2. MAPK/ERK Pathway Stem Cell/Wnt Apoptosis PI3K/Akt/mTOR
  3. ERK TNF Receptor Akt
  4. UNC10245380

UNC10245380 is a CIB1 inhibitor with an IC50 value of 8 μM. Additionally, UNC10245380 inhibits the phosphorylation of AKT and ERK and upregulates the expression of TRAIL-R1/D5. UNC10245380 selectively induces cell death in CIB1-dependent cancer cells, highlighting its potential utility in the development of CIB1-targeted probes and cancer research.

For research use only. We do not sell to patients.

UNC10245380 Chemical Structure

UNC10245380 Chemical Structure

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UNC10245380 Related Antibodies

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Description

UNC10245380 is a CIB1 inhibitor with an IC50 value of 8 μM. Additionally, UNC10245380 inhibits the phosphorylation of AKT and ERK and upregulates the expression of TRAIL-R1/D5. UNC10245380 selectively induces cell death in CIB1-dependent cancer cells, highlighting its potential utility in the development of CIB1-targeted probes and cancer research[1][2].

IC50 & Target

IC50 = 8 μM (Calcium and Integrin Binding Protein 1 (CIB1))[1]
In Vitro

UNC10245380 (30 μM, 24 h) exhibits specific cytotoxic activity in CIB1 depletion-sensitive triple-negative breast cancer (TNBC) cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UNC10245380 Related Antibodies

Cell Viability Assay[1]

Cell Line: CIB1 depletion-sensitive (MDA461, MDA468) and -insensitive (MDA231) TNBC cells
Concentration: 30 μM
Incubation Time: 24 h
Result: Showed significant cell killing activity in both CIB1-depletion-sensitive (MDA-MB-461, and MDA-MB-468) cell lines, but showed no activity in the CIB1-depletion-insensitive (MDA-MB-231) cell line.

Western Blot Analysis[1]

Cell Line: MDA-MB-468, MDA-MB-436, MDA-MB-231, BT-549 cells
Concentration: 30 μM
Incubation Time: 24 h
Result: Inhibited AKT and ERK phosphorylation in CIB1 depletion-sensitive cell lines, but not insensitive cell lines.
Molecular Weight

578.12

Formula

C30H32ClN5O3S
SMILES

ClC1=C(CNC(C2CCC(CC2)CC3C(C4=CC=CC=C4N=C3SCC(NC5=NNC(C)=C5)=O)=O)=O)C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UNC10245380 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC10245380UNC 10245380UNC-10245380ERKTNF ReceptorAktExtracellular signal regulated kinasesTumor Necrosis Factor ReceptorTNFRPKBProtein kinase BTNBC cellsAnti-cancer activityCancerInhibitorinhibitorinhibit

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