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JB-300

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-172144
    JB300

    		PROTACs Aurora Kinase Cancer
    JB300 is a highly selective Aurora A degrader based on PROTAC technology (DC50=30 nM). JB300 can be used for tumor research. JB300 consists of PROTAC target protein ligand MK-5108 (HY-13252) (pink part), E3 ligase ligand Thalidomide-O-COOH (HY-103597) (blue part) and PROTAC Linker Boc-NH-PEG2-C2-NH2 (HY-W008474) (black part), of which the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc (HY-172145) .
    JB300
  • HY-172145
    Thalidomide-O-CH2-CO-NH-C2-PEG2-NH-Boc

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc is a conjugate of E3 ligase ligand and linker, which contains Thalidomide-based CEREBLON ligand and PEG inker. Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc can be used to synthesize PROTAC degrader JB300 (HY-137341) .
    Thalidomide-O-CH2-CO-NH-C2-PEG2-NH-Boc

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