2. Anti-infection
  3. Bacterial
  4. Zifanocycline TFA

Zifanocycline TFA  (Synonyms: KBP-7072 TFA)

Cat. No.: HY-139554A Purity: 99.79%
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Zifanocycline (KBP-7072) TFA is an orally active, semi-synthetic aminomethylcycline antibiotic that inhibits the normal function of bacterial ribosomes. Zifanocycline TFA has broad spectrum in vitro antimicrobial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens. Zifanocycline TFA is indicated for the study of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections.

For research use only. We do not sell to patients.

Zifanocycline TFA Chemical Structure

Zifanocycline TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 160 In-stock
5 mg USD 400 In-stock
10 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Zifanocycline TFA:

Zifanocycline TFA Related Antibodies

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Description

Zifanocycline (KBP-7072) TFA is an orally active, semi-synthetic aminomethylcycline antibiotic that inhibits the normal function of bacterial ribosomes. Zifanocycline TFA has broad spectrum in vitro antimicrobial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens. Zifanocycline TFA is indicated for the study of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections[1][2].

Molecular Weight

666.64

Formula

C31H37F3N4O9
Appearance

Solid

Color

Yellow to brown

SMILES

O[C@]12[C@](C[C@@]3([H])C(C(C4=C(O)C(CN5CC6C(C6)C5)=CC(N(C)C)=C4C3)=O)=C2O)([H])[C@@H](C(O)=C(C1=O)C(N)=O)N(C)C.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (187.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5001 mL 7.5003 mL 15.0006 mL
5 mM 0.3000 mL 1.5001 mL 3.0001 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5001 mL 7.5003 mL 15.0006 mL 37.5015 mL
5 mM 0.3000 mL 1.5001 mL 3.0001 mL 7.5003 mL
10 mM 0.1500 mL 0.7500 mL 1.5001 mL 3.7501 mL
15 mM 0.1000 mL 0.5000 mL 1.0000 mL 2.5001 mL
20 mM 0.0750 mL 0.3750 mL 0.7500 mL 1.8751 mL
25 mM 0.0600 mL 0.3000 mL 0.6000 mL 1.5001 mL
30 mM 0.0500 mL 0.2500 mL 0.5000 mL 1.2500 mL
40 mM 0.0375 mL 0.1875 mL 0.3750 mL 0.9375 mL
50 mM 0.0300 mL 0.1500 mL 0.3000 mL 0.7500 mL
60 mM 0.0250 mL 0.1250 mL 0.2500 mL 0.6250 mL
80 mM 0.0188 mL 0.0938 mL 0.1875 mL 0.4688 mL
100 mM 0.0150 mL 0.0750 mL 0.1500 mL 0.3750 mL
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Zifanocycline TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZifanocyclineKBP-7072KBP7072KBP 7072BacterialInhibitorinhibitorinhibit

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