2. Metabolic Enzyme/Protease
  3. Xanthine Oxidase
  4. Xanthine oxidase-IN-4

Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC50 of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research.

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Xanthine oxidase-IN-4 Chemical Structure

Xanthine oxidase-IN-4 Chemical Structure

CAS No. : 2642137-96-8

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Xanthine oxidase-IN-4 Related Antibodies

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Description

Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC50 of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research[1].

IC50 & Target

IC50: 0.039 μM (xanthine oxidase)[1]
In Vitro

Xanthine oxidase-IN-4 (compound 19a) (1 nM-10 μM, 15 min) exhibits a strong XO inhibitory potency, with an IC50 of 0.039 μM, and Ki of 0.0037 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Xanthine oxidase-IN-4 Related Antibodies
In Vivo

Xanthine oxidase-IN-4 (compound 19a) (SD rats, 10 mg/kg, Intragastrically, once) significantly reduces the serum concentration of uric acid[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (Six weeks, male, 180-200g, six groups)[1]
Dosage: 10 mg/kg
Administration: Intragastrically, once
Result: Significantly reduced the serum concentration of uric acid, with AUC (uric acid, 1-5 h) of 44.3%.
Molecular Weight

295.30

Formula

C15H13N5O2
CAS No.
SMILES

N#CC1=CC(C2=NC=C3C(NNC3=O)=N2)=CC=C1OC(C)C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Xanthine oxidase-IN-4 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

Xanthine oxidase-IN-42642137-96-8Xanthine OxidaseXOOrally activeHyperuricemiaGoutInhibitorinhibitorinhibit

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