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Results for "

Gram-negative pathogens

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminoacyl-tRNA Synthetase (3) Antibiotic (33) Bacterial (57) Beta-lactamase (5) Fungal (2) Toll-like Receptor (TLR) (1) TOPK (5)
By Research Areas:	Cancer (2) Infection (55) Inflammation/Immunology (10)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12479A

Epetraborole hydrochloride 2 Publications Verification GSK2251052 hydrochloride	Bacterial Aminoacyl-tRNA Synthetase	Infection
Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC₅₀=0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research .

HY-103251

PF-5081090 LpxC-4	Antibiotic Bacterial	Infection
PF-5081090 (LpxC-4) is a potent LpxC inhibitor, is a rapidly bactericidal with broad-spectrum activity. PF-5081090 serves as a regulator of lipid A biosynthesis in Gram-negative pathogens .

HY-106574A

Ceftobiprole medocaril sodium BAL5788 sodium	Bacterial	Infection Inflammation/Immunology
Ceftobiprole medocaril (BAL5788) sodium is the parenteral proagent of Ceftobiprole (HY-112579). Ceftobiprole is a parenteral pyrrolidinone cephalosporin. Ceftobiprole is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci. Ceftobiprole also inhibits gram-positive and gram-negative pathogens .

HY-139748

ETX0462	Antibiotic Bacterial	Infection
ETX0462 is a gram-negative chemotype antibiotic. ETX0462 has potent in vitro and in vivo activity against Pseudomonas aeruginosa plus all other Gram-negative ESKAPE pathogens, Stenotrophomonas maltophilia and biothreat pathogens .

HY-N12262

(+)-Epieudesmin	Bacterial	Infection Cancer
(+)-Epieudesmin is an antineoplastic agent. (+)-Epieudesmin has marginal cancer cell line inhibitory activities. (+)-Epieudesmin inhibits the growth of *Gram-negative* pathogen .

HY-12479

Epetraborole GSK-2251052; AN 3365	Bacterial Aminoacyl-tRNA Synthetase	Infection
Epetraborole (GSK2251052) is a leucyl-tRNA synthetase (LeuRS) inhibitor (*IC₅₀=0.31 μM), thereby inhibiting protein synthesis. Epetraborole can be used in multidrug-resistant gram-negative* pathogens infection research .**

HY-12479B

Epetraborole (R-mandelate) GSK-2251052 (R-mandelate); AN 3365 (R-mandelate)	Bacterial Aminoacyl-tRNA Synthetase	Infection
Epetraborole R-mandelate is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (*IC₅₀=0.31 μM), thereby inhibiting protein synthesis. Epetraborole R-mandelate can be used in multidrug-resistant gram-negative* pathogens infection research .**

HY-161689

Antibacterial agent 220	Bacterial	Infection
Antibacterial agent 220 is a potent antibacterial agent that can directly destroy bacterial cell membranes. Antibacterial agent 220 effectively combats Gram-positive and and Gram-negative pathogens, including drug-resistant strains .

HY-U00380

Tigemonam	Bacterial Antibiotic	Infection
Tigemonam is a monobactam, with potent activity against Gram-negative aerobic bacterial pathogens.

HY-106574

Ceftobiprole medocaril BAL5788	Bacterial	Infection Inflammation/Immunology
Ceftobiprole medocaril (BAL5788) is the parenteral proagent of Ceftobiprole (HY-112579). Ceftobiprole is a parenteral pyrrolidinone cephalosporin. Ceftobiprole is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci. Ceftobiprole also inhibits gram-positive and gram-negative pathogens .

HY-112579

Ceftobiprole 2 Publications Verification Ro 63-9141; BAL 9141	Bacterial Antibiotic	Infection Inflammation/Immunology
Ceftobiprole (Ro 63-9141) is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci with a MIC₉₀ value of 2 μg/mL for MRSA. Ceftobiprole also inhibits gram-positive and gram-negative pathogens. Ceftobiprole can be used for the study of hospital-acquired pneumonia (excluding ventilator-associated pneumonia) and community-acquired pneumonia .

HY-103095

Enmetazobactam 5 Publications Verification AAI101	Beta-lactamase Bacterial	Infection
Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens .

HY-103095A

Enmetazobactam iodide AAI101 iodide	Bacterial Antibiotic	Others
Enmetazobactam (iodide) (AAI101 (iodide)) is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens .

HY-16158

Cyclacillin Wy-4508; Aminocyclohexylpenicillin; Ciclacillin	Bacterial Antibiotic	Infection
Cyclacillin (Wy-4508) is an orally active aminopenicillin antibiotic, shows antibacterial activity against a wide range of gram-positive and gram-negative pathogens .

