LY2066948

Cat. No.: HY-125091: FAQs
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LY2066948 is a selective and orally active estrogen receptor modulator (SERM). LY2066948 has high affinity for estrogen receptors ERα and ERβ (K_i: 0.51 and 1.36 nM respectively) and shows potent antiestrogenic activity. LY2066948 blocks uterine weight gain induced by Ethynyl estradiol (HY-B0216) in immature rats. LY2066948 can be used for research of uterine fibroids and myomas.

For research use only. We do not sell to patients.

LY2066948 Chemical Structure

CAS No. : 648904-56-7

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View All Estrogen Receptor/ERR Isoform Specific Products:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Ishikawa	IC₅₀	10.7 nM Compound: 4b	Inhibition of estrogen stimulation in human Ishikawa cells by alkaline phosphatase quantitation Inhibition of estrogen stimulation in human Ishikawa cells by alkaline phosphatase quantitation	[PMID: 17482463]

Molecular Weight

517.64

Formula

C₃₀H₃₁NO₅S

CAS No.

648904-56-7

SMILES

OC1=CC=C2C(OC3=CC=C(C=C3)OCCN4CCCCC4)=C(C=CC2=C1)C5=CC=C(C=C5)S(=O)(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gherezghiher TB, et al. The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin. Chem Biol Interact. 2012 Mar 5;196(1-2):1-10. [Content Brief]

[2]. Geiser AG, et al. A new selective estrogen receptor modulator with potent uterine antagonist activity, agonist activity in bone, and minimal ovarian stimulation. Endocrinology. 2005 Oct;146(10):4524-35. [Content Brief]

LY2066948 Related Classifications

Cancer

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY2066948648904-56-7LY 2066948LY-2066948Estrogen Receptor/ERRuterine fibroidsmyomasInhibitorinhibitorinhibit

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