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Results for "

muscarinic M3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mAChR (67) 5-HT Receptor (2) Adrenergic Receptor (5) Akt (3) Calcium Channel (2) Cholinesterase (ChE) (1) Histamine Receptor (1) p38 MAPK (3) Parasite (1) Prolyl Endopeptidase (PREP) (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (6) Endocrinology (1) Inflammation/Immunology (11) Metabolic Disease (11) Neurological Disease (52)
Click Chemistry:	Alkynes (2)

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Targets Recommended: mAChR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-U00302

CHF5407	mAChR	Inflammation/Immunology
CHF5407 is a selective, long-acting and competitive muscarinic M3 receptor antagonist. CHF5407 shows subnanomolar affinities for human muscarinic M1 (hM1), M2 (hM2) and M3 (hM3) receptors. CHF5407 shows a prolonged antibronchospastic activity .

HY-107649

Zamifenacin fumarate UK-76654 fumarate	mAChR	Metabolic Disease
Zamifenacin fumarate (UK-76654 fumarate) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome .

HY-123337

Zamifenacin UK-76654	mAChR	Metabolic Disease
Zamifenacin (UK-76654) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome .

HY-100234

DREADD agonist 21 1 Publications Verification	mAChR	Neurological Disease
DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC₅₀=1.7 nM) .

HY-100234A

DREADD agonist 21 dihydrochloride 1 Publications Verification	mAChR	Neurological Disease
DREADD agonist 21 dihydrochloride is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC₅₀=1.7 nM) .

HY-B0726

Pilocarpine Hydrochloride Maximum Cited Publications 29 Publications Verification	mAChR	Cardiovascular Disease Neurological Disease Cancer
Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B0726A

Pilocarpine Maximum Cited Publications 29 Publications Verification	mAChR	Neurological Disease Cancer
Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B1006

Pilocarpine nitrate Maximum Cited Publications 29 Publications Verification	mAChR	Neurological Disease Cancer
Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-113692

AZD-9164 bromide	Others	Others
AZD-9164 (bromide) is a long-acting muscarinic M3 antagonist. AZD-9164 (bromide) is promising for research of airways diseases, such as chronic obstructive pulmonary disease (COPD) or asthma .

HY-15502

PF-3635659	mAChR	Neurological Disease Inflammation/Immunology
PF-3635659 is a potent antagonist of the muscarinic M3 receptor (mAChR3). PF-3635659 can be used for chronic obstructive pulmonary disease (COPD) research .

HY-167849

Sofpironium tosylate BBI-4000 tosylate	mAChR	Neurological Disease
Sofpironium (BBI 4000) tosylate is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium tosylate reduces sweating by inhibiting *M3 muscarinic* receptors** in eccrine glands at the application site. Sofpironium tosylate also has a high afnity for the M1, M2, M4 and M5 subtypes .

HY-109013

Sofpironium bromide BBI 4000	mAChR	Neurological Disease
Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting *M3 muscarinic* receptors** in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes .

HY-B0726R

Pilocarpine Hydrochloride (Standard)	mAChR	Neurological Disease Cancer
Pilocarpine (Hydrochloride) (Standard) is the analytical standard of Pilocarpine (Hydrochloride). This product is intended for research and analytical applications. Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B1006R

Pilocarpine nitrate (Standard)	mAChR	Neurological Disease Cancer
Pilocarpine (nitrate) (Standard) is the analytical standard of Pilocarpine (nitrate). This product is intended for research and analytical applications. Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-107647

(S)-(+)-Dimethindene maleate	mAChR Histamine Receptor	Inflammation/Immunology
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M₂-selective muscarinic receptor antagonist (pA₂ = 7.86/7.74; pK_i = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M₁ (pA₂ = 6.83/6.36; pK_i = 7.08), the M₃ (pA₂ = 6.92/6.96; pK_i = 6.70) and the M₄ receptors (pK_i = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H₁ receptor antagonist (pA₂ = 7.48) .

HY-22437

(±)-Darifenacin (±)-UK-88525	mAChR	Neurological Disease Cancer
(±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective M3 muscarinic receptor antagonist .