HY-164036

Lolamicin	Antibiotic Bacterial	Infection
Lolamicin is a Gram-negative specific antibiotic. Lolamicin is active against more than 130 multidrug-resistant clinical isolates, has shown efficacy in multiple mouse models of acute pneumonia and sepsis infection, and protects the gut microbiome of mice against secondary infection with Clostridium difficile. The selective killing of pathogenic gram-negative bacteria by Lolamicin is a result of the low sequence homology of pathogenic bacteria and symbiotic bacteria. Lolamicin can be used in the study of infection caused by Gram-negative pathogens .

HY-B0698

Ceftibuten Sch 39720	Beta-lactamase Bacterial Antibiotic	Infection
Ceftibuten (Sch39720), an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens .

HY-B0698B

Ceftibuten monohydrate Sch 39720 monohydrate	Beta-lactamase Bacterial Antibiotic	Infection
Ceftibuten (Sch39720) monohydrate, an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens .

HY-B2170

Octenidine	Bacterial	Infection
Octenidine is a potent antibacterial agent, possessing activity against multidrug-resistant Gram-negative pathogens. Octenidine can inhibit the expression of biofilm genes and destroy the formation of biofilms .

HY-136502

(E)-Aztreonam SQ-28429	Antibiotic Bacterial	Infection
(E)-Aztreonam (SQ-28429) is a monocyclic beta-lactam antibiotic. (E)-Aztreonam has the potential for the research of infections caused by gram-negative pathogens .

HY-B0698A

Ceftibuten dihydrate 1 Publications Verification Sch-39720 dihydrate	Beta-lactamase Bacterial Antibiotic	Infection
Ceftibuten (Sch-39720) dihydrate, an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens .

HY-B2170B

Octenidine (saccharin)	Bacterial	Infection
Octenidine saccharin is a potent antibacterial agent, possessing activity against multidrug-resistant Gram-negative pathogens. Octenidine saccharin can inhibit the expression of biofilm genes and destroy the formation of biofilms .

HY-P10519

Brevicidine	Bacterial	Infection
Brevicidine is a non-ribosomally synthesized antimicrobial peptide with potent antibacterial activity against Gram-negative pathogens. Brevicidine disrupts the morphology of bacteria by binding to polysaccharides (LPS) on bacterial cell membranes to form holes .

HY-128780

Upleganan SPR206	Bacterial	Infection Cancer
Upleganan (SPR206), a polymyxin analogue, and shows antibiotic activity against multidrug resistant **Gram-negative pathogen. The MIC values of Upleganan against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii** NCTC13301 are both 0.125 mg/L .

HY-167892

DRF-8417	Antibiotic Bacterial	Infection Inflammation/Immunology
DRF-8417, an oxazolidinone antibiotic, is active against Gram-positive and fastidious Gram-negative bacteria. DRF 8417 exhibits potent activity against Gram-positive pathogens with MIC₅₀ and MIC₉₀ values ranging from 0.06 to 1 mg/L .

HY-B0395

Sitafloxacin DU6859a	Bacterial Antibiotic	Infection
Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection .

HY-B0536

Clinafloxacin AM-1091; CI-960; PD 127391	Bacterial Antibiotic	Infection
Clinafloxacin (AM 1091) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro . Clinafloxacin is against DNA gyrase and topoisomerase IV of?S. aureus with IC₅₀ values of 0.92 μg/ml and 1.62 μg/ml, respectively .

HY-B0536A

Clinafloxacin hydrochloride AM 1091 hydrochloride; CI 960 hydrochloride; PD127391 hydrochloride	Bacterial Antibiotic	Infection
Clinafloxacin hydrochloride (AM 1091 hydrochloride) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro . Clinafloxacin hydrochloride is against DNA gyrase and topoisomerase IV of S. aureus with IC₅₀ values of 0.92 µg/ml and 1.62 µg/ml, respectively .

HY-B0395B

Sitafloxacin monohydrate DU6859a monohydrate	Bacterial Antibiotic	Infection
Sitafloxacin (DU6859a) monohydrate is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin monohydrate shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin monohydrate can be used for the research of respiratory tract infection and urinary tract infection .

HY-B0395A

Sitafloxacin hydrochloride DU6859a hydrochloride	Antibiotic Bacterial	Infection
Sitafloxacin (DU6859a) hydrochloride is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin hydrochloride shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin hydrochloride can be used for the research of respiratory tract infection and urinary tract infection .

HY-P1884

LL-37, acetylated,amidated	Bacterial	Infection
LL-37, acetylated, amidated is a cathelicidin peptide LL-37 acetylated on the N-terminus and amidated on the C-terminus. The single human cathelicidin peptide LL-37 has antimicrobial and anti-biofilm activity against multiple Gram-positive and Gram-negative human pathogens, and has wound-healing effects on the host .

