2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Levalbuterol hydrochloride

Levalbuterol hydrochloride  (Synonyms: (R)-Albuterol hydrochloride; (R)-Salbutamol hydrochloride; Levosalbutamol hydrochloride)

Cat. No.: HY-B1675A Purity: 99.93%
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Levalbuterol ((R)-Albuterol) hydrochloride is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol hydrochloride is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD.

For research use only. We do not sell to patients.

Levalbuterol hydrochloride Chemical Structure

Levalbuterol hydrochloride Chemical Structure

CAS No. : 50293-90-8

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25 mg USD 210 In-stock
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100 mg USD 540 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Levalbuterol hydrochloride:

Levalbuterol hydrochloride Related Antibodies

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α adrenergic receptor β adrenergic receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Levalbuterol ((R)-Albuterol) hydrochloride is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol hydrochloride is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1].

IC50 & Target

β adrenergic receptor

 

In Vitro

Levalbuterol (10 μM; 24 hours) hydrochloride induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2expression in airway epithelial cells[1].
Levalbuterol (10 μM; 24 hours) hydrochloride significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Levalbuterol hydrochloride Related Antibodies

RT-PCR[1]

Cell Line: Murine Club (MTCC) cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Increased 11β-HSD1 mRNA expression selectively.
In Vivo

Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) hydrochloride significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 female mice with a pulmonary allergic model[2]
Dosage: 1 mg/kg
Administration: Subcutaneous injection; 1 mg/kg; 14 days
Result: Decreased pulmonary inflammation after OVA sensitization.
Clinical Trial
Molecular Weight

275.77

Formula

C13H22ClNO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)(NC[C@@H](C1=CC=C(C(CO)=C1)O)O)C.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (362.62 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6262 mL 18.1311 mL 36.2621 mL
5 mM 0.7252 mL 3.6262 mL 7.2524 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (362.62 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.6262 mL 18.1311 mL 36.2621 mL 90.6553 mL
5 mM 0.7252 mL 3.6262 mL 7.2524 mL 18.1311 mL
10 mM 0.3626 mL 1.8131 mL 3.6262 mL 9.0655 mL
15 mM 0.2417 mL 1.2087 mL 2.4175 mL 6.0437 mL
20 mM 0.1813 mL 0.9066 mL 1.8131 mL 4.5328 mL
25 mM 0.1450 mL 0.7252 mL 1.4505 mL 3.6262 mL
30 mM 0.1209 mL 0.6044 mL 1.2087 mL 3.0218 mL
40 mM 0.0907 mL 0.4533 mL 0.9066 mL 2.2664 mL
50 mM 0.0725 mL 0.3626 mL 0.7252 mL 1.8131 mL
60 mM 0.0604 mL 0.3022 mL 0.6044 mL 1.5109 mL
80 mM 0.0453 mL 0.2266 mL 0.4533 mL 1.1332 mL
100 mM 0.0363 mL 0.1813 mL 0.3626 mL 0.9066 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Levalbuterol hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Levalbuterol50293-90-8(R)-Albuterol(R)-SalbutamolLevosalbutamolAdrenergic ReceptorBeta Receptorasthmachronicobstructive pulmonaryCOPDbronchodilatorInhibitorinhibitorinhibit

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