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Results for "

carboline

" in MedChemExpress (MCE) Product Catalog:

47

Inhibitors & Agonists

23

Natural
Products

5

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N1633
    1-Methoxycarbonyl-β-carboline

    		Others Others
    1-Methoxycarbonyl-β-carboline is a natural alkaloid .
    1-Methoxycarbonyl-β-carboline
  • HY-W130965
    1-Formyl-beta-carboline

    		Influenza Virus Akt Infection
    1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway .
    1-Formyl-beta-carboline
  • HY-20696R
    Tetrahydro-β-carboline (Standard)

    		5-HT Receptor Metabolic Disease
    Tetrahydro-β-carboline (Standard) is the analytical standard of Tetrahydro-β-carboline. This product is intended for research and analytical applications. Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 μM .
    Tetrahydro-β-carboline (Standard)
  • HY-29268
    β-Carboline-1-carboxylic acid

    		Bacterial Indoleamine 2,3-Dioxygenase (IDO) NF-κB Phosphodiesterase (PDE) Infection Inflammation/Immunology Cancer
    β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC50: 96 µM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT). In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC50: 47.70 μg/mL) and E. coli (IC50: 19.17 μg/mL) .
    β-Carboline-1-carboxylic acid
  • HY-W197533
    3-Hydroxymethyl-β-carboline

    		Others Neurological Disease
    3-Hydroxymethyl-β-carboline antagonizes the anxiolytic and anticonvulsant actions of Diazepam and reverses the sedative action of Flurazepam. 3-Hydroxymethyl-β-carboline also antagonizes the cerebrovascular and cerebral metabolic depression produced by Flurazepam .
    3-Hydroxymethyl-β-carboline
  • HY-W049881
    9-Methyl-β-carboline

    		Dopamine Receptor Neurological Disease Inflammation/Immunology
    9-Methyl-β-carboline is a cognitive enhancer with neuroprotective, neurorestorative and anti-inflammatory properties. The behavioral effects of 9-Methyl-β-carboline may be related to the stimulation of hippocampal dopamine levels and dendritic and synaptic proliferation .
    9-Methyl-β-carboline
  • HY-150511
    3-(3-Phenoxybenzyl)amino-β-carboline

    		Microtubule/Tubulin Apoptosis Cancer
    3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity .
    3-(3-Phenoxybenzyl)amino-β-carboline
  • HY-N2926
    β-Carboline-1-propionic acid

    		Parasite Infection
    β-Carboline-1-propionic acid is a alkaloid which can be extracted from Ailanthus altissima. β-Carboline-1-propionic acid can be used as an antileishmanial agent .
    β-Carboline-1-propionic acid
  • HY-N1905
    4-Methoxy-β-carboline-1-carboxylic acid methylester

    		Others Others
    4-Methoxy-β-carboline-1-carboxylic acid methylester is an alkaloid with the structure of canthin-6-one and β-carboline .
    4-Methoxy-β-carboline-1-carboxylic acid methylester
  • HY-N11016
    1-Methoxymethyl-β-carboline

    		Others Others
    1-Methoxymethyl-β-carboline is a natural product isolated from the root of Eurycoma longifolia .
    1-Methoxymethyl-β-carboline
  • HY-N7173
    7-Methoxy-β-carboline-1-propionic acid

    		Parasite Infection
    7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .
    7-Methoxy-β-carboline-1-propionic acid
  • HY-20696
    Tetrahydro-β-carboline

    Tryptoline

    		 5-HT Receptor Metabolic Disease
    Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 µM .
    Tetrahydro-β-carboline
  • HY-N13343
    1-Methoxycarbonyl-beta-carboline-N-oxide

    		Others Others
    1-Methoxycarbonyl-beta-carboline-N-oxide is a natural product .
    1-Methoxycarbonyl-beta-carboline-N-oxide
  • HY-N9009
    1-Hydroxymethyl-β-carboline glucoside

    		Others Others
    1-Hydroxymethyl-β-carboline glucoside (Compound 13) is a natural product that can be isolated from Picrasma quassioides .
    1-Hydroxymethyl-β-carboline glucoside
  • HY-N9813
    1-(3,4,5-Trihydroxypentanoyl)-β-carboline

    		Others Others
    1-(3,4,5-Trihydroxypentanoyl)-β-carboline is a natural product .
    1-(3,4,5-Trihydroxypentanoyl)-β-carboline
  • HY-137494
    Ethyl β-carboline-3-carboxylate

    		GABA Receptor Neurological Disease
    Ethyl β-carboline-3-carboxylate (fl-CCE) is a ligand and short-acting antagonist of benzodiazepine receptors. Ethyl β-carboline-3-carboxylate did not affect cerebellar cGMP levels when used alone, but when taken together with Diazepam, it significantly inhibited the cGMP levels that were upregulated by Diazepam .
    Ethyl β-carboline-3-carboxylate
  • HY-W031110
    2-Methyl-tetrahydro-β-carboline

    2-MTHBC

    		 Drug Metabolite Neurological Disease
    2-Methyl-tetrahydro-β-carboline is a cyclization product of N,N-dimethyltryptamine after oral administration of ayahuasca .
    2-Methyl-tetrahydro-β-carboline
  • HY-N10450
    Kumujian A