HY-128780B

SPR206 acetate 1 Publications Verification	Bacterial Antibiotic	Infection
SPR206 acetate is a polymyxin analog with antibiotic activity against **Gram-negative pathogens, including multidrug-resistant (MDR) variants. SPR206 acetate has an anti-bacterial infection effect by interacting with the bacterium’s outer membrane. The MIC values of SPR206 acetate against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii** NCTC13301 are both 0.125 mg/L .

HY-111023

Nemonoxacin malate TG-873870 malate	Antibiotic Bacterial	Infection
Nemonoxacin (TG-873870) malate is a nonfluorinated quinolone antibiotic. Nemonoxacin malate has broad-spectrum activity against Gram-positive, Gram-negative and atypical pathogens. Nemonoxacin malate can inhibit drug-resistant Streptococcus pneumoniae and (HY-121544) Methicillin-resistant Staphylococcus aureus. Nemonoxacin malate can be used for the research of community-acquired pneumonia .

HY-B0536R

Clinafloxacin (Standard)	Bacterial Antibiotic	Infection
Clinafloxacin (Standard) is the analytical standard of Clinafloxacin. This product is intended for research and analytical applications. Clinafloxacin (AM 1091) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro . Clinafloxacin is against DNA gyrase and topoisomerase IV of S. aureus with IC₅₀ values of 0.92 µg/ml and 1.62 µg/ml, respectively .

HY-B1156

Cephradine 1 Publications Verification Cefradine; SQ-11436	Bacterial Antibiotic TOPK	Infection Inflammation/Immunology
Cephradine (Cefradine) is a broad-spectrum and orally active cephalosporin. Cephradine is active against both gram-positive and gram-negative pathogens. Cephradine is effective in eradicating most penicillinase-producing organisms. Cephradine has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK .

HY-B1156A

Cephradine sodium Cefradine sodium; SQ-11436 sodium	Bacterial Antibiotic TOPK	Infection Inflammation/Immunology
Cephradine sodium is a broad-spectrum and orally active cephalosporin. Cephradine sodium is active against both gram-positive and gram-negative pathogens. Cephradine sodium is effective in eradicating most penicillinase-producing organisms. Cephradine sodium has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine sodium blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK .

HY-14737A

Ceftaroline fosamil hydrate TAK-599 hydrate; PPI0903 hydrate	Antibiotic Bacterial	Infection
Ceftaroline fosamil hydrate is a potent cephalosporin antibiotic. Ceftaroline fosamil hydrateshows broad-spectrum activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Streptococcus pneumoniae, and common Gram-negative organisms. Ceftaroline fosamil hydrate has anti-infective activity, and can be used for the research of complicated skin and skin structure infections (cSSSIs) and community-acquired bacterial pneumonia (CABP) .

HY-113557

DNAC-1	Bacterial Antibiotic Beta-lactamase	Infection
DNAC-1 is a potent antibacterial agent. DNAC-1 enhances β-lactam activity against Gram positive and *Gram negative* pathogens .

HY-139554A

Zifanocycline TFA KBP-7072 TFA	Bacterial	Infection
Zifanocycline (KBP-7072) TFA is an orally active, semi-synthetic aminomethylcycline antibiotic that inhibits the normal function of bacterial ribosomes. Zifanocycline TFA has broad spectrum in vitro antimicrobial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens. Zifanocycline TFA is indicated for the study of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections .

HY-128449

Cephradine monohydrate Cefradine monohydrate	Bacterial Antibiotic TOPK	Infection Inflammation/Immunology
Cephradine (Cefradine) monohydrate is a broad-spectrum and orally active cephalosporin. Cephradine monohydrate is active against both grampositive and gram-negative pathogens and effective in eradicating most penicillinase-producing organisms known to be resistant to penicillin G, penicillin V, and ampicillin. Cephradine monohydrate has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine monohydrate blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK .

HY-139554

Zifanocycline KBP-7072	Bacterial	Infection
Zifanocycline (KBP-7072) is a semisynthetic third-generation aminomethylcycline antibiotic that inhibits the normal function of the bacterial ribosome. Zifanocycline exhibits a broad spectrum of in vitro antibacterial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens. Zifanocycline is available in both oral and injectable formulations. Zifanocycline can be used for the research of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections .

HY-105048A

Omiganan pentahydrochloride	Bacterial	Infection
Omiganan pentahydrochloride is a cationic peptide compound with a broad antibacterial profile. Omiganan pentahydrochloride is capable of inhibiting a variety of bacteria, including yeast, and is active against both gram-positive and gram-negative bacteria. Omiganan pentahydrochloride is able to interact with the bacterial cell membrane, causing the destruction of the cell membrane and the death of the bacteria. Omiganan pentahydrochloride can be used for the study of antimicrobial activity against pathogens commonly associated with catheter-associated infections, including strains with drug-resistant phenotypes .

