Artonin E  (Synonyms: 5'-Hydroxymorusin)

Artonin E (5'-Hydroxymorusin) is a known prenylated flavonoid that induces apoptosis and arrests the cell cycle in S phase. Artonin E can induce anti-proliferative effects through mitochondrial pathway dysregulation and can be used in cancer research^[1].

Artonin E (0-100 μg/mL, 24-72 h) acts on SKOV-3 cells, T1074 cells, human periodontal ligament fibroblasts and CHO cells with the IC₅₀ values of 12.83, 44.8, 67 and 57.6 μg/mL, respectively . And it can reduce the cell viability of SKOV-3 cells in a time-dependent manner^[1].
Artonin E(0-20 μg/mL, 24 h) can inhibit the colony formation of SKOV-3 cells in a dose-dependent manner. At 5 μg/mL, almost half of the colonies were reduced. When using 15 and 20 μg/mL, No colonies formed^[1].
Artonin E (8 μg/mL, 24-72 h) can induce the depletion of SKOV-3 cells in S phase, and at 72 h, the accumulation of cells arrested in S phase was significantly increased, while the ratio of cells in G0/G1 phase decreased^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

436.45

C₂₅H₂₄O₇

129683-93-8

O=C1C2=C(O)C=C3C(C=CC(C)(C)O3)=C2OC(C4=CC(O)=C(O)C=C4O)=C1C/C=C(C)\C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mashitoh Abd Rahman, et al. Artonin E Induces Apoptosis via Mitochondrial Dysregulation in SKOV-3 Ovarian Cancer Cells. PLoS One. 2016 Mar 28;11(3):e0151466.   [Content Brief]