Enterolactone

Cat. No.: HY-108692: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis.

For research use only. We do not sell to patients.

Enterolactone Chemical Structure

CAS No. : 78473-71-9

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1 mg		Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Enterolactone:

Enterolactone-d₆ Get quote
Enterolactone (Standard) Get quote

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Biological Activity
Purity & Documentation
References
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Description

Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity^[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	23.5 μM Compound: Zerumboneoxide	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells measured after 20 hrs by Griess assay Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells measured after 20 hrs by Griess assay	[PMID: 30096653]

In Vitro

Enterolactone (25-75 μM; 48 hours) arrests the growth of MDA-MB-231 breast cancer cells in the ‘S’ phase^[1]
Enterolactone (25-75 μM; 15 hours) triggers apoptosis in MDA-MB-231 breast cancer cells via caspase-3 activation^[1].
Enterolactone inhibits TGF-β-induced migration of MDA-MB-231 breast cancer cells. Enterolactone inhibits TGF-β-induced invasion of MDA-MB-231 breast cancer cells through ECM. Enterolactone inhibits the TGF-β-induced EMT program in MDA-MB-231 breast cancer cells. Enterolactone reduces the formation of actin stress fibers by inhibiting the expression of CD44 and MAPK-p38. Enterolactone inhibits the ERK/NF-κB/Snail signaling pathway to revert TGF-β-induced EMT in MDA-MB-231 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	25, 50, 75 μM
Incubation Time:	48 hours
Result:	There was a non-significant increase (~24%) in the S phase population following treatment with 25 μM EL, whereas there were significant increases (~34% and ~39%) following treatment with 50 and 75 μM EL, respectively.

Molecular Weight

298.33

Formula

C₁₈H₁₈O₄

CAS No.

78473-71-9

Appearance

Solid

Color

White to off-white

SMILES

O=C1OC[C@H](CC2=CC=CC(O)=C2)[C@H]1CC3=CC=CC(O)=C3

Structure Classification

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 30 mg/mL (100.56 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3520 mL	16.7600 mL	33.5199 mL
5 mM	0.6704 mL	3.3520 mL	6.7040 mL
10 mM	0.3352 mL	1.6760 mL	3.3520 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (281 KB) SDS (393 KB)

COA (258 KB)

Handling Instructions (2659 KB)

References

[1]. Bigdeli B, et al. Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicol Appl Pharmacol. 2016;313:180-194. [Content Brief]

[2]. Mali AV, et al. Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial-mesenchymal transition. Cancer Biol Med. 2018;15(2):137-156. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3520 mL	16.7600 mL	33.5199 mL	83.7998 mL
	5 mM	0.6704 mL	3.3520 mL	6.7040 mL	16.7600 mL
	10 mM	0.3352 mL	1.6760 mL	3.3520 mL	8.3800 mL
	15 mM	0.2235 mL	1.1173 mL	2.2347 mL	5.5867 mL
	20 mM	0.1676 mL	0.8380 mL	1.6760 mL	4.1900 mL
	25 mM	0.1341 mL	0.6704 mL	1.3408 mL	3.3520 mL
	30 mM	0.1117 mL	0.5587 mL	1.1173 mL	2.7933 mL
	40 mM	0.0838 mL	0.4190 mL	0.8380 mL	2.0950 mL
	50 mM	0.0670 mL	0.3352 mL	0.6704 mL	1.6760 mL
	60 mM	0.0559 mL	0.2793 mL	0.5587 mL	1.3967 mL
	80 mM	0.0419 mL	0.2095 mL	0.4190 mL	1.0475 mL
	100 mM	0.0335 mL	0.1676 mL	0.3352 mL	0.8380 mL

Enterolactone Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enterolactone78473-71-9ApoptosisEndogenous Metabolitetriplenegativebreastcancer,celllineMDA-MB-231epithelialmesenchymaltransitioninvasionInhibitorinhibitorinhibit

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