HY-P10540

Pantinin-2	Bacterial	Infection
Pantinin-2 is a cysteine-free toxic peptide found in the emperor scorpion (paninus imperator). Pantinin-2 has high activity against Gram-positive bacteria but weak activity against Gram-negative bacteria. Pantinin-2 also exhibits activity against Candida tropicalis and has relatively mild hemolytic activity against human erythrocytes. Pantinin-2 can be used in the development of antimicrobial drugs for drug-resistant pathogens .

HY-155007

DNA gyrase B-IN-2	Bacterial	Infection
DNA gyrase B-IN-2 (Compound E) is a 2-aminobenzothiazole-based DNA gyrase B inhibitor with promising activity against ESKAPE bacterial pathogens. DNA gyrase B-IN-2 showed low nanomolar inhibition of DNA gyrase (IC₅₀ < 10 nM) and broad-spectrum antibacterial activity against pathogens belonging to the ESKAPE group, with the minimum inhibitory concentration < 0.03 μg/mL for most Gram-positive strains and 4–16 μg/mL against Gram-negative E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.DNA gyrase B-IN-2 can be used for the research of infection .

HY-B1156R

Cephradine (Standard)	Bacterial Antibiotic TOPK	Infection Inflammation/Immunology
Cephradine (Standard) is the analytical standard of Cephradine. This product is intended for research and analytical applications. Cephradine (Cefradine) is a broad-spectrum and orally active cephalosporin. Cephradine is active against both gram-positive and gram-negative pathogens. Cephradine is effective in eradicating most penicillinase-producing organisms. Cephradine has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK .

HY-113687

T145	Bacterial	Infection
T145 is an oxazolidinone with antibacterial activity that inhibits growth of gram negatives (K. pneumoniae, A. baumannii, P. aeruginosa and E. cloacae), gram positives (E. faecalis and S. aureus) and acid fast pathogens (Mab, Mav and Mtb) .

HY-P5484

SMAP-18	Bacterial	Others
SMAP-18 is a biological active peptide. (SMAP-18 is a 18-amino acid residue peptide amide which is a truncated form of SMAP-29. Sheep myeloid antimicrobial peptide-29 (SMAP-29) displays extremely high antimicrobial activity against Pseudomonas strains, other Gram-negative bacteria, and multidrug-resistant pathogens. SMAP-18 displays much higher cell selectivity as compared to parental SMAP-29 because of its decreased hemolytic activity and retained antimicrobial activity.)

HY-P5601

Thanatin	Bacterial Fungal	Infection
Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .

HY-128449R

Cephradine (monohydrate) (Standard)	Bacterial Antibiotic TOPK	Infection Inflammation/Immunology
Cephradine (monohydrate) (Standard) is the analytical standard of Cephradine (monohydrate). This product is intended for research and analytical applications. Cephradine (Cefradine) monohydrate is a broad-spectrum and orally active cephalosporin. Cephradine monohydrate is active against both grampositive and gram-negative pathogens and effective in eradicating most penicillinase-producing organisms known to be resistant to penicillin G, penicillin V, and ampicillin. Cephradine monohydrate has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine monohydrate blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK .

HY-P5601A

Thanatin TFA	Bacterial Fungal	Infection
Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .

HY-D1056H

Lipopolysaccharides, from S. marcescens LPS, from Serratia marcescens	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides, from S. marcescens, are lipopolysaccharide endotoxins that can activate pathogen-associated molecular patterns (PAMP) in the immune system and induce the secretion of exosomes by cells. Lipopolysaccharides can be extracted from the outer leaflet of the outer membrane of Gram-negative bacteria and consist of an O-specific antigen chain, a core oligosaccharide, and lipid A. Lipopolysaccharides, from S. marcescens, induce the activation of NF-κB in mouse cells through Toll-like receptor (TLR4)/MD-2. Lipopolysaccharides from S. marcescens can also induce apoptosis in host immune cellsS. marcescens .

Cat. No.	Product Name	Type

HY-D1056H

Lipopolysaccharides, from S. marcescens

LPS, from Serratia marcescens

Carbohydrates

Lipopolysaccharides, from S. marcescens, are lipopolysaccharide endotoxins that can activate pathogen-associated molecular patterns (PAMP) in the immune system and induce the secretion of exosomes by cells. Lipopolysaccharides can be extracted from the outer leaflet of the outer membrane of Gram-negative bacteria and consist of an O-specific antigen chain, a core oligosaccharide, and lipid A. Lipopolysaccharides, from S. marcescens, induce the activation of NF-κB in mouse cells through Toll-like receptor (TLR4)/MD-2. Lipopolysaccharides from S. marcescens can also induce apoptosis in host immune cellsS. marcescens .

Cat. No.	Product Name	Target	Research Area