Antibacterial agent 220 

Antibacterial agent 220 is a potent antibacterial agent that can directly destroy bacterial cell membranes. Antibacterial agent 220 effectively combats Gram-positive and and Gram-negative pathogens, including drug-resistant strains^[1].

Antibacterial agent 220 (compound 43), which has a longer hydrophobic chain, exhibited potent antibacterial activity against both Gram-positive bacteria (MICs of 0.78-1.56 μg/mL) and Gram-negative bacteria (MIC of 6.25 μg/mL) and poor hemolytic activity (HC50 > 200 μg/mL). Antibacterial agent 220 shows MIC values of 1.56 μg/mL, 0.78 μg/mL, 0.78 μg/mL, and 6.25 μg/mL for S. aureus ATCC29213, MRSA N315, MRSA NCTC10442, and E. coli ATCC25922, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 220 (compound 43; 0.5%; applied topically to the infected murine corneas) exhibits a strong in vivo antibacterial efficacy in a murine corneal infection model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

770.94

C₃₇H₅₄N₈O₈S

O=S(C1=CC=C(OC/C=C(CC/C=C(C)/C)/C)C=C1)(C2=CC=C(OCC(N[C@@H](CCCNC(N)=N)C(N[C@H](C(OC)=O)CCCNC(N)=N)=O)=O)C=C2)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rongcui Zhong, et al. Development of novel bisphenol derivatives with a membrane-targeting mechanism as potent gram-positive antibacterial agents. Eur J Med Chem. 2024 May 31:274:116544.  [Content Brief]