H2A

By Targets:	Apoptosis (1) Bacterial (2) E1/E2/E3 Enzyme (6) p62 (1) PROTACs (1)
By Research Areas:	Cancer (6) Infection (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18643

TZ9 2 Publications Verification	E1/E2/E3 Enzyme Apoptosis	Cancer
TZ9 is a selective Rad6 inhibitor. TZ9 inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2-M arrest and apoptosis, and inhibits the proliferation and migration of metastatic human breast cancer cells .

HY-19817

PRT4165 5+ Cited Publications NSC600157	E1/E2/E3 Enzyme	Cancer
PRT4165 is a potent inhibitor of polycomb-repressive complex 1 (PRC1)-mediated H2A ubiquitylation.

HY-P0324A

Parasin I TFA	Bacterial	Infection
Parasin I (TFA) is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity .

HY-151799

Antitumor agent-81	p62 E1/E2/E3 Enzyme	Cancer
Antitumor agent-81 (compound 5a) is a low cytotoxicity P62-RNF168 agonist that enhances the interaction between P62 and RNF168. Antitumor agent-81 induces a reduction in *H2A* ubiquitination mediated by RNF168 and impairs homologous recombination-mediated DNA repair. Antitumor agent-81 also inhibits the growth of xenograft tumors in mice in a dose-dependent manner .

HY-139514

RB-3	E1/E2/E3 Enzyme	Cancer
RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a K_d of 2.8 μM .

HY-163518

Antitumor agent-153	E1/E2/E3 Enzyme	Cancer
Antitumor agent-153 (compound 11b) is an optimized *H2A* histone ubiquitination inhibitor based on PRT4165 (HY-19817). Antitumor agent-153 inhibits the viability of human osteosarcoma U2OS cells and reduces histone H2A monoubiquitination, exhibiting anticancer activity .

HY-P0324

Parasin I	Bacterial	Infection
Parasin I is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.

HY-160924

MS147	PROTACs E1/E2/E3 Enzyme	Cancer
MS147 is a VHL-based PROTAC degrader of PRC1 (Polycomb Repressive Complex 1). The dissociation constants (Kd) of MS147 for EED (Embryonic Ectoderm Development) and VHL (Von Hippel-Lindau) are 3.0 μM and 450 nM, respectively. MS147 specifically binds to the EED protein through its EED-binding moiety; EED is a core component of *PRC2* (Polycomb Repressive Complex 2) and interacts with the core components of PRC1, BMI1 (B-lymphoma Mo-MLV insertion region 1 homolog) and RING1B (Ring Finger Protein 1B). By this binding, MS147 is able to recruit BMI1 and RING1B near to VHL. Through the degradation of BMI1 and RING1B, MS147 reduces the level of H2AK119ub (histone H2A lysine 119 ubiquitination), affecting the proliferation of cancer cells. (Blue: VHL ligand (HY-125845), Black: linker ; Pink: PRC1 ligand (HY-158771)) .

Cat. No.	Product Name	Target	Research Area

HY-P2509

Histone H2A (1-20)	Peptides	Others
Histone H2A (1-20), a 35-residue a peptide of histone H2A, is a substrate for methyltransferase/demethylase enzymes .

HY-P0324A

Parasin I TFA	Bacterial	Infection
Parasin I (TFA) is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity .

HY-P0324

Parasin I	Bacterial	Infection
Parasin I is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P0324A

Parasin I TFA	Infection Structural Classification Natural Products Classification of Application Fields Animals Source classification Disease Research Fields	Bacterial
Parasin I (TFA) is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity .

HY-P0324

Parasin I	Infection Natural Products Classification of Application Fields Animals Source classification Disease Research Fields	Bacterial
Parasin I is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.

Species:	Human (2) Virus (1) Xenopus laevis (1)
Tag:	His (1) Tag Free (3)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P76382

	HIST3H2A Protein, Human Histone H2A type 3; H2AW; HIST3H2A	Human	E. coli
	The HIST3H2A protein is a core component of nucleosomes that compact DNA into chromatin. HIST3H2A Protein, Human is the recombinant human-derived HIST3H2A protein, expressed by E. coli , with tag free. The total length of HIST3H2A Protein, Human is 129 a.a., with molecular weight of 15-20 KDa.

HY-P72328

	H2AC4 Protein, Human " Histone H2A type 1-B/E; Histone H2A.2; Histone H2A/a; Histone H2A/m; H2AFM"	Human	E. coli
	The H2AC4 protein is a core component of nucleosomes, which compress DNA into chromatin and restrict DNA entry into cellular processes. H2AC4 Protein, Human is the recombinant human-derived H2AC4 protein, expressed by E. coli , with tag free. The total length of H2AC4 Protein, Human is 129 a.a., with molecular weight of ~14.0 kDa.

