2. Anti-infection
  3. Bacterial Antibiotic
  4. Clinafloxacin

Clinafloxacin  (Synonyms: AM-1091; CI-960; PD 127391)

Cat. No.: HY-B0536 Purity: 98.34%
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Clinafloxacin (AM 1091) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro. Clinafloxacin is against DNA gyrase and topoisomerase IV of?S. aureus with IC50 values of 0.92 μg/ml and 1.62 μg/ml, respectively.

For research use only. We do not sell to patients.

Clinafloxacin Chemical Structure

Clinafloxacin Chemical Structure

CAS No. : 105956-97-6

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Based on 1 publication(s) in Google Scholar

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Clinafloxacin Related Antibodies

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Description

Clinafloxacin (AM 1091) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro[1]. Clinafloxacin is against DNA gyrase and topoisomerase IV of?S. aureus with IC50 values of 0.92 μg/ml and 1.62 μg/ml, respectively[2].

IC50 & Target

Quinolone

 

In Vitro

Clinafloxacin exhibits activity against S. pneumonia with an MIC of 1μg/ml for the parC-gyrA mutants[2].
Clinafloxacin hydrochloride has antibacterial activities against target-altered mutant strains of?S. aureus. It against Wild type S. aureus, gyrA?mutant S. aureus and gyrA?mutant S. aureus with MIC values of 0.016 μg/ml, 0.063 μg/ml and 0.915 μg/ml, respectively[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinafloxacin Related Antibodies
In Vivo

Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model.
With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

365.79

Formula

C17H17ClFN3O3
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CC(N)CC4)=C3Cl)C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (273.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7338 mL 13.6690 mL 27.3381 mL
5 mM 0.5468 mL 2.7338 mL 5.4676 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.34%

SDS (393 KB)

COA (248 KB) HNMR (209 KB) RP-HPLC (204 KB) LCMS (107 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7338 mL 13.6690 mL 27.3381 mL 68.3452 mL
5 mM 0.5468 mL 2.7338 mL 5.4676 mL 13.6690 mL
10 mM 0.2734 mL 1.3669 mL 2.7338 mL 6.8345 mL
15 mM 0.1823 mL 0.9113 mL 1.8225 mL 4.5563 mL
20 mM 0.1367 mL 0.6835 mL 1.3669 mL 3.4173 mL
25 mM 0.1094 mL 0.5468 mL 1.0935 mL 2.7338 mL
30 mM 0.0911 mL 0.4556 mL 0.9113 mL 2.2782 mL
40 mM 0.0683 mL 0.3417 mL 0.6835 mL 1.7086 mL
50 mM 0.0547 mL 0.2734 mL 0.5468 mL 1.3669 mL
60 mM 0.0456 mL 0.2278 mL 0.4556 mL 1.1391 mL
80 mM 0.0342 mL 0.1709 mL 0.3417 mL 0.8543 mL
100 mM 0.0273 mL 0.1367 mL 0.2734 mL 0.6835 mL
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Clinafloxacin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clinafloxacin105956-97-6AM-1091 CI-960 PD 127391AM1091AM 1091CI960CI 960CI-960PD127391PD 127391PD-127391BacterialAntibioticanaerobic pathogenantibioticbacteriaS. aureuspneumococcal meningitisInhibitorinhibitorinhibit

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