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Results for "

Prenylated

" in MedChemExpress (MCE) Product Catalog:

46

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Peptides

37

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-122966
    Desmethylxanthohumol
    1 Publications Verification

    		 Apoptosis Cancer
    Desmethylxanthohumol is a prenylated hydroxychalcone isolated from hop cones (Humulus lupulus L.). Desmethylxanthohumol is a powerful apoptosis inducing agent. Desmethylxanthohumol has antiplasmodial, antiproliferative, and antioxidant bioactivities .
    Desmethylxanthohumol
  • HY-N6084
    Humulone

    α-Lupulic acid

    		 COX GABA Receptor Apoptosis Cardiovascular Disease
    Humulone (α-Lupulic acid), a prenylated phloroglucinol derivative, is a potent cyclooxygenase-2 (COX-2) inhibitor. Humulone acts as a positive modulator of GABAA receptor at low micromolar concentrations. Humulone is an inhibitor of bone resorption. Humulone possesses antioxidant, anti-angiogenic and apoptosis-inducing properties .
    Humulone
  • HY-N3776
    Dorsmanin A

    		Others Others
    Dorsmanin A is a prenylated flavonoid from the twigs of Dorstenia mannii .
    Dorsmanin A
  • HY-N3180
    Norbraylin

    		Phosphodiesterase (PDE) Inflammation/Immunology
    Norbraylin, a natural prenylated coumarin, is a PDE4D2 inhibitor with an IC50 value of 7.15 μM .
    Norbraylin
  • HY-N3853
    Erysubin A

    		Others Others
    Erysubin A is a prenylated isoflavonoid that can be isolated from Erinacea anthyllis .
    Erysubin A
  • HY-N3257
    Millewanin G

    		Estrogen Receptor/ERR Endocrinology
    Millewanin G is a prenylated isoflavonoid with antiestrogenic activity (IC50=29 μM). Millewanin G can be isolated from the leaves of M. pachycarpa cultivated in Japan .
    Millewanin G
  • HY-N8097
    Kushenol W

    		Bacterial Infection
    Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus .
    Kushenol W
  • HY-119552
    Acetylaszonalenin

    LL-S490β

    		 Endogenous Metabolite Neurokinin Receptor Neurological Disease
    Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [ 3H]-SP binding to human astrocytoma cells with a Ki of 170 μM .
    Acetylaszonalenin
  • HY-N10952
    Epicornuin F

    		Others Cancer
    Epicornuin F is a prenylated flavonoid. Epicornuin F can be isolated from the leaves of Epimedium brevicornu. Epicornuin F has the cytotoxic activity against HepG2 cells with an IC50 value of 33.4 μM. Epicornuin F can be used for the research of cancer .
    Epicornuin F
  • HY-N2693
    6,8-Diprenylorobol

    		Apoptosis Reactive Oxygen Species Caspase Akt ERK JNK p38 MAPK Bcl-2 Family Cancer
    6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS .
    6,8-Diprenylorobol
  • HY-N3920
    Gancaonin G

    		Bacterial Infection
    Gancaonin G is a 6-prenylated isoflavanone that can be isolated from Glycyrrhiza uralensis. Gancaonin G has antibacterial activity against Streptococcus mutants and MRSA strains .
    Gancaonin G
  • HY-N4316
    Flemiphilippinin A

    		Others Endocrinology
    Flemiphilippinin A is a prenylated isoflavone that can be isolated from Flemingia philippinensis .
    Flemiphilippinin A
  • HY-N11047
    7-O-methylepimedonin G

    		Others Others
    7-O-methylepimedonin G is a prenylated 2-phenoxychromone that can be isolated from Epimedium brevicornum .
    7-O-methylepimedonin G
  • HY-N8824
    Maackiaflavanone

    		Others Others
    Maackiaflavanone (compound 4) is a kind of prenylated flavanone. Maackia can be isolated from M. amurensi.
    Maackiaflavanone
  • HY-N3854
    Erysubin B

    		Others Others
    Erysubin B is a prenylated isoflavonoid, which can be isolated from the whole plant (roots and aerial parts) of Erinacea anthyllis .
    Erysubin B
  • HY-W749694
    Cannflavin B

