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  3. Derrone

Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity.

For research use only. We do not sell to patients.

Derrone Chemical Structure

Derrone Chemical Structure

CAS No. : 76166-59-1

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Description

Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity[1][2].

IC50 & Target

IC50: 6 μM (Aurora kinase B), 22.3 μM (Aurora kinase A)[1]

Cellular Effect
Cell Line Type Value Description References
U-937 IC50
13 μM
Compound: 16, derrone
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
[PMID: 17158054]
U-937 IC50
20 μM
Compound: 16, derrone
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
[PMID: 17158054]
U-937 IC50
26 μM
Compound: 16, derrone
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
[PMID: 17158054]
In Vitro

Derrone (30-60 μM, 15 days) significantly inhibits the formation and growth of MCF7 tumor spheroids, with the tumor spheroid growth inhibition (% TGI) of 17.5% and 65.4% for 30 and 60?μM Derrone, respectively[1].
Derrone shows the autophagic features, such as the conversion of LC3-I to LC3-II, the formation of autophagosome and the downregulation of SQSTM1/p62 (p62)[2].
Derrone induces autophagic cell death through intracellular ROS and sustained ERK phosphorylation in A549 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

336.34

Formula

C20H16O5

CAS No.
SMILES

O=C1C2=C(O)C=C3C(C=CC(C)(C)O3)=C2OC=C1C4=CC=C(O)C=C4

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
Derrone
Cat. No.:
HY-N3737
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