2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Kuraridine

Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) (IC50=0.64 μM).

For research use only. We do not sell to patients.

Kuraridine Chemical Structure

Kuraridine Chemical Structure

CAS No. : 34981-25-4

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Based on 1 publication(s) in Google Scholar

Kuraridine Related Antibodies

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View All Phosphodiesterase (PDE) Isoform Specific Products:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • Biological Activity

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Description

Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) (IC50=0.64 μM)[1].

IC50 & Target[1]

PDE5

0.64 μM (IC50)

In Vitro

Kuraridine shows potent inhibitory activity (IC50=0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively[1].
Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal IGABA induced by a saturating GABA concentration (1 mM)[2].
Kuraridine induces a concentration–response curves for IGABA enhancement (EC50=4.0±2.4 μM) in Xenopus oocytes expressing GABAA receptors composed of α1, β2, and γ2S subunits[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kuraridine Related Antibodies
Molecular Weight

438.51

Formula

C26H30O6
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(C1=C(OC)C=C(O)C(C[C@H](C(C)=C)C/C=C(C)\C)=C1O)/C=C/C2=CC=C(O)C=C2O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (228.04 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2804 mL 11.4022 mL 22.8045 mL
5 mM 0.4561 mL 2.2804 mL 4.5609 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2804 mL 11.4022 mL 22.8045 mL 57.0112 mL
5 mM 0.4561 mL 2.2804 mL 4.5609 mL 11.4022 mL
10 mM 0.2280 mL 1.1402 mL 2.2804 mL 5.7011 mL
15 mM 0.1520 mL 0.7601 mL 1.5203 mL 3.8007 mL
20 mM 0.1140 mL 0.5701 mL 1.1402 mL 2.8506 mL
25 mM 0.0912 mL 0.4561 mL 0.9122 mL 2.2804 mL
30 mM 0.0760 mL 0.3801 mL 0.7601 mL 1.9004 mL
40 mM 0.0570 mL 0.2851 mL 0.5701 mL 1.4253 mL
50 mM 0.0456 mL 0.2280 mL 0.4561 mL 1.1402 mL
60 mM 0.0380 mL 0.1900 mL 0.3801 mL 0.9502 mL
80 mM 0.0285 mL 0.1425 mL 0.2851 mL 0.7126 mL
100 mM 0.0228 mL 0.1140 mL 0.2280 mL 0.5701 mL
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Kuraridine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kuraridine34981-25-4Phosphodiesterase (PDE)cGMPPDE5Sophora flavescensInhibitorinhibitorinhibit

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