    Canniflavone

    		 Others Inflammation/Immunology
    Cannflavin B is a prenylated flavone, which can be isolated from Cannabis sativa L. Cannflavin B has anti-inflammatory activity .
    Cannflavin B
  • HY-N8095
    Kushenol N

    		Others Cardiovascular Disease
    Kushenol N is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol N has anti-allergic and vasorelaxation activities .
    Kushenol N
  • HY-129605
    Ferulenol

    		Oxidative Phosphorylation Mitochondrial Metabolism Infection
    Ferulenol, a sesquiterpene prenylated coumarin derivative, specifically inhibits succinate ubiquinone reductase at the level of the ubiquinonecycle. Ferulenol shows good antimycobacterial activity and haemorrhagic action .
    Ferulenol
  • HY-N3737
    Derrone

    		Aurora Kinase PERK Reactive Oxygen Species Cancer
    Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity .
    Derrone
  • HY-N0622
    Morusin
    4 Publications Verification

    Mulberrochromene

    		 NF-κB STAT Bacterial Infection Inflammation/Immunology Cancer
    Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity.
    Morusin
  • HY-118563
    Farnesylthioacetic acid

    		Biochemical Assay Reagents Others
    S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine, which is a prenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase) competitive inhibitors. It also inhibits the methylation of farnesylated and geranylgeranylated substrates.
    Farnesylthioacetic acid
  • HY-N11841
    Mortatarin G

    		Glucosidase Metabolic Disease
    Mortatarin G (compound 3) is a prenylated flavonoid, that can be isolated from mulberry leaves. Mortatarin G exhibits good α-glucosidase inhibitory activity, with an IC50 of 20.4±1.4 μM .
    Mortatarin G
  • HY-N7196
    Myrtucommulone A

    		HSP Inflammation/Immunology
    Myrtucommulone A is a non-prenylated acylphloroglucinol that can be isolated from Myrtus communis (myrtle). Myrtucommulone A interacts with the HSP60 chaperone and inhibits HSP60 chaperone activity. Myrtucommulone A decreases the expression of LRP130, LONP .
    Myrtucommulone A
  • HY-133021
    Arazine

    N-Acetyl-S-farnesyl-L-cysteine

    		 Others Inflammation/Immunology
    Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site .
    Arazine
  • HY-121381
    Kuraridine

    		Phosphodiesterase (PDE) Others
    Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) (IC50=0.64 μM) .
    Kuraridine
  • HY-127029A
    Umbelliprenin

    		Lipoxygenase NO Synthase Neurological Disease Inflammation/Immunology Cancer
    Umbelliprenin, a prenylated coumarin, is an antioxidant with anticancer, anti-inflammatory and immunomodulatory effects. Umbelliprenin inhibits lipoxygenase managing the inflammation pathways. In inflammatory macrophages, Umbelliprenin suppresses nitric oxide production as well as inducible nitric oxide synthase (NO synthase) .
    Umbelliprenin
  • HY-P3350
    LS-BF1

    		Bacterial Infection
    LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].
    LS-BF1
  • HY-125612
    Artonin E

    5'-Hydroxymorusin

    		 Apoptosis Cancer
    Artonin E (5'-Hydroxymorusin) is a known prenylated flavonoid that induces apoptosis and arrests the cell cycle in S phase. Artonin E can induce anti-proliferative effects through mitochondrial pathway dysregulation and can be used in cancer research .
    Artonin E
  • HY-N3743
    Erythrivarone A

    Dihydroalpinumisoflavone

    		 Others Others
    Erythrivarone A is an isoflavone that can be isolated from the stem bark of Erythrina variegate .
    Erythrivarone A
  • HY-N0622R
    Morusin (Standard)

    		NF-κB STAT Bacterial Infection Inflammation/Immunology Cancer
    Morusin (Standard) is the analytical standard of Morusin. This product is intended for research and analytical applications. Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity.
    Morusin (Standard)
  • HY-N3426
    Kazinol B

    		NO Synthase Akt AMPK Metabolic Disease
    Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research .
    Kazinol B
  • HY-125538
    Deoxybrevianamide E

    		Endogenous Metabolite Inflammation/Immunology
    Deoxybrevianamide E, an indole alkaloid, is a biosynthetic precursor for advanced metabolites isolated from the marine-derived Aspergillus sp. .
    Deoxybrevianamide E
  • HY-N2554
    Osthenol

