Search Result

Results for "

estrogen activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Estrogen Receptor/ERR (62) Androgen Receptor (1) Apoptosis (14) Autophagy (7) Bacterial (7) Calcium Channel (2) Calmodulin (3) COX (3) Cytochrome P450 (7) Dengue virus (2) Drug Metabolite (4) Endogenous Metabolite (11) Flavivirus (2) Fungal (1) Glucocorticoid Receptor (1) GnRH Receptor (1) Histamine Receptor (1) HSP (9) iGluR (1) Isotope-Labeled Compounds (6) Mitochondrial Metabolism (1) Monoamine Oxidase (1) Na+/K+ ATPase (1) NF-κB (4) Parasite (6) Phosphatase (1) Sodium Channel (1) STAT (2) Steroid Sulfatase (3) Topoisomerase (1) Tyrosinase (1)
By Research Areas:	Cancer (66) Cardiovascular Disease (5) Endocrinology (26) Infection (15) Inflammation/Immunology (11) Metabolic Disease (13) Neurological Disease (7)

By Targets:

Estrogen Receptor/ERR (62)

Androgen Receptor (1)

Apoptosis (14)

Autophagy (7)

Bacterial (7)

Calcium Channel (2)

Calmodulin (3)

COX (3)

Cytochrome P450 (7)

Dengue virus (2)

Drug Metabolite (4)

Endogenous Metabolite (11)

Flavivirus (2)

Fungal (1)

Glucocorticoid Receptor (1)

GnRH Receptor (1)

Histamine Receptor (1)

HSP (9)

iGluR (1)

Isotope-Labeled Compounds (6)

Mitochondrial Metabolism (1)

Monoamine Oxidase (1)

Na+/K+ ATPase (1)

NF-κB (4)

Parasite (6)

Phosphatase (1)

Sodium Channel (1)

STAT (2)

Steroid Sulfatase (3)

Topoisomerase (1)

Tyrosinase (1)

By Research Areas:

Cancer (66)

Cardiovascular Disease (5)

Endocrinology (26)

Infection (15)

Inflammation/Immunology (11)

Metabolic Disease (13)

Neurological Disease (7)

118

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Estrogen Receptor/ERR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2448

Lindleyin	Estrogen Receptor/ERR	Endocrinology
Lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors. Lindleyin binds to ERα with estrogenic activity .

HY-N6709

Zeranol α-Zearalanol	Estrogen Receptor/ERR	Endocrinology
Zeranol, a metabolite of the mycoestrogen zearalenone, is an estrogen receptor agonist. Zeranol is used as a growth promoter of livestock due to its strong estrogenic activity .

HY-N11707

Piscidic acid	Others	Others
Piscidic acid is an ester compound derived from Cimicifuga racemosa. Piscidic acid has in vitro estrogen activity .

HY-N11438

3'-Hydroxymirificin	Estrogen Receptor/ERR	Cancer
3'-Hydroxymirificin (compound 3) is a naural compound that can be isolated from Pueraria lobata roots. 3'-Hydroxymirificin (compound 3) possesses estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells .

HY-112746

Etacstil DPC974; GW5638	Estrogen Receptor/ERR	Cancer
Etacstil (GW5638) is a estrogen receptor antagonist that displays minimal uterotropic activity in ovariectomized rats and inhibits the agonist activity of Estradiol (HY-B0141), Tamoxifen (HY-13757A) and Raloxifene (HY-13738) in the environment. Etacstil is promising for research of breast cancer and bone protection .

HY-N6885

Puerarin-4'-O-β-D-glucopyranoside	Others	Cancer
Puerarin-4'-O-β-D-glucopyranoside (compound 8) is a isoflavone from Pueraria lobata root (PLR). Puerarin-4'-O-β-D-glucopyranoside has estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells .

HY-119088

Estrogen receptor modulator 12	Others	Others
Estrogen receptor modulator 12 (compound 1a-(R)) is a selective estrogen receptor modulator with estrogen agonist and antagonist activities in in vivo models. Estrogen receptor modulator 12 exhibits antagonist effects on the uterus and estrogen agonist activities on bone, plasma lipids, hot flashes, and vagina in in vivo models, and is a potential compound for suppressing postmenopausal symptoms.