HY-A0033

Darifenacin 5 Publications Verification UK-88525	mAChR p38 MAPK Akt	Neurological Disease Metabolic Disease Cancer
Darifenacin (UK-88525) is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9. Darifenacin binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin inhibits tumor growth in colorectal cancer cells and has anti-tumor effects .

HY-P4156

VLVNTFCDSCIPKTYWNLGY TFA	mAChR	Neurological Disease
VLVNTFCDSCIPKTYWNLGY TFA is an antigenic peptide of M3 muscarinic receptor (M3R). VLVNTFCDSCIPKTYWNLGY TFA can be used in ELISA .

HY-115413

LG50643	mAChR	Neurological Disease
LG50643 is a potent and selective *M3 muscarinic* receptor antagonist (pK_i**=8.64).

HY-A0030

Fesoterodine fumarate	mAChR	Neurological Disease Metabolic Disease Cancer
Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pK_i values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine Fumarate is used for the overactive bladder (OAB) .

HY-70053

Fesoterodine	mAChR	Neurological Disease Metabolic Disease
Fesoterodine is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pK_i values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine is used for the overactive bladder (OAB) .

HY-A0012

Darifenacin hydrobromide 5 Publications Verification UK-88525 hydrobromide	mAChR p38 MAPK Akt	Neurological Disease Metabolic Disease Cancer
Darifenacin (UK-88525) hydrobromide is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9. Darifenacin hydrobromide binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin hydrobromide can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin hydrobromide inhibits tumor growth in colorectal cancer cells and has anti-tumor effects .

HY-107653

J 104129 fumarate	mAChR	Neurological Disease
J 104129 fumarate is a selective and orally active muscarinic M3 antagonist with K_i values of 4.2 nM and 490 nM for M3 and M2, respectively. J 104129 fumarate antagonized ACh-induced bronchoconstriction. J 104129 fumarate has the potential for the research of obstructive airway disease .

HY-70053A

Fesoterodine L-mandelate	mAChR	Neurological Disease Metabolic Disease Cancer
Fesoterodine L-mandelate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pK_i values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine L-mandelate is used for the overactive bladder (OAB) .

HY-32067

Aceclidine Quinuclidin-3-yl acetate	mAChR	Cardiovascular Disease Neurological Disease
Aceclidine (Quinuclidin-3-yl acetate) is a modulator of *M3 muscarinic* acetylcholine receptor and a M1 receptor** agonist (EC₅₀: 40 μM). Aceclidine is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine has the potential for the research of disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia .

HY-32067A

Aceclidine hydrochloride Quinuclidin-3-yl acetate hydrochloride	mAChR	Neurological Disease
Aceclidine (Quinuclidin-3-yl acetate) hydrochloride is a modulator of *M3 muscarinic* acetylcholine receptor and a M1 receptor** agonist (EC₅₀: 40 μM). Aceclidine hydrochloride is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine hydrochloride has the potential for the research of disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia .

HY-108030

Bencycloquidium bromide	mAChR	Neurological Disease Inflammation/Immunology Cancer
Bencycloquidium bromide, a muscarinic M(3) receptor antagonist, is an anticholinergic compound that acts as an anticholinergic bronchodilator. Bencycloquidium bromide can be used in the study for rhinitis .

HY-A0012R

Darifenacin (hydrobromide) (Standard) UK-88525 (hydrobromide) (Standard)	mAChR p38 MAPK Akt	Neurological Disease Metabolic Disease Cancer
Darifenacin (hydrobromide) (Standard) is the analytical standard of Darifenacin (hydrobromide). This product is intended for research and analytical applications. Darifenacin (hydrobromide) is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9. Darifenacin (hydrobromide) binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin (hydrobromide) can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin (hydrobromide) inhibits tumor growth in colorectal cancer cells and has anti-tumor effects .

HY-A0030R

Fesoterodine (fumarate) (Standard)	mAChR	Neurological Disease Metabolic Disease Cancer
Fesoterodine (fumarate) (Standard) is the analytical standard of Fesoterodine (fumarate). This product is intended for research and analytical applications. Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine Fumarate is used for the overactive bladder (OAB) .

