Fenoterol-d₆ hydrobromide

Cat. No.: HY-B0976AS: FAQs
Data Sheet SDS COA Handling Instructions

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Fenoterol-d₆ (hydrobromide) (Th-1165a-d6) is the deuterium labeled Fenoterol hydrobromide. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research[1][2].

For research use only. We do not sell to patients.

Fenoterol-d<sub>6</sub> hydrobromide Chemical Structure

Fenoterol-d₆ hydrobromide Chemical Structure

CAS No. : 1286129-04-1

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1 mg	USD 760	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Fenoterol-d₆ hydrobromide:

Fenoterol hydrobromide Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

390.30

Formula

C₁₇H₁₆D₆BrNO₄

CAS No.

1286129-04-1

Unlabeled CAS

1944-12-3

Appearance

Solid

Color

Off-white to light green

SMILES

OC(C=C1)=CC=C1C([2H])([2H])C(C([2H])([2H])[2H])([2H])NCC(C2=CC(O)=CC(O)=C2)O.Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (256.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 25 mg/mL (64.05 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5621 mL	12.8107 mL	25.6213 mL
5 mM	0.5124 mL	2.5621 mL	5.1243 mL
10 mM	0.2562 mL	1.2811 mL	2.5621 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 95.32%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. R C Heel, et al. Fenoterol: a review of its pharmacological properties and therapeutic efficacy in asthma. Drugs. 1978 Jan;15(1):3-32. [Content Brief]

[3]. Wei Wang, et al. Anti-inflammatory activities of fenoterol through β-arrestin-2 and inhibition of AMPK and NF-κB activation in AICAR-induced THP-1 cells. Biomed Pharmacother. 2016 Dec;84:185-190. [Content Brief]

[4]. Nada Choucair-Jaafar, et al. Beta2-adrenoceptor agonists alleviate neuropathic allodynia in mice after chronic treatment. Br J Pharmacol. 2009 Dec;158(7):1683-94. [Content Brief]

[5]. Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.5621 mL	12.8107 mL	25.6213 mL	64.0533 mL
	5 mM	0.5124 mL	2.5621 mL	5.1243 mL	12.8107 mL
	10 mM	0.2562 mL	1.2811 mL	2.5621 mL	6.4053 mL
	15 mM	0.1708 mL	0.8540 mL	1.7081 mL	4.2702 mL
	20 mM	0.1281 mL	0.6405 mL	1.2811 mL	3.2027 mL
	25 mM	0.1025 mL	0.5124 mL	1.0249 mL	2.5621 mL
	30 mM	0.0854 mL	0.4270 mL	0.8540 mL	2.1351 mL
	40 mM	0.0641 mL	0.3203 mL	0.6405 mL	1.6013 mL
	50 mM	0.0512 mL	0.2562 mL	0.5124 mL	1.2811 mL
	60 mM	0.0427 mL	0.2135 mL	0.4270 mL	1.0676 mL
DMSO	80 mM	0.0320 mL	0.1601 mL	0.3203 mL	0.8007 mL
DMSO	100 mM	0.0256 mL	0.1281 mL	0.2562 mL	0.6405 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.