potent, selective and long-acting β2-adrenoceptor agonist with the pEC50 of 10.19. Carmoterol has 53 times higher affinity for the β2-adrenoceptors than for the β1-adrenoceptors. Carmoterol can be used for the research of asthma and chronic obstructive pulmonary disease (COPD).

For research use only. We do not sell to patients.

Carmoterol Chemical Structure

Carmoterol Chemical Structure

CAS No. : 147568-66-9

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Description

Carmoterol is a highly potent, selective and long-acting β2-adrenoceptor agonist with the pEC50 of 10.19. Carmoterol has 53 times higher affinity for the β2-adrenoceptors than for the β1-adrenoceptors[1][2]. Carmoterol can be used for the research of asthma and chronic obstructive pulmonary disease (COPD)[2].

In Vivo

Bronchoconstriction is induced in normal guinea-pigs by intravenous administration of graded doses of Acetylcholine (10, 20 and 40 mg/kg) and Histamine (5, 10 and 20 mg/kg) or in actively sensitized animals by Ovalbumin (5 mg/kg). Carmoterol (from 0.3 to 100 pmol) is given by superfusion onto the tracheal mucosa for 5 min before challenge. Carmoterol causes a dose-dependent inhibition of the acetylcholine-induced bronchoconstriction with the ED50 of 16.7 pmol[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Dunkin Hartley guinea-pigs (weighing 360-380 g)[2]
Dosage: 0.3 to 100 pmol.
Administration: Given by superfusion (0.01 mL/min) onto the tracheal mucosa for 5 min before challenge.
Result: Caused a dose-dependent inhibition of the Acetylcholine-induced bronchoconstriction.
Was very potent against Histamine and Ovalbumin-induced reaction, being effective already at 1 pmol.
Molecular Weight

368.43

Formula

C21H24N2O4

CAS No.
SMILES

O=C1NC2=C(C([C@@H](O)CN[C@H](C)CC3=CC=C(OC)C=C3)=CC=C2O)C=C1

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Carmoterol
Cat. No.:
HY-12463A
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