2. Anti-infection NF-κB
  3. Parasite NF-κB
  4. 8-Deoxygartanin

8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE). 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM.

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8-Deoxygartanin Chemical Structure

8-Deoxygartanin Chemical Structure

CAS No. : 33390-41-9

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Based on 1 publication(s) in Google Scholar

8-Deoxygartanin Related Antibodies

Top Publications Citing Use of Products

View All Parasite Isoform Specific Products:

View All Isoforms
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Biological Activity

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Description

8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE)[1]. 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum[2]. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM[3].

IC50 & Target

Plasmodium

 

p65

11.3 μM (IC50)

Molecular Weight

380.43

Formula

C23H24O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C/C(C)=C\CC1=C(O)C(C/C=C(C)/C)=C(O)C(C(C2=CC=C3)=O)=C1OC2=C3O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (262.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6286 mL 13.1430 mL 26.2860 mL
5 mM 0.5257 mL 2.6286 mL 5.2572 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.24%

SDS (251 KB)

COA (251 KB) HNMR (130 KB) RP-HPLC (144 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6286 mL 13.1430 mL 26.2860 mL 65.7151 mL
5 mM 0.5257 mL 2.6286 mL 5.2572 mL 13.1430 mL
10 mM 0.2629 mL 1.3143 mL 2.6286 mL 6.5715 mL
15 mM 0.1752 mL 0.8762 mL 1.7524 mL 4.3810 mL
20 mM 0.1314 mL 0.6572 mL 1.3143 mL 3.2858 mL
25 mM 0.1051 mL 0.5257 mL 1.0514 mL 2.6286 mL
30 mM 0.0876 mL 0.4381 mL 0.8762 mL 2.1905 mL
40 mM 0.0657 mL 0.3286 mL 0.6572 mL 1.6429 mL
50 mM 0.0526 mL 0.2629 mL 0.5257 mL 1.3143 mL
60 mM 0.0438 mL 0.2191 mL 0.4381 mL 1.0953 mL
80 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.8214 mL
100 mM 0.0263 mL 0.1314 mL 0.2629 mL 0.6572 mL
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8-Deoxygartanin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-Deoxygartanin33390-41-9ParasiteNF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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