2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. Myrtucommulone A

Myrtucommulone A is a non-prenylated acylphloroglucinol that can be isolated from Myrtus communis (myrtle). Myrtucommulone A interacts with the HSP60 chaperone and inhibits HSP60 chaperone activity. Myrtucommulone A decreases the expression of LRP130, LONP.

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Myrtucommulone A Chemical Structure

Myrtucommulone A Chemical Structure

CAS No. : 54247-21-1

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Myrtucommulone A Related Antibodies

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Description

Myrtucommulone A is a non-prenylated acylphloroglucinol that can be isolated from Myrtus communis (myrtle). Myrtucommulone A interacts with the HSP60 chaperone and inhibits HSP60 chaperone activity. Myrtucommulone A decreases the expression of LRP130, LONP[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
1 μM
Compound: 1, myrtucommulone A, MC A
Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 formation preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis
Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 formation preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis
[PMID: 26123643]
DU-145 IC50
5 μM
Compound: 4
Cytotoxicity against human DU145 cells after 96 hrs
Cytotoxicity against human DU145 cells after 96 hrs
[PMID: 22276775]
HepG2 IC50
6 μM
Compound: 4
Cytotoxicity against human HepG2 cells after 96 hrs
Cytotoxicity against human HepG2 cells after 96 hrs
[PMID: 22276775]
Jurkat EC50
2.4 μM
Compound: 1, myrtucommulone A, MC A
Cytotoxicity against human Jurkat cells assessed as induction of cell death after 48 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as induction of cell death after 48 hrs by MTT assay
[PMID: 26123643]
MT4 IC50
4.7 μM
Compound: 4
Cytotoxicity against human MT4 cells after 96 hrs
Cytotoxicity against human MT4 cells after 96 hrs
[PMID: 22276775]
In Vitro

Myrtucommulone A (0, 10, 30 µM) decreases the expression of leucine-rich PPR motif-containing protein (LRP130, Lon protease-like protein (LONP) at 37 ℃ and 42 ℃[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Myrtucommulone A Related Antibodies
Molecular Weight

668.81

Formula

C38H52O10
CAS No.
SMILES

CC(C)[C@@H](C(C(C(C)(C1=O)C)=O)=C(C1(C)C)O)C(C(O)=C2C(C(C)C)=O)=C(C([C@H](C(C(C(C)(C3=O)C)=O)=C(C3(C)C)O)C(C)C)=C2O)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Myrtucommulone A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Myrtucommulone A54247-21-1HSPHeat shock proteinsHSP60 chaperoneLRP130LONPInhibitorinhibitorinhibit

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