HY-143253

Estrogen receptor antagonist 7	Estrogen Receptor/ERR	Cancer
Estrogen receptor antagonist 7 (compound 13) is a potent estrogen receptors (ER) antagonist. Estrogen receptor antagonist 7 has antiproliferative activity against breast and ovarian cancer cells. Anticancer and anti-uterotrophic activities .

HY-118242

RU 45144	Others	Others
RU 45144 is an anti-estrogen compound that has the activity of antagonizing the binding of estrogen receptors to calmodulin. RU 45144 can inhibit the binding of estrogen receptors to calmodulin, and its effect is similar to that of tamoxifen. Its anti-estrogen effect may be related to specific side chains in the molecular structure, and the steroid skeleton may be involved in its anti-proliferative activity.

HY-117649

RU-39411	Others	Cancer
RU-39411 is a steroidal anti-estrogen with mixed estrogenic/antiestrogen activity. RU-39411 has shown inhibitory effects on cell growth in the MCF-7 breast cancer model, with the effect being correlated with its binding affinity to the estrogen receptor. RU-39411 was able to downregulate the estrogen binding capacity of cells, but did not reduce estrogen receptor mRNA levels, indicating that the grafting of its side chain prevents the antagonistic effects usually associated with steroidal estrogens. The administration of RU-39411 can promote the synthesis of progesterone receptors, further supporting its activity as an estrogen .

HY-B1630

Stilbestrol dipropionate	Others	Cancer
Stilbestrol dipropionate is an estrogen-like compound with hormone suppressive activity for recurrent prostate cancer. Stilbestrol dipropionate can be used to suppress diseases associated with estrogen deficiency .

HY-106056

Zindoxifene D 16726	Others	Cancer
Zindoxifene is a partial anti-estrogen. Zindoxifene works primarily by binding to estrogen receptors, thereby inhibiting the growth of estrogen-dependent tumor cells. Zindoxifene is able to exhibit the dual properties of estrogen agonists and antagonists and can be used in research and development to target estrogen-dependent tumors, such as prostate and breast cancer .

HY-121236

Bavachromene	Others	Others
Bavachromene is a chromenochalcone from the seeds of Psoralea corylifolia with estrogenic activities .

HY-124882

Dienestrol diacetate	Others	Endocrinology
Dienestrol diacetate is a synthetic nonsteroidal phenolic compound with estrogenic activity. Dienestrol diacetate can mimic the effects of estrogen in vivo, affecting the reproductive system and other related biological processes. Dienestrol diacetate is being studied for the inhibition of hormone-related diseases, such as estrogen deficiency. Dienestrol diacetate's potential applications also include possible use in hormone replacement therapy .

HY-N9329

Glicoricone	Monoamine Oxidase Estrogen Receptor/ERR	Metabolic Disease
Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC₅₀ of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity .

HY-164463

BMI-135	Estrogen Receptor/ERR Apoptosis	Cancer
BMI-135 is a selective estrogen mimic, that exhibits agonist activity for estrogen receptor. BMI-135 induces rapid endoplasmic reticulum stress response (UPR) and apoptosis in breast cancer cells .

HY-145716

Nafoxidine Nafoxidene	Estrogen Receptor/ERR	Cancer
Nafoxidine, a nonsteroidal estrogen antagonist, is shown to possess antitumor activity against breast cancer.

HY-16023B

(Rac)-Acolbifene EM-343; (Rac)-EM-652	Estrogen Receptor/ERR	Cancer
(Rac)-Acolbifene (EM-343; (Rac)-EM-652) is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities. (Rac)-Acolbifene (EM-343; (Rac)-EM-652) contains a piperidine ring, shows good pharmacological profile,relative binding affinity (RBA)=380 .

HY-B2158

Chlorotrianisene	Estrogen Receptor/ERR COX	Cardiovascular Disease Endocrinology
Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood .

HY-125703

Ferutinin	Estrogen Receptor/ERR Apoptosis	Infection Inflammation/Immunology Endocrinology Cancer
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC₅₀s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca ²⁺-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities .

HY-107245

Segetalin B 1 Publications Verification	Estrogen Receptor/ERR	Metabolic Disease
Segetalin B, a cyclopentapeptide from Vaccaria segetalis, possesses estrogen-like activity .

HY-N7128

Flavanone	Cytochrome P450	Cancer
Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase) .

