2. Anti-infection Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Parasite Mitochondrial Metabolism Sodium Channel Na+/K+ ATPase
  4. Permethrin

Permethrin  (Synonyms: NRDC-143)

Cat. No.: HY-B0887 Purity: ≥98.0%
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Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes).

For research use only. We do not sell to patients.

Permethrin Chemical Structure

Permethrin Chemical Structure

CAS No. : 52645-53-1

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 39 In-stock
Solution
10 mM * 1 mL in DMSO USD 39 In-stock
Liquid
100 mg USD 35 In-stock
500 mg USD 75 In-stock
1 g USD 110 In-stock
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10 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Permethrin:

Permethrin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Permethrin

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes)[1][2][3][4][5][6][7].

In Vitro

Permethrin (25 μM, 1 h) dose-dependently decreases the activity of total ATPase and the activity of Na+, K+-ATPase in vitro[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Permethrin Related Antibodies
In Vivo

Permethrin (50, 500 and 5000 μg/kg BW, Dietary intake, daily for 12 weeks) promotes weight gain, total adipose tissue weight and aggravates high fat dietinduced insulin resistance along with high fat diet, but significantly decreases pAMPKα and pAMPKα/AMPKα expression in mouse[1].
Permethrin (0.1, 1, 10 µg/L, aqueous solution, 14 days) has higher relative expression of choriogenin (Chg) than the 1 ng/L Ethinylestradiol (EE2) (HY-B0216) treatment, and lower relative expression than the 10 ng/L EE2 treatment in Juvenile Menidia beryllina[6].
Permethrin (500 and 1000 mg/kg, diet mixed, daily for 14 days) has memory and spatial exploration dwindling effect, but no effects on anxiety and locomotion in rats [7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice at three weeks of age[1]
Dosage: 50, 500 and 5000 μg/kg BW
Administration: dietary intake with low and high fat diets, daily for 12 weeks
Result: Significantly increased body weight gain in high fat diet-fed group by 56% in mice.
Animal Model: Male Wistar rats weighing between 130-135 g[7]
Dosage: 500, 1000 mg/kg
Administration: diet mixed with permethrin insecticide for 14 days
Result: Induced the poorer the memory indices in all behavioral paradigms with high doses in rats.
Clinical Trial
Molecular Weight

391.29

Formula

C21H20Cl2O3
CAS No.
Appearance

Liquid (Density: 1.19 g/cm3)

Color

Light yellow to yellow

SMILES

O=C(C1C(C)(C)C1/C=C(Cl)\Cl)OCC2=CC=CC(OC3=CC=CC=C3)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (127.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5556 mL 12.7782 mL 25.5565 mL
5 mM 0.5111 mL 2.5556 mL 5.1113 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.39 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (6.39 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5556 mL 12.7782 mL 25.5565 mL 63.8912 mL
5 mM 0.5111 mL 2.5556 mL 5.1113 mL 12.7782 mL
10 mM 0.2556 mL 1.2778 mL 2.5556 mL 6.3891 mL
15 mM 0.1704 mL 0.8519 mL 1.7038 mL 4.2594 mL
20 mM 0.1278 mL 0.6389 mL 1.2778 mL 3.1946 mL
25 mM 0.1022 mL 0.5111 mL 1.0223 mL 2.5556 mL
30 mM 0.0852 mL 0.4259 mL 0.8519 mL 2.1297 mL
40 mM 0.0639 mL 0.3195 mL 0.6389 mL 1.5973 mL
50 mM 0.0511 mL 0.2556 mL 0.5111 mL 1.2778 mL
60 mM 0.0426 mL 0.2130 mL 0.4259 mL 1.0649 mL
80 mM 0.0319 mL 0.1597 mL 0.3195 mL 0.7986 mL
100 mM 0.0256 mL 0.1278 mL 0.2556 mL 0.6389 mL
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Permethrin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Permethrin52645-53-1NRDC-143NRDC143NRDC 143ParasiteMitochondrial MetabolismSodium ChannelNa+/K+ ATPaseNa channelsNa+ channelsSodium potassium pumpInhibitorinhibitorinhibit

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