HY-P72330

	Histone H2A Protein, Xenopus laevis H2Ac14.L	Xenopus laevis	E. coli
	Histone H2A, an integral nucleosome component, forms the histone octamer with H2B, H3, and H4. This molecular spool, consisting of two H2A-H2B heterodimers and one H3-H4 heterotetramer, wraps around approximately 147 base pairs of DNA, organizing chromatin structure. The intricate histone-DNA association, especially with H2A, plays a vital role in regulating cellular processes like gene expression and DNA packaging. Histone H2A Protein, Xenopus laevis is the recombinant Xenopus laevis-derived Histone H2A protein, expressed by E. coli , with tag free. The total length of Histone H2A Protein, Xenopus laevis is 181 a.a., with molecular weight of ~12.3 kDa.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80941

	Phospho-Histone H2A.X (Ser139) Antibody 1 Publications Verification H2A.X; H2AFX; H2A/x; HIST5-2AX; Histone H2A.X; gamma H2A.X	WB, ICC/IF	Human, Mouse
	Phospho-Histone H2A.X (Ser139) Antibody is a non-conjugated and Mouse origined monoclonal antibody about 15 kDa, targeting to Histone H2AX. It can be used for WB,ICC/IF assays with N-6*His-tag, in the background of Human, Mouse.

HY-P80821

	Phospho-Histone H2A.X (Ser139) Antibody (YA191) H2A.X; H2AFX; H2A/x; HIST5-2AX; Histone H2A.X; gamma H2A.X	WB, IP	Human, Mouse, Rat
	Phospho-Histone H2A.X (Ser139) Antibody (YA191) is a non-conjugated and Rabbit origined monoclonal antibody about 15 kDa, targeting to Phospho-Histone H2A.X (Ser139). It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80161

	Histone H2A.X Antibody	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
	Histone H2A.X Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 15 kDa, targeting to Histone H2A.X. It can be used for WB,IF,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80159

	Histone H2A(acetyl K9) Antibody	WB, ICC/IF, IHC-P, ChIP	Human, Mouse
	Histone H2A(acetyl K9) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 14 kDa, targeting to Histone H2A(acetyl K9). It can be used for WB,ICC/IF,IHC-P,ChIP,CUT&Tag-seq assays with tag free, in the background of Human, Mouse.

HY-P80160

	Histone H2A (hydroxyl Y39) Antibody	WB, IHC-P	Human, Mouse
	Histone H2A (hydroxyl Y39) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 14 kDa, targeting to Histone H2A(hydroxyl Y39). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P83263

	Histone H2A Antibody (YA3008) Histone H2A.2	WB	Human, Rat
	Histone H2A Antibody (YA3008) is a biotin-conjugated non-conjugated IgG antibody, targeting Histone H2A, with a predicted molecular weight of 14 kDa (observed band size: 14 kDa). Histone H2A Antibody (YA3008) can be used for WB experiment in human, rat background.

HY-P83299

	Acetyl-Histone H2A Antibody (YA3044) H2AK9ac; H2A; H2A1B; H2AFM; HIST1H2A; Histone H2A.2; Histone H2A/a	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Acetyl-Histone H2A Antibody (YA3044) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3044), targeting Acetyl-Histone H2A, with a predicted molecular weight of 14 kDa (observed band size: 14 kDa). Acetyl-Histone H2A Antibody (YA3044) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P83587

	Hydroxyl-Histone H2A Antibody (YA3332) H2A.1; H2A/c; H2A1; H2AFC:; H2AFD; H2AFI; H2AFN; H2AFP; HIST1H2AG; HIST1H2AI; HIST1H2AK; HIST1H2AL; HIST1H2AM; histone cluster 1; H2Ai; Histone H2A type 1; Histone H2A/p	WB, IHC-P	Human, Mouse
	Hydroxyl-Histone H2A Antibody (YA3332) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3332), targeting Hydroxyl-Histone H2A, with a predicted molecular weight of 14 kDa (observed band size: 14 kDa). Hydroxyl-Histone H2A Antibody (YA3332) can be used for WB, IHC-P experiment in human, mouse background.

HY-P80162

	Histone H2A.Z Antibody	WB, IHC-P, ICC/IF	Human, Mouse
	Histone H2A.Z Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 14 kDa, targeting to Histone H2A.Z. It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse.

HY-P83441

	Macro H2A.1 Antibody (YA3186) H2A.y; H2A/y; mH2A1; H2AF12M; MACROH2A1.1; macroH2A1.2	WB, ICC/IF	Mouse, Rat
	Macro H2A.1 Antibody (YA3186) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3186), targeting Macro H2A.1, with a predicted molecular weight of 40 kDa (observed band size: 40 kDa). Macro H2A.1 Antibody (YA3186) can be used for WB, ICC/IF experiment in mouse, rat background.

HY-P80463

	Phospho-Histone H2A.X (Ser139) Antibody (YA190)	WB, IHC-P	Human, Mouse, Rat
	Phospho-Histone H2A.X (Ser139) Antibody (YA190) is a non-conjugated and Rabbit origined monoclonal antibody about 15 kDa, targeting to Phospho-Histone H2A.X(S139). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

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H2A

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