2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. VU0238441

VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively.

For research use only. We do not sell to patients.

VU0238441 Chemical Structure

VU0238441 Chemical Structure

CAS No. : 85511-68-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid
5 mg USD 50 In-stock
10 mg USD 70 In-stock
50 mg USD 140 In-stock
100 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

VU0238441 Related Antibodies

Top Publications Citing Use of Products

View All mAChR Isoform Specific Products:

View All Isoforms
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • Biological Activity

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  • Customer Review

Description

VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2].

IC50 & Target

EC50: 3.2 μM (M1), 2.8 μM (M2), 2.2 μM (M3), 2.1 μM (M5) and >10 μM (M4)[1]
In Vitro

VU0238441 is an analogue of VU0119498[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VU0238441 Related Antibodies
Molecular Weight

339.70

Formula

C16H9ClF3NO2
CAS No.
Appearance

Solid

Color

Brown to red

SMILES

O=C1N(CC2=CC=C(C(F)(F)F)C=C2)C3=C(C=CC=C3Cl)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (367.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9438 mL 14.7189 mL 29.4377 mL
5 mM 0.5888 mL 2.9438 mL 5.8875 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9438 mL 14.7189 mL 29.4377 mL 73.5943 mL
5 mM 0.5888 mL 2.9438 mL 5.8875 mL 14.7189 mL
10 mM 0.2944 mL 1.4719 mL 2.9438 mL 7.3594 mL
15 mM 0.1963 mL 0.9813 mL 1.9625 mL 4.9063 mL
20 mM 0.1472 mL 0.7359 mL 1.4719 mL 3.6797 mL
25 mM 0.1178 mL 0.5888 mL 1.1775 mL 2.9438 mL
30 mM 0.0981 mL 0.4906 mL 0.9813 mL 2.4531 mL
40 mM 0.0736 mL 0.3680 mL 0.7359 mL 1.8399 mL
50 mM 0.0589 mL 0.2944 mL 0.5888 mL 1.4719 mL
60 mM 0.0491 mL 0.2453 mL 0.4906 mL 1.2266 mL
80 mM 0.0368 mL 0.1840 mL 0.3680 mL 0.9199 mL
100 mM 0.0294 mL 0.1472 mL 0.2944 mL 0.7359 mL
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VU0238441 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU023844185511-68-8VU 0238441VU-0238441mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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