HY-W040046

Nafoxidine hydrochloride Nafoxidene hydrochloride	Estrogen Receptor/ERR	Cancer
Nafoxidine hydrochloride is a non-steroidal estrogen receptor antagonist with antitumor activity for breast cancer .

HY-B2158S

Chlorotrianisene-d9	Estrogen Receptor/ERR COX	Cardiovascular Disease Endocrinology
Chlorotrianisene-d₉ is the deuterium labeled Chlorotrianisene. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood[1][2][3].

HY-149969

ER degrader 4	Estrogen Receptor/ERR	Cancer
ER degrader 4 is a selective and orally active estrogen receptor degrader. ER degrader 4 has anti-tumor activity .

HY-B2158R

Chlorotrianisene (Standard)	Estrogen Receptor/ERR COX	Cardiovascular Disease Endocrinology
Chlorotrianisene (Standard) is the analytical standard of Chlorotrianisene. This product is intended for research and analytical applications. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood .

HY-B0487

Ethisterone Pregneninolone; 17α-Ethynyltestosterone	Estrogen Receptor/ERR	Endocrinology
Ethisterone (Pregneninolone), a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone is reported for androgenic activity, used for the research of the gynecological disorders .

HY-N3943

Glabrene	Tyrosinase	Neurological Disease
Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a tyrosinase inhibitor with an IC₅₀ of 3.5 μM .

HY-13757A

Tamoxifen Maximum Cited Publications 111 Publications Verification ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen	Estrogen Receptor/ERR HSP Autophagy Apoptosis	Cancer
Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse .

HY-N6714

Alternariol	Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis	Infection Cancer
Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .

HY-13757

Tamoxifen Citrate Maximum Cited Publications 111 Publications Verification ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate	Estrogen Receptor/ERR HSP Autophagy Apoptosis	Cancer
Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells .Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .

HY-111484A

GDC-0927 Racemate SRN-927 Racemate	Estrogen Receptor/ERR	Cancer
GDC-0927 Racemate (SRN-927 Racemate) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC₅₀ of 0.2 nM, and is used in the research of ER-related diseases.

HY-B0887

Permethrin 1 Publications Verification NRDC-143	Parasite Mitochondrial Metabolism Sodium Channel Na+/K+ ATPase	Infection Neurological Disease
Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows *estrogenic* in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes) .

HY-18719B

Endoxifen hydrochloride 1 Publications Verification	Cytochrome P450 Estrogen Receptor/ERR Drug Metabolite Parasite	Cancer
Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer study .

HY-18719E

Endoxifen 1 Publications Verification	Cytochrome P450 Estrogen Receptor/ERR Drug Metabolite Parasite	Cancer
Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study .

HY-124489

2-Hydroxyestradiol	Endogenous Metabolite	Metabolic Disease
2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-N7128R

Flavanone (Standard)	Cytochrome P450	Cancer
Flavanone (Standard) is the analytical standard of Flavanone. This product is intended for research and analytical applications. Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase) .

HY-103455

ZK164015	Others	Others
ZK164015 is an estrogen-glucocorticoid receptor chimera that can be used as a compound screening tool to evaluate tissue-selective estrogen activity. ZK164015 was used to evaluate its effects on ER function in osteoblasts in studies based on green fluorescent protein (GFP)-receptor chimeras. In osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cells, ZK164015 showed different effects in response to ER agonists, including modulation of ERE-luc activity and effects on nuclear mobility.

HY-13757AS1

Tamoxifen-d3 ICI 47699-d₃; (Z)-Tamoxifen-d₃; trans-Tamoxifen-d₃	Estrogen Receptor/ERR Apoptosis Autophagy HSP	Cancer
Tamoxifen-d₃ is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].

HY-13757AR

Tamoxifen (Standard) 100+ Cited Publications ICI 47699(Standard); (Z)-Tamoxifen(Standard); trans-Tamoxifen (Standard)	Estrogen Receptor/ERR HSP Autophagy Apoptosis	Cancer
Tamoxifen (Standard) is the analytical standard of Tamoxifen. This product is intended for research and analytical applications. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse .

