1-Formyl-beta-carboline

Cat. No.: HY-W130965 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway.

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1-Formyl-beta-carboline Chemical Structure

CAS No. : 20127-63-3

Size	Price	Stock	Quantity
1 mg	USD 114	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 269	Get quote	Estimated Time of Arrival: December 31
10 mg	USD 395	Get quote	Estimated Time of Arrival: December 31
25 mg	USD 595	Get quote	Estimated Time of Arrival: December 31
50 mg	USD 835	Get quote	Estimated Time of Arrival: December 31
100 mg	USD 1170	Get quote	Estimated Time of Arrival: December 31
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Description	1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway^[1].
Molecular Weight	196.20
Formula	C₁₂H₈N₂O
CAS No.	20127-63-3
Appearance	Solid
SMILES	C1=CC=C2C(=C1)C3=C(C(=NC=C3)C=O)N2
Structure Classification	Alkaloids Pyridine Alkaloids
Initial Source	Plants Simaroubaceae Picrasma quassioides(D．Don)Benn．
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation	Purity: 99.70% Select Batch: Data Sheet (271 KB) SDS (393 KB) COA (254 KB) HNMR (132 KB) RP-HPLC (231 KB) Handling Instructions (2659 KB)
References	[1]. 1-Formyl- β-carboline Derivatives Block Newcastle Disease Virus Proliferation through Suppressing Viral Adsorption and Entry Processes [Content Brief]