2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Gamma-glutamylcysteine

Gamma-glutamylcysteine  (Synonyms: γ-Glu-Cys)

Cat. No.: HY-113402 Purity: 95.20%
SDS COA Handling Instructions

Molarity Calculator

Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels.

For research use only. We do not sell to patients.

Gamma-glutamylcysteine Chemical Structure

Gamma-glutamylcysteine Chemical Structure

CAS No. : 636-58-8

Size Price Stock Quantity
5 mg USD 35 In-stock
10 mg USD 55 In-stock
25 mg USD 100 In-stock
50 mg USD 165 In-stock
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200 mg   Get quote  

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Based on 2 publication(s) in Google Scholar

Other Forms of Gamma-glutamylcysteine:

Gamma-glutamylcysteine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Co-treatment of Aβ40 oligomers with Gamma-glutamylcysteine (γ-Glutamylcysteine; GGC) at 200 μM increased the activity of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) and leads to significant increases in the levels of the total antioxidant capacity (TAC) and GSH and reduces the GSSG/GSH ratio. Gamma-glutamylcysteine also upregulates the level of the anti-inflammatory cytokine IL-10 and reduced the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gamma-glutamylcysteine Related Antibodies
Molecular Weight

250.27

Formula

C8H14N2O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

SC[C@@H](C(O)=O)NC(CC[C@H](N)C(O)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (399.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9957 mL 19.9784 mL 39.9568 mL
5 mM 0.7991 mL 3.9957 mL 7.9914 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (399.57 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 95.42%

SDS (762 KB)

COA (248 KB) HNMR (257 KB) RP-HPLC (249 KB) MS (69 KB) OR (170 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.9957 mL 19.9784 mL 39.9568 mL 99.8921 mL
5 mM 0.7991 mL 3.9957 mL 7.9914 mL 19.9784 mL
10 mM 0.3996 mL 1.9978 mL 3.9957 mL 9.9892 mL
15 mM 0.2664 mL 1.3319 mL 2.6638 mL 6.6595 mL
20 mM 0.1998 mL 0.9989 mL 1.9978 mL 4.9946 mL
25 mM 0.1598 mL 0.7991 mL 1.5983 mL 3.9957 mL
30 mM 0.1332 mL 0.6659 mL 1.3319 mL 3.3297 mL
40 mM 0.0999 mL 0.4995 mL 0.9989 mL 2.4973 mL
50 mM 0.0799 mL 0.3996 mL 0.7991 mL 1.9978 mL
60 mM 0.0666 mL 0.3330 mL 0.6659 mL 1.6649 mL
80 mM 0.0499 mL 0.2497 mL 0.4995 mL 1.2487 mL
100 mM 0.0400 mL 0.1998 mL 0.3996 mL 0.9989 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gamma-glutamylcysteine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gamma-glutamylcysteine636-58-8γ-Glu-CysEndogenous MetabolitedipeptideGSHcysteineglutamicacidGPxantioxidantanti-inflammatoryInhibitorinhibitorinhibit

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