HY-N7504

Isopsoralenoside	Bacterial	Infection Metabolic Disease Cancer
Isopsoralenoside is a benzofuran glycoside from Psoralea corylifolia. Isopsoralenoside can be quickly metabolized to Psoralen (HY-N0053) in digestive tract contents. Isopsoralenoside show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

HY-18295

Erteberel 2 Publications Verification LY500307	Estrogen Receptor/ERR	Neurological Disease
Erteberel (LY500307) is a potent and selective estrogen receptor beta (ERβ) agonist with K_i and EC₅₀ of 1.54 nM and 3.61 nM, respectively. Erteberel has anti-tumor activities .

HY-117726

WAY-169916	Estrogen Receptor/ERR NF-κB	Inflammation/Immunology
WAY-169916 is a pathway-selective ligand of ER (estrogen receptor) that acts by inhibiting NF-kB transcriptional activity. WAY-169916 has potent anti-inflammatory effect .

HY-149970

ER degrader 5	Estrogen Receptor/ERR	Cancer
ER degrader 5 is a potent estrogen receptor (ER) degrader. ER degrader 5 shows anti-proliferation activity. ER degrader 5 can be used for the research of breast cancer .

HY-131122S

4-Nonylphenol-D5 4-n-Nonylphenol-2,3,5,6-d4,OD	Estrogen Receptor/ERR	Others
4-Nonylphenol-d₅ is the deuterium labeled 4-Nonylphenol. 4-Nonylphenol, a major degradation product of Nonylphenol ethoxylates (NPEOs), is a persistent organic pollutant with endocrine-disrupting properties and exerts estrogenic activity[1].

HY-125091

LY2066948	Estrogen Receptor/ERR	Cancer
LY2066948 is a selective and orally active estrogen receptor modulator (SERM). LY2066948 has high affinity for estrogen receptors ERα and ERβ (K_i: 0.51 and 1.36 nM respectively) and shows potent antiestrogenic activity. LY2066948 blocks uterine weight gain induced by Ethynyl estradiol (HY-B0216) in immature rats. LY2066948 can be used for research of uterine fibroids and myomas .

HY-143226

DK1	Estrogen Receptor/ERR	Metabolic Disease
DK1 is a potent modulator of estrogen related receptor. DK1 has an ability in reducing blood glucose, and impacts the activity of ERRα receptor. DK1 has the potential for the research of diabetes .

HY-W087008

7-Hydroxyflavanone	Cytochrome P450	Endocrinology Cancer
7-Hydroxyflavanone is a potent inhibitor of aromatase (CYP19) activity with the IC₅₀ of 65 μM. 7-Hydroxyflavanone exerts various biological effects, including anticarcinogenic, antioxidant and (anti-)estrogenic effects, and modula

HY-147402

Taragarestrant D-0502	Estrogen Receptor/ERR	Cancer
Taragarestrant (D-0502) is a potent, orally active and selective estrogen receptor degrader (SERD). Taragarestrant shows potent activity in various ER+ breast cancer cell lines and xenograft models .

HY-W150752

Triphenylethylene	Estrogen Receptor/ERR Calcium Channel	Endocrinology
Triphenylethylene is an aromatic hydrocarbon that possesses weak estrogenic activity. Triphenylethylene antiestrogens relax duodenal intestinal muscle via a mechanism that involves inhibition of L-type Ca ²⁺ channels but not activation of K ⁺ channels .

Cat. No.	Product Name

HY-L074

Anti-Breast Cancer Compound Library

2,029 compounds

Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC).

Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer.

MCE supplies a unique collection of 2,029 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Cat. No.	Product Name	Type

HY-W250978

Ovalbumins 1 Publications Verification	Native Proteins
Ovalbumins (OVA), the main protein found in egg whites, have various biological activities such as anticancer, antihypertensive, antibacterial, antioxidant and immunomodulatory activities. Ovalbumins are the most abundant proteins synthesized in progesterone- or estrogen-treated fallopian tubes and are commonly used as markers to study hormone regulation of gene expression in tissues. .

HY-W699238

S-(-)-Aminoglutethimide D-tartrate

Cell Assay Reagents

S-(-)-Aminoglutethimide D-tartrate is an aromatase inhibitor with activity that blocks adrenal steroidogenesis. S-(-)-Aminoglutethimide D-tartrate can be used to inhibit steroid-related diseases. S-(-)-Aminoglutethimide D-tartrate is often used clinically to control certain types of cancer. S-(-)-Aminoglutethimide D-tartrate effectively reduces testosterone and estrogen levels through an enzyme inhibition mechanism.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2448

Lindleyin	Classification of Application Fields Rheum palmatum L. Polygonaceae Source classification Phenols Polyphenols Plants Disease Research Fields Endocrinology	Estrogen Receptor/ERR
Lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors. Lindleyin binds to ERα with estrogenic activity .

