2. NF-κB Apoptosis Immunology/Inflammation MAPK/ERK Pathway Stem Cell/Wnt Epigenetics Cell Cycle/DNA Damage
  3. NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin
  4. Cudraflavone B

Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells.

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Cudraflavone B Chemical Structure

Cudraflavone B Chemical Structure

CAS No. : 19275-49-1

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Cudraflavone B Related Antibodies

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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COX COX-1 COX-2 COX-3

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ERK ERK1 ERK2 ERK5 ERK8

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

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Description

Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells[1][2].

IC50 & Target[1][2]

NF-κB

 

COX-2

 

COX-1

 

TNFRSF1A

 

p38 MAP kinase

 

ERK

 

SIRT1

 

Cellular Effect
Cell Line Type Value Description References
THP-1 IC50
> 10 μM
Compound: 7
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
[PMID: 24901948]
Molecular Weight

420.45

Formula

C25H24O6
CAS No.
SMILES

O=C1C2=C(C3=C(C=C2OC(C4=C(O)C=C(O)C=C4)=C1C/C=C(C)\C)OC(C)(C)C=C3)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cudraflavone B Related Classifications

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Help & FAQs
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Keywords:

Cudraflavone B19275-49-1NF-κBTNF ReceptorCOXERKp38 MAPKSirtuinNuclear factor-κBNuclear factor-kappaBTumor Necrosis Factor ReceptorTNFRCyclooxygenaseExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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