    1-Ethoxycarbonyl-β-carboline

    		 Reactive Oxygen Species Inflammation/Immunology
    Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC50 = 4.87 μg/mL) and elastase release (IC50 = 6.29 μg/mL) .
    Kumujian A
  • HY-33169
    1,2,3,4-Tetrahydro-β-carboline-1-carboxylic acid

    		Others Neurological Disease
    1,2,3,4-Tetrahydro-β-carboline-1-carboxylic acid is a chemical used on the study of neurodegenerative diseases .
    1,2,3,4-Tetrahydro-β-carboline-1-carboxylic acid
  • HY-W060074
    1-Acetyl-β-carboline

    1-(9H-pyrido[3,4-b]indol-1-yl)ethanone

    		 Others Infection
    1-Acetyl-β-carboline is metabolite of Nonomuraea endophytica .
    1-Acetyl-β-carboline
  • HY-W008566
    Norharmane

    Norharman; β-carboline

    		 Monoamine Oxidase Endogenous Metabolite Infection Neurological Disease Cancer
    Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .
    Norharmane
  • HY-123139
    Flutroline

    CP-36584

    		 Others Neurological Disease
    Flutroline (CP-36584), a tetrahydro-7-carboline compound, is an orally active and potent anti-psychotic compound .
    Flutroline
  • HY-107811A
    Harmol hydrochloride

    		Monoamine Oxidase Others
    Harmol hydrochloride categorized as a β-carboline alkaloid. Harmol hydrochloride is a potent MAO inhibitor .
    Harmol hydrochloride
  • HY-W700491
    AalphaC-15N3

    2-Amino-α-carboline-15N3; AαC-15N3

    		 Isotope-Labeled Compounds Endogenous Metabolite Cancer
    AalphaC- 15N3 (2-Amino-α-carboline- 15N3) is 15N labeled AalphaC. AalphaC (AαC) is a potential carcinogen with carcinogenic activity. AalphaC is an important biomarker in tobacco smoke and is associated with tobacco smoke exposure. Urinary concentrations of AalphaC are significantly higher in dedicated smokers than in non-smokers, indicating its importance in monitoring tobacco exposure. AalphaC levels increase significantly with increasing serum nicotine levels, indicating its close relationship with tobacco use. In addition, consuming high-temperature cooked beef significantly increases the amount of AalphaC in urine, while consuming vegetables is associated with a decrease in AalphaC concentrations. Smoking half a pack of cigarettes is associated with a significant increase in the amount of AalphaC, which further confirms the biological activity of AalphaC and its association with dietary habits .
    AalphaC-15N3
  • HY-106484
    Tiflucarbine

    BAY-P 4495

    		 5-HT Receptor Neurological Disease
    Tiflucarbine (BAY-P 4495) is a tetrahydrothieno-7-carboline derivative. Tiflucarbine is a potent antidepressant agent that binds at central serotonin (5-HT) binding sites. Tiflucarbine is a nonselective 5-HT (5-HT1 and 5-HT2) agonist .
    Tiflucarbine
  • HY-N10960
    Stellarine C

    		Others Others
    Stellarine C is a β-carboline alkaloid that can be isolated from Stellaria dichotoma var. lanceolata .
    Stellarine C
  • HY-114652
    AalphaC

    2-Amino-α-carboline; AαC

    		 Endogenous Metabolite Cancer
    AalphaC (AαC) is a potential carcinogen with carcinogenic activity. AalphaC is an important biomarker in tobacco smoke and is associated with tobacco smoke exposure. Urinary concentrations of AalphaC are significantly higher in dedicated smokers than in non-smokers, indicating its importance in monitoring tobacco exposure. AalphaC levels increase significantly with increasing serum nicotine levels, indicating its close relationship with tobacco use. In addition, consuming high-temperature cooked beef significantly increases the amount of AalphaC in urine, while consuming vegetables is associated with a decrease in AalphaC concentrations. Smoking half a pack of cigarettes is associated with a significant increase in the amount of AalphaC, which further confirms the biological activity of AalphaC and its association with dietary habits .
    AalphaC
  • HY-N10386
    Dichotomine B

    		Others Inflammation/Immunology
    Dichotomine B, a β-Carboline alkaloid, attenuates neuroinflammatory responses in LPS/ATP-induced BV2 microglia .
    Dichotomine B
  • HY-N10955
    Dichotomine H

    		Others Inflammation/Immunology
    Dichotomine H is a P-carboline alkaloid that can be extracted from Stellaria dichotoma L. Dichotomine H has good antiallergic activity .
    Dichotomine H
  • HY-150516S
    BET-IN-12

    		Epigenetic Reader Domain Cancer
    BET-IN-12 is an orally avtive inhibitor of bromodomain and extra-terminal (BET) with an IC50 of 0.9 nM for BRD4[1].
    BET-IN-12
  • HY-107811R
    Harmol (Standard)