HY-N9329

Glicoricone	Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones	Monoamine Oxidase Estrogen Receptor/ERR
Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC₅₀ of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity .

HY-125703

Ferutinin	Viguiera dentata (Cav.) Spreng. Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Umbelliferae Plants Disease Research Fields Endocrinology Cancer	Estrogen Receptor/ERR Apoptosis
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC₅₀s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca ²⁺-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities .

HY-107245

Segetalin B 1 Publications Verification	Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Cyclopeptides Source classification Metabolic Disease Plants Disease Research Fields Caryophyllaceae	Estrogen Receptor/ERR
Segetalin B, a cyclopentapeptide from Vaccaria segetalis, possesses estrogen-like activity .

HY-N7128

Flavanone	Structural Classification Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Sophora flavescens Aiton Plants Disease Research Fields Cancer	Cytochrome P450
Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase) .

HY-N11707

Piscidic acid	Structural Classification Cactaceae Ketones, Aldehydes, Acids Source classification Opuntia ficus-indica (L.) Mill. Plants	Others
Piscidic acid is an ester compound derived from Cimicifuga racemosa. Piscidic acid has in vitro estrogen activity .

HY-N11438

3'-Hydroxymirificin	Structural Classification Flavonoids Flavones Leguminosae Source classification Pueraria montana (Loureiro) Merrill Plants	Estrogen Receptor/ERR
3'-Hydroxymirificin (compound 3) is a naural compound that can be isolated from Pueraria lobata roots. 3'-Hydroxymirificin (compound 3) possesses estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells .

HY-N6885

Puerarin-4'-O-β-D-glucopyranoside	Flavonoids Monophenols Classification of Application Fields Leguminosae Source classification Phenols Pueraria montana (Loureiro) Merrill Plants Disease Research Fields Isoflavones Cancer	Others
Puerarin-4'-O-β-D-glucopyranoside (compound 8) is a isoflavone from Pueraria lobata root (PLR). Puerarin-4'-O-β-D-glucopyranoside has estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells .

HY-121236

Bavachromene	Flavonoids Chalcones Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields	Others
Bavachromene is a chromenochalcone from the seeds of Psoralea corylifolia with estrogenic activities .

HY-N3943

Glabrene	Stilbenes Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch.	Tyrosinase
Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a tyrosinase inhibitor with an IC₅₀ of 3.5 μM .

HY-N6714

Alternariol	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis
Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .

HY-124489

2-Hydroxyestradiol	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-N7128R

Flavanone (Standard)	Structural Classification Flavonoids Leguminosae Flavonones Source classification Sophora flavescens Aiton Plants	Cytochrome P450
Flavanone (Standard) is the analytical standard of Flavanone. This product is intended for research and analytical applications. Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase) .

HY-N7504

Isopsoralenoside	Infection Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Metabolic Disease Psoralea corylifolia L. Plants Disease Research Fields	Bacterial
Isopsoralenoside is a benzofuran glycoside from Psoralea corylifolia. Isopsoralenoside can be quickly metabolized to Psoralen (HY-N0053) in digestive tract contents. Isopsoralenoside show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

HY-W087008

7-Hydroxyflavanone	Dalbergia cochinchinensis Monophenols Source classification Papilionaceae Phenols Plants Disease Research Fields Endocrinology Cancer	Cytochrome P450
7-Hydroxyflavanone is a potent inhibitor of aromatase (CYP19) activity with the IC₅₀ of 65 μM. 7-Hydroxyflavanone exerts various biological effects, including anticarcinogenic, antioxidant and (anti-)estrogenic effects, and modula

HY-N2682B

Dehydrodiconiferyl alcohol	Structural Classification Monophenols Cucurbita moschata Source classification Cucurbitaceae Phenols Plants	Estrogen Receptor/ERR
Dehydrodiconiferyl alcohol is an estrogen receptor agonist that can promote BMP-2-induced osteoblastogenesis. Dehydrodiconiferyl alcohol also exerts anti-inflammatory activity through inactivation of NF-κB pathways .

