2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation Autophagy
  3. Ferroptosis Mitochondrial Metabolism STING Autophagy
  4. NA-Ir

NA-Ir is a Ferroptosis inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H2S levels.

For research use only. We do not sell to patients.

NA-Ir Chemical Structure

NA-Ir Chemical Structure

CAS No. : 3031762-97-4

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NA-Ir Related Antibodies

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Description

NA-Ir is a Ferroptosis inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H2S levels[1].

Molecular Weight

1138.04

Formula

C49H36F6IrN8O4P
CAS No.
SMILES

CC1=CC2=[N](C=C1)[Ir+3]34([C-]5=C(C=CC=C5)C6=CC=CC=[N]63)([C-]7=CC=CC=C7C8=[N]4C=CC=C8)[N]9=CC=C(COC(CCN%10C(C%11=C%12C(C%10=O)=CC=C(C%12=CC=C%11)N=[N+]=[N-])=O)=O)C=C29.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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NA-Ir Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NA-Ir3031762-97-4FerroptosisMitochondrial MetabolismSTINGAutophagyStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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