HY-107645

DAU 5884 hydrochloride	mAChR	Neurological Disease
DAU 5884 hydrochloride is a potent muscarinic M3 receptor antagonist. DAU 5884 hydrochloride inhibits methacholine-dependent effects on cell proliferation and muscle contractility .

HY-14825

Tarafenacin SVT-40776	mAChR	Neurological Disease
Tarafenacin(SVT-40776) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor.

HY-I0230

Solifenacin hydrochloride 3 Publications Verification YM905 hydrochloride	mAChR	Neurological Disease Cancer
Solifenacin hydrochloride (YM905 hydrochloride) is a muscarinic receptor antagonist, with pK_is of 7.6, 6.9 and 8.0 for M₁, M₂ and M₃ receptors, respectively.

HY-129826

J-104129	mAChR	Others
J-104129 is a selective and orally active muscarinic M3 receptor antagonist (K_i = 4.2 nM). J-104129 is effective in promoting bronchodilation .

HY-16489A

Terodiline hydrochloride	mAChR Calcium Channel	Neurological Disease
Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with K_bs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca ²⁺ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence .

HY-B0461

Trospium chloride	mAChR	Neurological Disease Cancer
Trospium chloride is an orally active, specific and competitive antagonist of muscarinic cholinergic receptors (mAChRs), with antimuscarinic activity. Trospium chloride binds to muscarinic receptors M1, M2 and M3 with high affinity, but not nicotinic, cholinergic receptors .

HY-A0002

Solifenacin Succinate 3 Publications Verification YM905	mAChR	Neurological Disease
Solifenacin Succinate (YM905) is a novel muscarinic receptor antagonist with pK_is of 7.6, 6.9 and 8.0 for M₁, M₂ and M₃ receptors, respectively.

HY-14825A

Tarafenacin D-tartrate SVT-40776 D-tartrate	mAChR	Neurological Disease
Tarafenacin D-tartrate (SVT-40776 D-tartrate) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor.

HY-A0034

Solifenacin 3 Publications Verification YM905 free base	mAChR	Neurological Disease Cancer
Solifenacin (YM905 free base) is a novel muscarinic receptor antagonist with pK_is of 7.6, 6.9 and 8.0 for M₁, M₂ and M₃ receptors, respectively.

HY-120418

L-687306	Others	Others
L-687306 is a high affinity muscarinic M1 receptor partial agonist with activity as a partial agonist of M1 receptors in rat ganglia and as a high affinity competitive antagonist at guinea pig cardiac M2 and ileal M3 muscarinic receptors, useful for studying the receptor reserve of muscarinic receptors.

HY-N7247

Thiochrome	mAChR	Metabolic Disease
Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective *M4 muscarinic* receptor of acetylcholine (ACh)** affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors .

HY-122510

Atropine oxide Atropine oxidation	Parasite	Neurological Disease
Atropine Oxide (Atropine oxidation), a derivative of Atropine, acts as a competitive antagonist to the muscarinic acetylcholine receptors M1, M2, M3, M4, and M5, and is utilized in the treatment of specific nerve agent and pesticide poisonings.

HY-107646

PD 102807	mAChR	Neurological Disease
PD 102807 is a *M4 muscarinic* receptor antagonist with an IC₅₀** of 90.7 nM. PD 102807 inhibits M1, M2, M3, M5 muscarinic receptor with IC₅₀s of 6558.7, 3440.7, 950.0, and 7411.7 nM, respectively . Antidyskinetic effect.

HY-122510A

Atropine oxide hydrochloride Atropine oxidation hydrochloride	mAChR
Atropine Oxide (Atropine oxidation) hydrochloride, a derivative of Atropine, acts as a competitive antagonist to the muscarinic acetylcholine receptors M1, M2, M3, M4, and M5, and is utilized in the treatment of specific nerve agent and pesticide poisonings .