HY-N0250

Saikosaponin D 3 Publications Verification	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Umbelliferae Plants Inflammation/Immunology Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	STAT NF-κB Estrogen Receptor/ERR Bacterial
Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.

HY-N12023

Deacetylnomilin	Triterpenes Structural Classification Natural Products Terpenoids Source classification Rutaceae Plants Citrus reticulata Blanco	Bacterial Fungal
Deacetylnomilin can be isolated from Citrus reticulata and has antibacterial and antifungal activity. Deacetylnomilin is a potent inhibitor of cell proliferation with an IC₅₀ value of 0.005 ug/mL against estrogen receptor-positive (ER+) cells .

HY-N1581

Quassin Nigakilactone D	Triterpenes Structural Classification Simaroubaceae Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Picrasma quassioides(D．Don)Benn． Endocrinology	Parasite
Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits *P. falciparum* with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

HY-103447

Zearalenone Maximum Cited Publications 7 Publications Verification Mycotoxin F2; Toxin F2	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Polyphenols Disease Research Fields	Estrogen Receptor/ERR
Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-N7503

Psoralenoside	Infection Structural Classification Classification of Application Fields Simple Phenylpropanols Leguminosae Source classification Metabolic Disease Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields	Histamine Receptor Calcium Channel Calmodulin
Psoralenoside is a benzofuran glycoside from Psoralea corylifolia . Psoralenoside exhibits high binding affinities against histaminergic H₁, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol) . Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

HY-108692

Enterolactone	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Lignans Phenylpropanoids Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

HY-N11973

5,7-Dimethoxy-2,3-phenanthrenediol	Structural Classification Dioscorea polystachya Turczaninow Source classification Phenols Polyphenols Plants Dioscoreaceae	Others
5,7-Dimethoxy-2,3-phenanthrenediol is a compound with *estrogenic* activity. 5,7-Dimethoxy-2,3-phenanthrenediol increases the proliferation of MCF-7 cell and the expression of ERβ in the MCF-7 cell line .

HY-30270

Mequinol p-Hydroxyanisole	Structural Classification Monophenols Classification of Application Fields Source classification Mercurialis Other Diseases Phenols Euphorbiaceae Plants Disease Research Fields	HSP Estrogen Receptor/ERR
Mequinol (4-Methoxyphenol)yes MercurialisOne of the bioactive ingredients, mainly used for skin discoloration . MequinolIs an antioxidant that has additive/synergistic effects on carcinogenesis when combined with other phenolic antioxidants. Mequinolalso promote hERαDependent chaperone production with potential estrogenic activity .

HY-103447R

Zearalenone (Standard) Mycotoxin F2(Standard); Toxin F2 (Standard)	Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Estrogen Receptor/ERR
Zearalenone (Standard) is the analytical standard of Zearalenone. This product is intended for research and analytical applications. Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-N0250R

Saikosaponin D (Standard)	Triterpenes Structural Classification Terpenoids Source classification Umbelliferae Plants Carphephorus corymbosus (Nutt.) Torr. & A.Gray	STAT NF-κB Estrogen Receptor/ERR Bacterial
Saikosaponin D (Standard) is the analytical standard of Saikosaponin D. This product is intended for research and analytical applications. Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.

HY-N1581R

Quassin (Standard)	Triterpenes Structural Classification Simaroubaceae Terpenoids Source classification Plants Picrasma quassioides(D．Don)Benn．	Parasite
Quassin (Standard) is the analytical standard of Quassin. This product is intended for research and analytical applications. Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

HY-N10403

4-Hydroxyestradiol 4-Hydroxy-17β-estradiol	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Steroids Cancer	Drug Metabolite Endogenous Metabolite
4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141). 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a K_i of 0.48 nM .

HY-W009300

4-Hydroxyestrone 1 Publications Verification 4-OHE1	Structural Classification Natural Products Animals Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity .

HY-30270R

Mequinol (Standard)	Structural Classification Monophenols Source classification Mercurialis Phenols Euphorbiaceae Plants	HSP Estrogen Receptor/ERR
Mequinol (Standard) is the analytical standard of Mequinol. This product is intended for research and analytical applications. Mequinol (4-Methoxyphenol)yes MercurialisOne of the bioactive ingredients, mainly used for skin discoloration . MequinolIs an antioxidant that has additive/synergistic effects on carcinogenesis when combined with other phenolic antioxidants. Mequinolalso promote hERαDependent chaperone production with potential estrogenic activity .