    		Monoamine Oxidase Neurological Disease
    Harmol (Standard) is the analytical standard of Harmol. This product is intended for research and analytical applications. Harmol categorized as a β-carboline alkaloid. Harmol is a potent MAO inhibitor used as an analytical reference standard .
    Harmol (Standard)
  • HY-N3711
    Dehydrocrenatine

    		JNK ERK Apoptosis Neurological Disease
    Dehydrocrenatidine, a β-carboline alkaloid that can be isolated from Picrasma quassioides. Dehydrocrenatidine induces cell apoptosis by activates ERK and JNK. Dehydrocrenatidine inhibits invasion and migration of cancer cells, it also suppresses neuronal excitability to exert analgesic effects .
    Dehydrocrenatine
  • HY-N2625A
    Harmalol hydrochloride

    		Cytochrome P450 Cancer
    Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties .
    Harmalol hydrochloride
  • HY-100924
    β-CCB

    		GABA Receptor Neurological Disease
    β-CCB is a ligand for benzodiazepine receptor, which inhibits the binding of [ 3H]flunitrazepam and ethyl (3-[ 3H]carboline-3-carboxylate to benzodiazepine receptors, with Ki of 3-4 nM. β-CCB exhibits proconvulsant and anxiogenic effects .
    β-CCB
  • HY-154993
    Gamma-Glutamyl Transferase-IN-1

    		Fungal Infection
    Gamma-Glutamyl Transferase-IN-1 (compound 4de) is a β-carboline 1-hydrazide inhibitor with antifungal and antibacterial activities, targeting to glutamyltransferase. Gamma-Glutamyl Transferase-IN-1 acts function by resulting the accumulation of reactive oxygen species, destruction of cell membranes, and dysregulation of histone acetylation .
    Gamma-Glutamyl Transferase-IN-1
  • HY-154996
    Gamma-Glutamyl Transferase-IN-2

    		Fungal Infection
    Gamma-Glutamyl Transferase-IN-2 (compound 4dq) is a β-carboline 1-hydrazide inhibitor with antifungal and antibacterial activities, targeting to glutamyltransferase. Gamma-Glutamyl Transferase-IN-2 acts function by resulting the accumulation of reactive oxygen species, destruction of cell membranes, and dysregulation of histone acetylation .
    Gamma-Glutamyl Transferase-IN-2
  • HY-N2625AR
    Harmalol (hydrochloride) (Standard)

    		Cytochrome P450 Others
    Harmalol (hydrochloride) (Standard) is the analytical standard of Harmalol (hydrochloride). This product is intended for research and analytical applications. Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties .
    Harmalol (hydrochloride) (Standard)
  • HY-115909
    ZDLD20

    		CDK Cancer
    ZDLD20, a β-carboline, is orally active and selective CDK4/CycD3 inhibitor with an IC50 value of 6.51  μM. ZDLD20 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD20 exhibits potent anticancer activity .
    ZDLD20
  • HY-117025A
    Manzamine A hydrochloride
    1 Publications Verification

    Keramamine A hydrochloride

    		 GSK-3 CDK Parasite Proton Pump HSV Autophagy Infection Neurological Disease Cancer
    Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1 .
    Manzamine A hydrochloride
  • HY-117025
    Manzamine A

    Keramamine A

    		 GSK-3 CDK Parasite Proton Pump HSV Autophagy Infection Neurological Disease Cancer
    Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1 .
    Manzamine A
  • HY-115908
    ZDLD13

    		CDK Apoptosis Cancer
    ZDLD13, a β-carboline, is an orally active and selective CDK4/CycD3 inhibitor with an IC50 value of 0.38 μM. ZDLD13 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD13 shows significant tumor growth inhibition in HCT116 tumor xenograft model .
    ZDLD13
  • HY-170594
    Antitumor agent-192

    		Atg7 Autophagy Cancer
    Antitumor agent-192 (Compound 2f) is a β-carboline antitumor agent. Antitumor agent-192 induces autophagy in HCT116 cells via the ATG5/ATG7 pathway. Antitumor agent-192 has an IC50 of less than 5 μM for human tumor cell lines and significantly inhibits tumor development and reduces tumor weight in a mouse colorectal cancer model transplanted with allografts [1].
    Antitumor agent-192
  • HY-W700241
    Norharman-d7

    		Isotope-Labeled Compounds Monoamine Oxidase Endogenous Metabolite Infection Neurological Disease Cancer
    Norharman-d7 is deuterium labeled Norharmane. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .
    Norharman-d7
  • HY-W008566R
    Norharmane (Standard)

    		Monoamine Oxidase Endogenous Metabolite Infection Neurological Disease Cancer
    Norharmane (Standard) is the analytical standard of Norharmane. This product is intended for research and analytical applications. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .
    Norharmane (Standard)
  • HY-101392S
    Harmane-d1

    		Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor Neurological Disease Cancer
    Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].
    Harmane-d1
  • HY-101392S1
    Harmane-d2

    		Isotope-Labeled Compounds Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor Neurological Disease Cancer
    Harmane-d2 is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].
    Harmane-d2
  • HY-101392R
    Harmane (Standard)

    		Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor Neurological Disease Cancer
    Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect .
    Harmane (Standard)

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