Umbelliprenin

Name: Umbelliprenin
Brand: MedChemExpress
SKU: HY-127029A
Rating: 4.5 (1 reviews)

Cat. No.: HY-127029A Purity: 99.93%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Umbelliprenin, a prenylated coumarin, is an antioxidant with anticancer, anti-inflammatory and immunomodulatory effects. Umbelliprenin inhibits lipoxygenase managing the inflammation pathways. In inflammatory macrophages, Umbelliprenin suppresses nitric oxide production as well as inducible nitric oxide synthase (NO synthase).

For research use only. We do not sell to patients.

Umbelliprenin Chemical Structure

CAS No. : 23838-17-7

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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nNOS iNOS eNOS

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5-LOX 12-LOX 15-LOX

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	71 μM Compound: 3	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 21696954]
BT-549	IC₅₀	1.1 pM Compound: 8	Antiproliferative activity against human BT549 cells after 24 hrs by MTT assay Antiproliferative activity against human BT549 cells after 24 hrs by MTT assay	[PMID: 29144746]
LoVo	IC₅₀	50 μM Compound: 3	Cytotoxicity against human LoVo cells after 72 hrs by MTT assay Cytotoxicity against human LoVo cells after 72 hrs by MTT assay	[PMID: 21696954]
MDA-MB-231	IC₅₀	30 μM Compound: 8	Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay	[PMID: 29144746]
PC-3	IC₅₀	75 μM Compound: 3	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 21696954]
SK-MEL-28	IC₅₀	66 μM Compound: 3	Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay	[PMID: 21696954]
U-373MG ATCC	IC₅₀	72 μM Compound: 3	Cytotoxicity against human U373 cells after 72 hrs by MTT assay Cytotoxicity against human U373 cells after 72 hrs by MTT assay	[PMID: 21696954]

In Vivo

Umbelliprenin (6.25-25 mg/kg; ip; once) alleviates neuropathic pain, and decreased serum IL-6 levels and oxidative stress^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male albino mice (30-35 g; 4 weeks old) injected with Paclitaxel (2 mg/kg)^[1]
Dosage:	6.25, 12.5 and 25 mg/kg
Administration:	ip; once
Result:	Effectively attenuated hyperalgesia, lipid peroxidation and IL-6 levels.

Molecular Weight

366.49

Formula

C₂₄H₃₀O₃

CAS No.

23838-17-7

Appearance

Solid

Color

White to off-white

SMILES

C/C(C)=C/CC/C(C)=C/CC/C(C)=C/COC1=CC=C(C=CC(O2)=O)C2=C1

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (272.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7286 mL	13.6429 mL	27.2859 mL
5 mM	0.5457 mL	2.7286 mL	5.4572 mL
10 mM	0.2729 mL	1.3643 mL	2.7286 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.93%

Select Batch:

Data Sheet (266 KB) SDS (252 KB)

COA (241 KB) HNMR (271 KB) RP-HPLC (244 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Jafar Shahraki, et al. Umbelliprenin relieves paclitaxel-induced neuropathy. J Pharm Pharmacol. 2020 Dec;72(12):1822-1829. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7286 mL	13.6429 mL	27.2859 mL	68.2147 mL
	5 mM	0.5457 mL	2.7286 mL	5.4572 mL	13.6429 mL
	10 mM	0.2729 mL	1.3643 mL	2.7286 mL	6.8215 mL
	15 mM	0.1819 mL	0.9095 mL	1.8191 mL	4.5476 mL
	20 mM	0.1364 mL	0.6821 mL	1.3643 mL	3.4107 mL
	25 mM	0.1091 mL	0.5457 mL	1.0914 mL	2.7286 mL
	30 mM	0.0910 mL	0.4548 mL	0.9095 mL	2.2738 mL
	40 mM	0.0682 mL	0.3411 mL	0.6821 mL	1.7054 mL
	50 mM	0.0546 mL	0.2729 mL	0.5457 mL	1.3643 mL
	60 mM	0.0455 mL	0.2274 mL	0.4548 mL	1.1369 mL
	80 mM	0.0341 mL	0.1705 mL	0.3411 mL	0.8527 mL
	100 mM	0.0273 mL	0.1364 mL	0.2729 mL	0.6821 mL

Umbelliprenin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Umbelliprenin23838-17-7NO SynthaseLipoxygenaseNitric oxide synthasesNOSLOXlipoxygenase InhibitorL-10IFN-γ and IL-4anticanceranti-inflammatory and immunomodulatory effectsInhibitorinhibitorinhibit

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Umbelliprenin

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Umbelliprenin Related Antibodies

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Complete Stock Solution Preparation Table

Umbelliprenin Related Classifications

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