2. Apoptosis Metabolic Enzyme/Protease PROTAC
  3. Ferroptosis Glutathione Peroxidase PROTACs
  4. PROTAC GPX4 degrader-2

PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade glutathione peroxidase 4 (GPX4), with the DC50, 48h value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. PROTAC GPX4 degrader-2 has anti-proliferative effect.

For research use only. We do not sell to patients.

PROTAC GPX4 degrader-2 Chemical Structure

PROTAC GPX4 degrader-2 Chemical Structure

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PROTAC GPX4 degrader-2 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade glutathione peroxidase 4 (GPX4), with the DC50, 48h value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. PROTAC GPX4 degrader-2 has anti-proliferative effect[1].

Molecular Weight

953.52

Formula

C50H61ClN8O9
SMILES

O=C(NCC1=CN(CCCCCCCC(N[C@@H]([C@H](O)C(N[C@@H](CC(C)C)C(OC)=O)=O)CC2=CC=CC=C2)=O)N=N1)C(C=C3)=CC=C3[C@H](N(C(CCl)=O)[C@@H](C(OC)=O)C4)C5=C4C6=CC=CC=C6N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC GPX4 degrader-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC GPX4 degrader-2FerroptosisGlutathione PeroxidasePROTACsHT1080 cellsRSL3Inhibitorinhibitorinhibit

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