2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. mAChR Calcium Channel
  4. Terodiline hydrochloride

Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca2+ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence.

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Terodiline hydrochloride Chemical Structure

Terodiline hydrochloride Chemical Structure

CAS No. : 7082-21-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Terodiline hydrochloride:

Terodiline hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All mAChR Isoform Specific Products:

View All Isoforms
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

View All Calcium Channel Isoform Specific Products:

View All Isoforms
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca2+ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence[1].

IC50 & Target

mAChR[1]
Ca2+ channel[1]
In Vivo

Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fmale or male Hartley guinea pigs (200-600 g)[1]
Dosage: 80 mg/kg
Administration: Administered S.C.
Result: Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.
Molecular Weight

317.90

Formula

C20H28ClN
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(NC(C)(C)C)CC(C1=CC=CC=C1)C2=CC=CC=C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (125.83 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1456 mL 15.7282 mL 31.4564 mL
5 mM 0.6291 mL 3.1456 mL 6.2913 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1456 mL 15.7282 mL 31.4564 mL 78.6411 mL
5 mM 0.6291 mL 3.1456 mL 6.2913 mL 15.7282 mL
10 mM 0.3146 mL 1.5728 mL 3.1456 mL 7.8641 mL
15 mM 0.2097 mL 1.0485 mL 2.0971 mL 5.2427 mL
20 mM 0.1573 mL 0.7864 mL 1.5728 mL 3.9321 mL
25 mM 0.1258 mL 0.6291 mL 1.2583 mL 3.1456 mL
30 mM 0.1049 mL 0.5243 mL 1.0485 mL 2.6214 mL
40 mM 0.0786 mL 0.3932 mL 0.7864 mL 1.9660 mL
50 mM 0.0629 mL 0.3146 mL 0.6291 mL 1.5728 mL
60 mM 0.0524 mL 0.2621 mL 0.5243 mL 1.3107 mL
80 mM 0.0393 mL 0.1966 mL 0.3932 mL 0.9830 mL
100 mM 0.0315 mL 0.1573 mL 0.3146 mL 0.7864 mL
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Terodiline hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Terodiline7082-21-5mAChRCalcium ChannelMuscarinic acetylcholine receptorCa2+ channelsCa channelsmuscarinicreceptorCa2+blockerurinaryfrequencyurgeincontinenceantianginalInhibitorinhibitorinhibit

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