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Results for "

PH 11

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0869
    CAPS

    N-Cyclohexyl-3-aminopropanesulfonic acid

    		 Biochemical Assay Reagents Others
    CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis .
    CAPS
  • HY-116497
    PH11

    		Others Cancer
    PH11 is a novel focal adhesion kinase (FAK) inhibitor that rapidly induces apoptosis in TRAIL-resistant PANC-1 cells when combined with TRAIL, but has no effect on normal human fibroblasts. The study found that PH11 downregulates c-FLIP through inhibition of FAK and phosphatidylinositol-3-kinase (PI3K)/AKT pathways, thereby restoring the TRAIL apoptotic pathway, suggesting that this combination therapy may provide an attractive therapeutic strategy for the safe and effective treatment of pancreatic cancer. PH11 selectively inhibits c-FLIP expression by modulating upstream signaling pathways and may represent an innovative therapeutic strategy. Although further work is needed to fully elucidate the mechanism of PH11-induced TRAIL sensitization, we believe that our results will provide a new approach to target c-FLIP without the risk of interfering with caspase-8 processing, which could potentially lead to TRAIL resistance. This study also suggests a role for the FAK/AKT signaling pathway in regulating c-FLIP expression in TRAIL-induced apoptosis, and this understanding will provide important clues to control the resistance mechanism to optimize the potential of TRAIL-based pancreatic cancer treatment.
    PH11
  • HY-W102681
    3-(cyclohexylamino)-1-Propanesulfonic acid sodium salt

    		Biochemical Assay Reagents Others
    Caps sodium salt, a polyanion, is a surfactant. Caps sodium salt can be used as biological buffer (0.05 M, pH 11) for dialysis .
    3-(cyclohexylamino)-1-Propanesulfonic acid sodium salt
  • HY-D0869S
    3-(Cyclohexylamino)-1-propanesulfonic Acid-d17

    		Isotope-Labeled Compounds Others
    3-(Cyclohexylamino)-1-propanesulfonic Acid-d17 is the deuterium labeled CAPS[1]. CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis[2][3].
    3-(Cyclohexylamino)-1-propanesulfonic Acid-d17

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