2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway
  3. Apoptosis Reactive Oxygen Species Caspase Akt ERK JNK p38 MAPK Bcl-2 Family
  4. 6,8-Diprenylorobol

6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS.

For research use only. We do not sell to patients.

6,8-Diprenylorobol Chemical Structure

6,8-Diprenylorobol Chemical Structure

CAS No. : 66777-70-6

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Based on 1 publication(s) in Google Scholar

6,8-Diprenylorobol Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Akt Akt1 Akt2 Akt3

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ERK ERK1 ERK2 ERK5 ERK8

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JNK1 JNK2 JNK3 JNK

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Description

6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS[1][2].

Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
14.3 μM
Compound: 19
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
[PMID: 31403786]
In Vitro

6,8-Diprenylorobol (20-60 μM; 24-72 h) inhibits proliferation in LoVo and HCT15 cells[1].
6,8-Diprenylorobol (20-60 μM; 24 h) induces apoptosis and activates p53 and regulates MAPKs in LoVo and HCT15 cells[1].
6,8-Diprenylorobol (20-60 μM; 1 h) increases ROS level in LoVo and HCT15 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6,8-Diprenylorobol Related Antibodies

Cell Viability Assay[1]

Cell Line: LoVo and HCT15 cells
Concentration: 20, 40, and 60 μM
Incubation Time: 24, 48, and 72 hours
Result: Inhibited the growth of LoVo and HCT15 cells in a dose- and dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: LoVo and HCT15 cells
Concentration: 20, 40, and 60 μM
Incubation Time: 24 hours
Result: Induced apoptosis of LoVo and HCT15 cells in a dose- and time-dependent manner.

Western Blot Analysis[1]

Cell Line: LoVo and HCT15 cells
Concentration: 20, 40, and 60 μM
Incubation Time: 24, 48, and 72 hours
Result: Decreased the expression of PARP and increased the expression of cleaved PARP.
Up-regulated Bax and Bim expressions and downregulated Bcl-2 expression.
Up-regulated cleaved caspase-3, -7, -8, and -9 expressions, and down-regulated procaspase-3, -7, -8, and -9 expressions.
Decreased the expression of phosphorylated Akt, ERK, JNK, and p38 and increased the expression of FOXO3, p53, p27, and p21.
Molecular Weight

422.47

Formula

C25H26O6
CAS No.
SMILES

O=C1C(C2=CC=C(O)C(O)=C2)=COC3=C(C/C=C(C)\C)C(O)=C(C/C=C(C)\C)C(O)=C13
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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6,8-Diprenylorobol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6,8-Diprenylorobol66777-70-6ApoptosisReactive Oxygen SpeciesCaspaseAktERKJNKp38 MAPKBcl-2 FamilyPKBProtein kinase BExtracellular signal regulated kinasesc-Jun N-terminal kinaseprenylated isoflavoneCudrania tricuspidatanature productanyitumorLoVoHCT15Inhibitorinhibitorinhibit

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