HY-B0461R

Trospium chloride (Standard)	mAChR	Neurological Disease
Trospium (chloride) (Standard) is the analytical standard of Trospium (chloride). This product is intended for research and analytical applications. Trospium chloride is an orally active, specific and competitive antagonist of muscarinic cholinergic receptors (mAChRs), with antimuscarinic activity. Trospium chloride binds to muscarinic receptors M1, M2 and M3 with high affinity, but not nicotinic, cholinergic receptors .

HY-160888

ASP8302	mAChR	Others
ASP8302 is a positive allosteric modulator of muscarinic M3 Receptor. ASP8302 improves voiding efficiency and reduced residual urine volume in two voiding dysfunction models. ASP8302 can be used for research of underactive bladder .

HY-120329

Lu 26-046	mAChR	Others
Lu 26-046 is the agonist for muscarinic M1 receptor and M2 receptor and a weak antagonist for M3 receptor, with K_i of 0.51, 26 and 5 nM, respectively. Lu 26-046 exhibits specific stimulus property, that can be recognized by rats .

HY-A0034R

Solifenacin (Standard)	mAChR	Neurological Disease Cancer
Solifenacin (Standard) is the analytical standard of Solifenacin. This product is intended for research and analytical applications. Solifenacin (YM905 free base) is a novel muscarinic receptor antagonist with pK_is of 7.6, 6.9 and 8.0 for M₁, M₂ and M₃ receptors, respectively.

HY-163702

CHF-6550	Adrenergic Receptor mAChR	Inflammation/Immunology
CHF-6550 is an antagonist for muscarinic M3 receptor and an agonist for β2 adrenoceptor (MABA), with pK_i of 9.3 and 10.6, respectively. CHF-6550 exhibits good hepatocyte clearance in rat models and good pharmacokinetic characteristics in guinea pigs .

HY-A0002R

Solifenacin Succinate (Standard) YM905 (Standard)	mAChR	Neurological Disease Cancer
Solifenacin (Succinate) (Standard) is the analytical standard of Solifenacin (Succinate). This product is intended for research and analytical applications. Solifenacin Succinate (YM905) is a novel muscarinic receptor antagonist with pK_is of 7.6, 6.9 and 8.0 for M₁, M₂ and M₃ receptors, respectively.

HY-N7247R

Thiochrome (Standard)	mAChR	Metabolic Disease
Thiochrome (Standard) is the analytical standard of Thiochrome. This product is intended for research and analytical applications. Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors .

Cat. No.	Product Name	Target	Research Area

HY-P4156

VLVNTFCDSCIPKTYWNLGY TFA	mAChR	Neurological Disease
VLVNTFCDSCIPKTYWNLGY TFA is an antigenic peptide of M3 muscarinic receptor (M3R). VLVNTFCDSCIPKTYWNLGY TFA can be used in ELISA .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81142

	Muscarinic Acetylcholine receptor M3 Antibody muscarinic Acetylcholine receptor M3; cholinergic receptor, muscarinic 3; CHRM 3; CHRM3; HM 3; HM3; HM3; EGBRS; M3 muscarinic receptor; muscarinic 3; M3 muscarinic acetylcholine receptor; ACM3_HUMAN; muscarinic receptor M3; muscarinic cholinergic M3 receptor; muscarinic M3 receptor; Acetylcholine receptor(M3).	WB	Human
	Muscarinic Acetylcholine receptor M3 Antibody is an unconjugated, approximately 66 kDa, rabbit-derived, anti-Muscarinic Acetylcholine receptor M3 monoclonal antibody. Muscarinic Acetylcholine receptor M3 Antibody can be used for: WB expriments in human background without labeling.

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Cat. No.	Product Name		Classification

HY-128855

Talsaclidine		Alkynes
Talsaclidine is a muscarinic agonist with preferential neuron-stimulating properties. Talsaclidine is a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes . Talsaclidine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-120329

Lu 26-046		Alkynes
Lu 26-046 is the agonist for muscarinic M1 receptor and M2 receptor and a weak antagonist for M3 receptor, with K_i of 0.51, 26 and 5 nM, respectively. Lu 26-046 exhibits specific stimulus property, that can be recognized by rats .

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muscarinic M3

Inhibitors & Agonists

Peptides

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