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  4. (2R,3S)-Azelaprag

(2R,3S)-Azelaprag  (Synonyms: (2R,3S)-AMG 986)

Cat. No.: HY-167712
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(2R,3S)-Azelaprag ((2R,3S)-AMG 986) is an Apelin receptor agonist with an EC50 of 0.012 µM for Apelin receptors, and it is utilized in the treatment of various conditions such as heart failure, atherosclerosis, obesity, diabetes mellitus, amyotrophic lateral sclerosis, coronary artery disease, hypertension, stroke, and myocardial infarction.

For research use only. We do not sell to patients.

(2R,3S)-Azelaprag Chemical Structure

(2R,3S)-Azelaprag Chemical Structure

CAS No. : 2049979-31-7

Size Price Stock Quantity
5 mg USD 630 In-stock
10 mg USD 1050 In-stock
25 mg USD 2216 In-stock
50 mg USD 3550 In-stock
100 mg USD 5680 In-stock
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500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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(2R,3S)-Azelaprag Related Antibodies

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Description

(2R,3S)-Azelaprag ((2R,3S)-AMG 986) is an Apelin receptor agonist with an EC50 of 0.012 µM for Apelin receptors, and it is utilized in the treatment of various conditions such as heart failure, atherosclerosis, obesity, diabetes mellitus, amyotrophic lateral sclerosis, coronary artery disease, hypertension, stroke, and myocardial infarction.

Molecular Weight

523.61

Formula

C25H29N7O4S
CAS No.
SMILES

O=S(NC1=NN=C(C2=CN=CC(C)=C2)N1C(C(OC)=CC=C3)=C3OC)([C@H](C)[C@H](C4=NC=C(C)C=N4)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (190.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9098 mL 9.5491 mL 19.0982 mL
5 mM 0.3820 mL 1.9098 mL 3.8196 mL
View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9098 mL 9.5491 mL 19.0982 mL 47.7455 mL
5 mM 0.3820 mL 1.9098 mL 3.8196 mL 9.5491 mL
10 mM 0.1910 mL 0.9549 mL 1.9098 mL 4.7745 mL
15 mM 0.1273 mL 0.6366 mL 1.2732 mL 3.1830 mL
20 mM 0.0955 mL 0.4775 mL 0.9549 mL 2.3873 mL
25 mM 0.0764 mL 0.3820 mL 0.7639 mL 1.9098 mL
30 mM 0.0637 mL 0.3183 mL 0.6366 mL 1.5915 mL
40 mM 0.0477 mL 0.2387 mL 0.4775 mL 1.1936 mL
50 mM 0.0382 mL 0.1910 mL 0.3820 mL 0.9549 mL
60 mM 0.0318 mL 0.1592 mL 0.3183 mL 0.7958 mL
80 mM 0.0239 mL 0.1194 mL 0.2387 mL 0.5968 mL
100 mM 0.0191 mL 0.0955 mL 0.1910 mL 0.4775 mL
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(2R,3S)-Azelaprag Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(2R,3S)-Azelaprag2049979-31-7(2R,3S)-AMG 986OthersInhibitorinhibitorinhibit

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