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Glutathione Peroxidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glutathione Peroxidase (12) Apoptosis (4) Autophagy (1) Calcium Channel (1) Endogenous Metabolite (5) Ferroptosis (12) HIV (1) Interleukin Related (1) Mitochondrial Metabolism (1) p62 (1) Phosphatase (1) PROTACs (1) Reactive Oxygen Species (1) STING (1) TNF Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (15) Infection (1) Inflammation/Immunology (6) Metabolic Disease (2) Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: Glutathione Peroxidase Glutathione Reductase Glutathione S-transferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2833

**Glutathione Peroxidase** GSH-Px; EC 1.11.1.9	Glutathione Peroxidase	Others
Glutathione Peroxidase (GSH-Px; EC 1.11.1.9) belongs to the peroxidase family and is commonly used in biochemical research. Glutathione Peroxidase can catalyze reduced glutathione (GSH) to form a disulfide bridge with another glutathione molecule, convert it into oxidized glutathione (GSSG), and react with hydrogen peroxide or lipid peroxide reaction, reducing it to H₂O. Glutathione Peroxidase is an effective antioxidant against oxidative stress .

HY-139381

MitoEbselen-2 chloride MitoPeroxidase 2	Apoptosis	Metabolic Disease
MitoEbselen-2 chloride (MitoPeroxidase 2), a mitochondria-targeted mimic of glutathione peroxidase, is a radiation mitigator. MitoEbselen-2 chloride is effective in reducing lipid hydroperoxides, preventing apoptotic cell death .

HY-141809

GPX4-IN-3 1 Publications Verification	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM .

HY-100003

ML-210 10+ Cited Publications	Glutathione Peroxidase Ferroptosis	Cancer
ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC₅₀ of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity .

HY-B1000A

L-SelenoMethionine 2 Publications Verification	Endogenous Metabolite Apoptosis	Cancer
L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase .

HY-138153

JKE-1674 2 Publications Verification	Glutathione Peroxidase Ferroptosis	Cancer
JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of GPX4 inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors .

HY-13750

Ebselen 10+ Cited Publications SPI-1005; PZ-51; CCG-39161	Calcium Channel Virus Protease HIV Phosphatase	Infection Neurological Disease Inflammation/Immunology Cancer
Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker . Ebselen potently inhibits M ^pro (IC₅₀=0.67 μM) and COVID-19 virus (EC₅₀=4.67 μM) .Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity .

HY-W013754

S-Hexylglutathione	Others	Others
S-Hexylglutathione is an S-substituted glutathione in which the hydrogen of the thiol has been replaced by a hexyl group. S-Hexylglutathione is also an competitive inhibitor against *glutathione-S-transferase. S-Hexylglutathione can be used as an affinity chromatographic ligand for glutathione-S-transferase* and glutathione peroxidase .

HY-113402

Gamma-glutamylcysteine 1 Publications Verification γ-Glu-Cys	Endogenous Metabolite	Inflammation/Immunology
Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels .

HY-B1000AR

L-SelenoMethionine (Standard)	Endogenous Metabolite Apoptosis	Cancer
L-SelenoMethionine (Standard) is the analytical standard of L-SelenoMethionine. This product is intended for research and analytical applications. L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase .

HY-100002

ML162 5+ Cited Publications	Glutathione Peroxidase Ferroptosis	Cancer
ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines

HY-113402R

Gamma-glutamylcysteine (Standard)	Endogenous Metabolite	Inflammation/Immunology
Gamma-glutamylcysteine (Standard) is the analytical standard of Gamma-glutamylcysteine. This product is intended for research and analytical applications. Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels .

HY-139008

RC363	Others	Others
RC363 is a novel probucol analog with the activity to protect mouse hippocampal cells and primary cortical neurons from glutamate-induced oxidative cell death (ferroptosis) and increase glutathione peroxidase (GPx) 1 levels and activity.

HY-139012

RC574	Others	Others
RC574 is a novel probucol analog with the activity to protect mouse hippocampal cells and primary cortical neurons from glutamate-induced oxidative cell death (ferroptosis) and increase glutathione peroxidase (GPx) 1 levels and activity.

HY-162944

NA-Ir	Ferroptosis Mitochondrial Metabolism STING Autophagy	Cancer
NA-Ir is a Ferroptosis inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H₂S levels .

HY-157762

GPX4-IN-9	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-9 (Compound A16) is a glutathione peroxidase 4 (GPX4) inhibitor that specifically targets GPX4 under both in vitro and in vivo conditions, inducing ferroptosis. GPX4-IN-9 exhibits cytotoxicity against pancreatic cancer cells and can be used in cancer research .

HY-113402A

Gamma-glutamylcysteine TFA 1 Publications Verification γ-Glutamylcysteine TFA	Interleukin Related TNF Receptor Endogenous Metabolite	Inflammation/Immunology
Gamma-glutamylcysteine (γ-Glutamylcysteine) TFA, an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine TFA also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β). Gamma-glutamylcysteine TFA attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes .

HY-N11849

Moracin N	Ferroptosis Glutathione Peroxidase	Neurological Disease
Moracin N is a ferroptosis inhibitor that can be isolated from mulberry leaf. Moracin N exerts neuroprotective activity through preventing from oxidative stress .

HY-115627

PKUMDL-LC-101-D04 2 Publications Verification GPX4-Activator-1d4	Glutathione Peroxidase	Inflammation/Immunology
PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a glutathione peroxidase 4 (GPX4) allosteric activator (pEC₅₀=4.7). PKUMDL-LC-101-D04 can inhibit ferroptosis and inflammation .

HY-100218A

RSL3 Maximum Cited Publications 233 Publications Verification (1S,3R)-RSL3	p62 Glutathione Peroxidase Ferroptosis Reactive Oxygen Species	Cancer
RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

HY-162106

PROTAC GPX4 degrader-2	Ferroptosis PROTACs Glutathione Peroxidase	Cancer
PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade **glutathione peroxidase 4 (GPX4), with the DC_{50, 48h} value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis**. PROTAC GPX4 degrader-2 has anti-proliferative effect .

HY-163506

Ebselen derivative 1	Apoptosis Ferroptosis	Others
Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss .

HY-N7384A

Vitamin B15 hemicalcium Pangamic Acid hemicalcium	Others	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Vitamin B15 (Pangamic Acid) hemicalcium is a natural, ubiquitously in plant seeds substance and can used be as an agent stimulating cellular respiration. Vitamin B15 hemicalcium contains D-gluconodimethyl amino acetic acid. Vitamin B15 hemicalcium is also a immune-correcting agent . Vitamin B15 hemicalcium can be used for wide range of diseases.

HY-155663

GPX4-IN-5	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-5 (Compound C18) is a GPX4 covalent inhibitor with an IC₅₀ value of 0.12 μM. GPX4-IN-5 (Compound C18) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) .

HY-155664

GPX4-IN-6	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC₅₀ value of 0.13 μM. GPX4-IN-6 (Compound C25) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) .

HY-100218C

(1R,3R)-RSL3	Others	Cancer
(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

Cat. No.	Product Name

HY-L051

Ferroptosis Compound Library	1,009 compounds
Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc. MCE carefully collected a unique collection of 1,009 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

Ferroptosis Compound Library

1,009 compounds

Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc.

MCE carefully collected a unique collection of 1,009 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

L-SelenoMethionine 2 Publications Verification	Structural Classification Microorganisms other families Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase .

Gamma-glutamylcysteine 1 Publications Verification γ-Glu-Cys	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels .

Gamma-glutamylcysteine TFA 1 Publications Verification γ-Glutamylcysteine TFA	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Interleukin Related TNF Receptor Endogenous Metabolite
Gamma-glutamylcysteine (γ-Glutamylcysteine) TFA, an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine TFA also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β). Gamma-glutamylcysteine TFA attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes .

Moracin N	Structural Classification Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	Ferroptosis Glutathione Peroxidase
Moracin N is a ferroptosis inhibitor that can be isolated from mulberry leaf. Moracin N exerts neuroprotective activity through preventing from oxidative stress .

L-SelenoMethionine (Standard)	Structural Classification Microorganisms other families Animals Ketones, Aldehydes, Acids Source classification Plants Endogenous metabolite	Endogenous Metabolite Apoptosis
L-SelenoMethionine (Standard) is the analytical standard of L-SelenoMethionine. This product is intended for research and analytical applications. L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase .

Gamma-glutamylcysteine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Gamma-glutamylcysteine (Standard) is the analytical standard of Gamma-glutamylcysteine. This product is intended for research and analytical applications. Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels .

Species:	Human (4) Pig (2)
Tag:	His (5) Myc (2) Fc (1)
Source:	HEK293 (1) E. coli Cell-free (1) P. pastoris (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P71739

	EGLP/GPX5 Protein, Pig (P.pastoris, Myc, His) GPX5; Epididymal secretory Glutathione Peroxidase; EGLP; Glutathione Peroxidase 5; GPx-5; GSHPx-5	Pig	P. pastoris
	EGLP/GPX5 may constitute a protective system similar to glutathione peroxidase, protecting sperm membrane lipids from peroxidative damage. Despite the limited enzyme activity, the protective effect suggests an effect beyond enzyme function. EGLP/GPX5 Protein, Pig (P.pastoris, Myc, His) is the recombinant pig-derived EGLP/GPX5 protein, expressed by P. pastoris , with N-His, C-Myc labeled tag.

