SRT3657

Cat. No.: HY-136094: FAQs
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SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.

For research use only. We do not sell to patients.

SRT3657 Chemical Structure

CAS No. : 1383551-17-4

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Biological Activity
Purity & Documentation
References
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Description

SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect^[1].

IC₅₀ & Target

SIRT1^[1]

In Vivo

SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice^[1].
SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments^[1].
SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult double-transgenic CK-p25 mice (3-month-old)^[1]
Dosage:	30 mg/kg
Administration:	Oral gavage, daily, for 6 weeks
Result:	Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals.

Molecular Weight

774.97

Formula

C₄₀H₅₄N₈O₆S

CAS No.

1383551-17-4

SMILES

O=C(N1CCC(OCC2=CN=C(SC(C3=CC=CC=C3NC(C4=NC(CCCC)=NC(NCCN(C(OC(C)(C)C)=O)C)=C4)=O)=N5)C5=C2)CC1)OC(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gräff J, et al. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci. 2013 May 22;33(21):8951-60. [Content Brief]

SRT3657 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRT36571383551-17-4SRT 3657SRT-3657SirtuinSIRT1neuroprotectivecaloricrestrictionsynapticneuronallossneurodegenerationmemoryimpairmentsInhibitorinhibitorinhibit

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