2. Induced Disease Models Products GPCR/G Protein Neuronal Signaling Immunology/Inflammation Metabolic Enzyme/Protease
  3. Immunology and Inflammatory Disease Models Digestive System Disease Models Histamine Receptor Endogenous Metabolite
  4. Gastrointestinal Inflammation and Ulcer Models Gastrointestinal Disease Models
  5. Gastric Ulcer Models Duodenal Ulcer Models
  6. Histamine

Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter.

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Histamine Chemical Structure

Histamine Chemical Structure

CAS No. : 51-45-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Based on 9 publication(s) in Google Scholar

Other Forms of Histamine:

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter.

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Histamine can be used in animal modeling to create gastrointestinal ulcer models. After intravenous injection, the maximum concentration and AUC of histamine in liver and liver tumor tissues are higher than those in subcutaneous tissues[1].

Induction of Gastrointestinal Ulcer[2]
Background
Histamine can cause increased gastric acid secretion, decreased mucus production, reflux of pancreatic juice, poor gastric blood flow, and thus gastric ulcers. Stress can cause increased gastrointestinal motility, making the gastric folds more susceptible to damage when exposed to acid.
Specific Mmodeling Methods
Guinea Pig: male • albino • Administration: 5 mg/kg • i.p. • single dose
Note
(1) No eating or drinking is allowed 24 hours before the experiment.
(2) The animals are sacrificed 2 hours after histamine injection, and treated with 1% formalin to check for gastric ulcers.
Modeling Indicators
The ulcers were punctate or elongated. After the model was dissected, the ulcer index (the sum of the lengths of the lesions) was measured under a microscope to be 3.4 mm.
Correlated Product(s): Serotonin (HY-B1473A); Reserpine (HY-N0480)
Opposite Product(s): Cimetidine (HY-14289)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

111.15

Formula

C5H9N3
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

NCCC1=CN=CN1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (1124.63 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.9970 mL 44.9851 mL 89.9701 mL
5 mM 1.7994 mL 8.9970 mL 17.9940 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (899.70 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.99%

COA (245 KB) HNMR (227 KB) RP-HPLC (241 KB) MS (176 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 8.9970 mL 44.9851 mL 89.9701 mL 224.9253 mL
5 mM 1.7994 mL 8.9970 mL 17.9940 mL 44.9851 mL
10 mM 0.8997 mL 4.4985 mL 8.9970 mL 22.4925 mL
15 mM 0.5998 mL 2.9990 mL 5.9980 mL 14.9950 mL
20 mM 0.4499 mL 2.2493 mL 4.4985 mL 11.2463 mL
25 mM 0.3599 mL 1.7994 mL 3.5988 mL 8.9970 mL
30 mM 0.2999 mL 1.4995 mL 2.9990 mL 7.4975 mL
40 mM 0.2249 mL 1.1246 mL 2.2493 mL 5.6231 mL
50 mM 0.1799 mL 0.8997 mL 1.7994 mL 4.4985 mL
60 mM 0.1500 mL 0.7498 mL 1.4995 mL 3.7488 mL
80 mM 0.1125 mL 0.5623 mL 1.1246 mL 2.8116 mL
100 mM 0.0900 mL 0.4499 mL 0.8997 mL 2.2493 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Histamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Histamine51-45-6ErgamineHistamine ReceptorEndogenous MetaboliteInhibitorinhibitorinhibit

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