HY-P75798

	GPX7 Protein, Human (HEK293, Fc) Glutathione Peroxidase 7; GPx-7; GSHPx-7; CL683; GPX6	Human	HEK293
	GPX7, a protein with catalase activity, is predicted to respond to oxidative stress. It is located in the endoplasmic reticulum and is expressed in various tissues, including placenta (RPKM 15.6) and thyroid (RPKM 9.2). This highlights the potential importance of GPX7 in antioxidative processes throughout the body. GPX7 Protein, Human (HEK293, Fc) is the recombinant human-derived GPX7 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71145

	PRDX6 Protein, Human (His) Peroxiredoxin-6; 1-Cys Peroxiredoxin; 1-Cys PRX; 24 kDa Protein; Acidic Calcium-Independent Phospholipase A2; aiPLA2; Antioxidant Protein 2; Liver 2D PAGE Spot 40; Non-Selenium Glutathione Peroxidase; NSGPx; Red Blood Cells Page Spot 12; PRDX6; AOP2; KIAA0106	Human	E. coli
	The PRDX6 protein is a thiol-specific peroxidase that plays a crucial role in cellular defense against oxidative stress. It catalyzes the reduction of hydrogen peroxide and various organic hydroperoxides to water and alcohols. PRDX6 Protein, Human (His) is the recombinant human-derived PRDX6 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PRDX6 Protein, Human (His) is 224 a.a., with molecular weight of 30-33 kDa.

HY-P72211

	EGLP/GPX5 Protein, Pig (His-Myc) GPX5Epididymal secretory Glutathione Peroxidase; EC 1.11.1.9; Epididymis-specific Glutathione Peroxidase-like protein; EGLP; Glutathione Peroxidase 5; GPx-5; GSHPx-5	Pig	E. coli
	EGLP/GPX5 may constitute a protective system similar to glutathione peroxidase, protecting sperm membrane lipids from peroxidative damage. Despite the limited enzyme activity, the protective effect suggests an effect beyond enzyme function. EGLP/GPX5 Protein, Pig (His-Myc) is the recombinant pig-derived EGLP/GPX5 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of EGLP/GPX5 Protein, Pig (His-Myc) is 198 a.a., with molecular weight of ~27.6 kDa.

HY-P702646

	GPX4 Protein, Human (U73S, His) PHGPx; Glutathione Peroxidase 4; GPx-4; GSHPx-4	Human	E. coli
	GPX4 Protein, Human (U73S, His) is the recombinant human-derived GPX4, expressed by E. coli , with N-6*His labeled tag. ,

HY-P702379

	MGST2 Protein, Human (Cell-Free, His) Microsomal Glutathione S-transferase 2; Glutathione Peroxidase MGST2; 1.11.1.-; Leukotriene C4 synthase MGST2; 4.4.1.20; Microsomal Glutathione S-transferase II; Microsomal GST-II	Human	E. coli Cell-free
	As a multifunctional enzyme, MGST2 protein catalyzes the synthesis of cyclic ADP-β-D-ribose (cADPR) from NAD(+) and subsequently hydrolyzes cADPR into ADP-D-ribose (ADPR). This dual function makes MGST2 a key player in regulating intracellular calcium mobilization, as cADPR acts as an endogenous second messenger that triggers the release of intracellular stored calcium. MGST2 Protein, Human (Cell-Free, His) is the recombinant human-derived MGST2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of MGST2 Protein, Human (Cell-Free, His) is 147 a.a., with molecular weight of 19.4 kDa.

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HY-P80692

	Glutathione Peroxidase 4 Antibody Phospholipid hydroperoxide Glutathione Peroxidase; mitochondrial; PHGPx; EC 1.11.1.12; Glutathione Peroxidase 4; GPx-4; GSHPx-4	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Glutathione Peroxidase 4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 22 kDa, targeting to Glutathione Peroxidase 4. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80410

	Glutathione Peroxidase 1 Antibody (YA404)	WB, ICC/IF, IP	Human, Rat
	Glutathione Peroxidase 1 Antibody (YA404) is a non-conjugated and Rabbit origined monoclonal antibody about 22 kDa, targeting to Glutathione Peroxidase 1. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Rat.

HY-P83478

	MGST3 Antibody (YA3223) Glutathione Peroxidase MGST3; LTC4 synthase MGST3; Microsomal GST-III	WB, IHC-P, IP	Human
	MGST3 Antibody (YA3223) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3223), targeting MGST3, with a predicted molecular weight of 17 kDa (observed band size: 17 kDa). MGST3 Antibody (YA3223) can be used for WB, IHC-P, IP experiment in human background.

HY-P82408

	Glutathione Peroxidase 2 Antibody (YA2153) GI GPx; GPRP; GPRP-2; GPx-GI; GPX2; GSHPx 2; GSHPx GI; GSHPx-2; GSHPx-GI	WB, IHC-P	Human
	Glutathione Peroxidase 2 Antibody (YA2153) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2153), targeting Glutathione Peroxidase 2, with a predicted molecular weight of 22 kDa (observed band size: 22 kDa). Glutathione Peroxidase 2 Antibody (YA2153) can be used for WB, IHC-P experiment in human background.

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