HY-N0367

Trans-Anethole 2 Publications Verification (E)-Anethole	Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Umbelliferae Plants Endogenous metabolite Vernonia Schreb. Disease Research Fields Cancer	Endogenous Metabolite
Trans-Anethole ((E)-Anethole) is an orally active phenylpropene derivative found in Foeniculum vulgare that is estrogenic at low concentrations and cytotoxic at high concentrations in tumor cell lines. Trans-Anethole also has anti-aflatoxin, anti-thrombotic and anti-diabetic activities. Trans-Anethole is an important odor component in plants such as fennel, myrtle, liquorice, and camphor .

HY-N0367R

Trans-Anethole (Standard)	Structural Classification Simple Phenylpropanols Source classification Phenylpropanoids Umbelliferae Plants Endogenous metabolite Vernonia Schreb.	Endogenous Metabolite
Trans-Anethole (Standard) is the analytical standard of Trans-Anethole. This product is intended for research and analytical applications. Trans-Anethole ((E)-Anethole) is an orally active phenylpropene derivative found in Foeniculum vulgare that is estrogenic at low concentrations and cytotoxic at high concentrations in tumor cell lines. Trans-Anethole also has anti-aflatoxin, anti-thrombotic and anti-diabetic activities. Trans-Anethole is an important odor component in plants such as fennel, myrtle, liquorice, and camphor .

HY-119539

Limocitrin	Structural Classification Flavonols Flavonoids Source classification Plants Platanaceae Platanus orientalis L.	Phosphatase
Limocitrin is a natural product that can be isolated from the buds of P. acerifolia and P. orientalis. Limocitrin suppresses estradiol-dependent proliferation of MCF7 cells weakly but estradiol-induced AlkP (alkaline phosphatase) expression only marginally .

Cat. No.	Product Name	Chemical Structure

HY-131122S

4-Nonylphenol-D5
4-Nonylphenol-d₅ is the deuterium labeled 4-Nonylphenol. 4-Nonylphenol, a major degradation product of Nonylphenol ethoxylates (NPEOs), is a persistent organic pollutant with endocrine-disrupting properties and exerts estrogenic activity[1].

HY-13757S

Tamoxifen-d3 hydrochloride

Tamoxifen-d₃ hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells .Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .

HY-13757AS

Tamoxifen-d5
Tamoxifen-d₅ is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].

HY-108692S

Enterolactone-d6
Enterolactone-d₆ is the deuterium labeled Enterolactone. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].

HY-124489S1

2-Hydroxyestradiol-d5
2-Hydroxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[[1][3][4].

HY-B2158S

Chlorotrianisene-d9
Chlorotrianisene-d₉ is the deuterium labeled Chlorotrianisene. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood[1][2][3].

HY-13757AS1

Tamoxifen-d3

Tamoxifen-d₃ is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].

HY-18719ES

Endoxifen-d5
Endoxifen-d₅ is the deuterium labeled Endoxifen. Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study[1][2].

HY-124489S

2-Hydroxyestradiol-13C6
2-Hydroxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[1][3].

HY-103447S

(Rac)-Zearalenone-d6
(Rac)-Zearalenone-d₆ is the deuterium labled Zearalenone (HY-103447). Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-B1805S

Triclocarban-d4

Triclocarban-d₄ is the deuterium labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes[1][2][3].

HY-103447S1

Zearalenone-13C18
Zearalenone- ¹³C₁₈ (Mycotoxin F2- ¹³C₁₈; Toxin F2- ¹³C₁₈) is the ¹³C labeled Zearalenone (HY-103447) . Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-N0368S2

Linalool-d6

Linalool-d₆ is deuterated labeled Trans-Anethole (HY-N0367). Trans-Anethole ((E)-Anethole), a phenylpropene derivative isolated from Foeniculum vulgare, shows estrogenic activity at lower concentrations and cytotoxic at higher concentrations in cancer cell lines . Trans-Anethole ((E)-Anethole) contributes a large component of the odor and flavor of anise and fennel, anise myrtle, liquorice, camphor, magnolia blossoms, and star anise .

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