Trypsinogen

Cat. No.: HY-P2823: FAQs
Data Sheet Handling Instructions

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Trypsinogen, a proenzyme synthesized in the pancreas, is activated to form trypsin by enterokinase upon reaching the small intestine lumen, where it opens a hexapeptide bond at the Lys6 - Ile7 junction, leading to the production of the active enzyme. This single polypeptide chain, composed of 229 amino acids and stabilized by six disulfide bridges, further autocatalytically converts additional trypsinogen into trypsin, which is initially present as β-trypsin before undergoing autolysis at the Lys131 - Ser132 site to form α-trypsin. As a serine protease, trypsin features His46 and Ser183 at its active site and exhibits optimal enzymatic activity at a pH range of 7 to 9.

For research use only. We do not sell to patients.

Trypsinogen Chemical Structure

CAS No. : 9002-08-8

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Description	Trypsinogen, a proenzyme synthesized in the pancreas, is activated to form trypsin by enterokinase upon reaching the small intestine lumen, where it opens a hexapeptide bond at the Lys6 - Ile7 junction, leading to the production of the active enzyme. This single polypeptide chain, composed of 229 amino acids and stabilized by six disulfide bridges, further autocatalytically converts additional trypsinogen into trypsin, which is initially present as β-trypsin before undergoing autolysis at the Lys131 - Ser132 site to form α-trypsin. As a serine protease, trypsin features His46 and Ser183 at its active site and exhibits optimal enzymatic activity at a pH range of 7 to 9.
CAS No.	9002-08-8
SMILES	[Trypsinogen]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (239 KB) Handling Instructions (2659 KB)

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Trypsinogen9002-08-8OthersInhibitorinhibitorinhibit

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