2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. 4-Chlorophenylguanidine hydrochloride

4-Chlorophenylguanidine hydrochloride 

Cat. No.: HY-100939 Purity: 99.07%
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4-Chlorophenylguanidine hydrochloride is a potent ASIC3 positive allosteric modulator and reverses the effects of ASIC3 desensitization. 4-Chlorophenylguanidine hydrochloride influences ASIC3 activity through directly activating the channel and increasing proton sensitivity. 4-Chlorophenylguanidine hydrochloride offers a chemical backbone for the design of new ASIC3 ligands to study ASIC3 in vivo.

For research use only. We do not sell to patients.

4-Chlorophenylguanidine hydrochloride Chemical Structure

4-Chlorophenylguanidine hydrochloride Chemical Structure

CAS No. : 14279-91-5

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Based on 1 publication(s) in Google Scholar

4-Chlorophenylguanidine hydrochloride Related Antibodies

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Description

4-Chlorophenylguanidine hydrochloride is a potent ASIC3 positive allosteric modulator and reverses the effects of ASIC3 desensitization. 4-Chlorophenylguanidine hydrochloride influences ASIC3 activity through directly activating the channel and increasing proton sensitivity. 4-Chlorophenylguanidine hydrochloride offers a chemical backbone for the design of new ASIC3 ligands to study ASIC3 in vivo[1].

Molecular Weight

206.07

Formula

C7H9Cl2N3
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

NC(NC1=CC=C(Cl)C=C1)=N.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (606.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8527 mL 24.2636 mL 48.5272 mL
5 mM 0.9705 mL 4.8527 mL 9.7054 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8527 mL 24.2636 mL 48.5272 mL 121.3180 mL
5 mM 0.9705 mL 4.8527 mL 9.7054 mL 24.2636 mL
10 mM 0.4853 mL 2.4264 mL 4.8527 mL 12.1318 mL
15 mM 0.3235 mL 1.6176 mL 3.2351 mL 8.0879 mL
20 mM 0.2426 mL 1.2132 mL 2.4264 mL 6.0659 mL
25 mM 0.1941 mL 0.9705 mL 1.9411 mL 4.8527 mL
30 mM 0.1618 mL 0.8088 mL 1.6176 mL 4.0439 mL
40 mM 0.1213 mL 0.6066 mL 1.2132 mL 3.0329 mL
50 mM 0.0971 mL 0.4853 mL 0.9705 mL 2.4264 mL
60 mM 0.0809 mL 0.4044 mL 0.8088 mL 2.0220 mL
80 mM 0.0607 mL 0.3033 mL 0.6066 mL 1.5165 mL
100 mM 0.0485 mL 0.2426 mL 0.4853 mL 1.2132 mL
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4-Chlorophenylguanidine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Chlorophenylguanidine14279-91-5Sodium ChannelNa channelsNa+ channelsAcid-sensing ion channel 3GuanidineNeuroscienceInhibitorinhibitorinhibit

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