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  4. (E,E)-GLL398

(E,E)-GLL398 is a selective estrogen receptor degrader with potent binding activity to ERα (IC50 = 1.14 nM). (E,E)-GLL398 can effectively degrade ERα in MCF-7 breast cancer cells (IC50 = 0.21 μM). The introduced boronic acid group of (E,E)-GLL398 gives it superior oral bioavailability, with an AUC of 36.9 μg·h/mL in rats, which is significantly higher than that of GW7604.

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(E,E)-GLL398 Chemical Structure

(E,E)-GLL398 Chemical Structure

CAS No. : 2077980-83-5

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(E,E)-GLL398 Related Antibodies

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Description

(E,E)-GLL398 is a selective estrogen receptor degrader with potent binding activity to ERα (IC50 = 1.14 nM). (E,E)-GLL398 can effectively degrade ERα in MCF-7 breast cancer cells (IC50 = 0.21 μM). The introduced boronic acid group of (E,E)-GLL398 gives it superior oral bioavailability, with an AUC of 36.9 μg·h/mL in rats, which is significantly higher than that of GW7604[1].

Molecular Weight

398.26

Formula

C25H23BO4
CAS No.
SMILES

O=C(/C=C/C1=CC=C(C=C1)/C(C2=CC=C(C=C2)B(O)O)=C(CC)/C3=CC=CC=C3)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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(E,E)-GLL398 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

(E,E)-GLL3982077980-83-5OthersInhibitorinhibitorinhibit

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