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  4. (1R,3R)-RSL3

(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells.

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(1R,3R)-RSL3 Chemical Structure

(1R,3R)-RSL3 Chemical Structure

CAS No. : 1219810-15-7

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(1R,3R)-RSL3 Related Antibodies

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Description

(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells[1].

Molecular Weight

440.88

Formula

C23H21ClN2O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C([C@H]1CC2=C([C@@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=C2C=CC=C4)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (226.82 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2682 mL 11.3410 mL 22.6819 mL
5 mM 0.4536 mL 2.2682 mL 4.5364 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2682 mL 11.3410 mL 22.6819 mL 56.7048 mL
5 mM 0.4536 mL 2.2682 mL 4.5364 mL 11.3410 mL
10 mM 0.2268 mL 1.1341 mL 2.2682 mL 5.6705 mL
15 mM 0.1512 mL 0.7561 mL 1.5121 mL 3.7803 mL
20 mM 0.1134 mL 0.5670 mL 1.1341 mL 2.8352 mL
25 mM 0.0907 mL 0.4536 mL 0.9073 mL 2.2682 mL
30 mM 0.0756 mL 0.3780 mL 0.7561 mL 1.8902 mL
40 mM 0.0567 mL 0.2835 mL 0.5670 mL 1.4176 mL
50 mM 0.0454 mL 0.2268 mL 0.4536 mL 1.1341 mL
60 mM 0.0378 mL 0.1890 mL 0.3780 mL 0.9451 mL
80 mM 0.0284 mL 0.1418 mL 0.2835 mL 0.7088 mL
100 mM 0.0227 mL 0.1134 mL 0.2268 mL 0.5670 mL
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(1R,3R)-RSL3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(1R,3R)-RSL31219810-15-7Others(1R,3R)-isomerInhibitorinhibitorinhibit

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