    Ostenol

    		 Monoamine Oxidase Neurological Disease
    Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B .
    Osthenol
  • HY-N8265
    Abyssinone V

    		HSV DNA/RNA Synthesis ATP Synthase Infection
    Abyssinone V is a prenylated flavonoid with predicted anti-viral activity. Abyssinone V can be isolated from the stem bark of Erythrina melanacantha. Abyssinone V possesses good pharmacodynamics properties. Abyssinone V is predicted to be antivirals including anti-herpes (HSV) agent, with mechanisms comprising inhibition of polymerase, ATPase and membrane integrity .
    Abyssinone V
  • HY-N6009
    8-Deoxygartanin

    		Parasite NF-κB Infection
    8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) . 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum . 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM .
    8-Deoxygartanin
  • HY-126109
    (±)-8-Prenylnaringenin

    		Estrogen Receptor/ERR Apoptosis Metabolic Disease Endocrinology Cancer
    (±)-8-Prenylnaringenin, a natural prenylated flavonoid, is a potent phytoestrogen. (±)-8-Prenylnaringenin is an orally active selective estrogen receptor modulator (SERM) (Estrogen Receptor/ERR) that inhibits ERα and ERβ with IC50s of 57 nM and 68 nM, respectively. (±)-8-Prenylnaringenin has anticancer effects, and can be used for osteoporosis research .
    (±)-8-Prenylnaringenin
  • HY-161144
    AKT-IN-21

    		Akt Apoptosis Cancer
    AKT-IN-21 (compound C36) is a potent AKT inhibitor with broad-spectrum cytotoxicity and anticancer activity. AKT-IN-21 also blocks the cell cycle and induces apoptosis of cancer cells by down-regulating the PI3K/AKT pathway .
    AKT-IN-21
  • HY-N2284
    Sophoflavescenol

    		Cholinesterase (ChE) Beta-secretase Phosphodiesterase (PDE) Cancer
    Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.
    Sophoflavescenol
  • HY-157116
    ICMT-IN-48

    		ICMT Cancer
    ICMT-IN-48 (compound 1) is an ICMT inhibitor that is competitive (Km=13 μM) for the prenylated methyl acceptor, the first substrate of ICMT. ICMT-IN-48 inhibits ICMT activity with IC50s affected by the concentration of the second substrate S-adenosylmethinine (SAM), and the IC50s are 3.5 μM (1×Km SAM) and 2.3 μM (10×Km SAM), respectively .
    ICMT-IN-48
  • HY-N3716
    Dehydroglyasperin D

    		Aldose Reductase COX Metabolic Disease Inflammation/Immunology
    Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi .
    Dehydroglyasperin D
  • HY-N8477
    Isolupalbigenin

    		NO Synthase Inflammation/Immunology
    Isolupalbigenin is an inhibitor of NO. Isolupalbigenin has anti-proliferative activity on HL-60 cells with an IC50 of 5.1 μM .
    Isolupalbigenin
  • HY-N2683
    5-O-Methylnaringenin

    		Others Others
    5-O-Methylnaringenin is a flavonoid compound. 5-O-Methylnaringenin is isolated from chloroacetic acid .
    5-O-Methylnaringenin
  • HY-N10009
    Cudraflavone B

    		NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin Inflammation/Immunology
    Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells .
    Cudraflavone B
  • HY-N1791
    3,5-Diprenyl-4-hydroxybenzaldehyde

    		Others Infection
    3, 5-diprenyl-4-hydroxybenzaldehyde is an isoprene phenyl butyl aldehyde. 3, 5-diprenyl-4-hydroxybenzaldehyde had the ability to inhibit biofilm formation in strains. 3, 5-diprenyl-4-hydroxybenzaldehyde can be used to study the potential synergistic effect of clinically relevant antibiotics .
    3,5-Diprenyl-4-hydroxybenzaldehyde
  • HY-145736A
    β-Glucuronide-dPBD-PEG5-NH2 TFA

    		Drug-Linker Conjugates for ADC Apoptosis Cancer
    β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity .
    β-Glucuronide-dPBD-PEG5-NH2 TFA
  • HY-145736
    β-Glucuronide-dPBD-PEG5-NH2

    		Drug-Linker Conjugates for ADC Apoptosis Cancer
    β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity .
    β-Glucuronide-dPBD-PEG5-NH2

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