2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. ERB-196

ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist.

For research use only. We do not sell to patients.

ERB-196 Chemical Structure

ERB-196 Chemical Structure

CAS No. : 550997-55-2

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5 mg USD 460 In-stock
10 mg USD 740 In-stock
25 mg USD 1560 In-stock
50 mg USD 2500 In-stock
100 mg USD 4000 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

ERB-196 Related Antibodies

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist.

IC50 & Target

ERβ[1]
In Vivo

ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist. ERB-196 significantly reduces histopathologic evidence of injury to the gastrointestinal mucosal surface (0.7±0.1 vs. 2.3±0.2 for control; p<0.05). The mucosal mass of 10-cm segments of small bowel mucosa shows better preservation of mucosal mass than control treatment (63±20 [ERB-196] vs. 31±24 [control]), but this difference fails to reach statistical significance (p<0.06). The administration of ERB-196 is highly effective in the prevention of lethality. Consistent with the neutropenic rat model, ERB-196 significantly increases survival when compare with vehicle control[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

279.27

Formula

C17H10FNO2
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

N#CC1=C2C=C(O)C=CC2=CC(C3=CC=C(O)C(F)=C3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Ethanol : 16 mg/mL (57.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5808 mL 17.9038 mL 35.8076 mL
5 mM 0.7162 mL 3.5808 mL 7.1615 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Animal Administration
[1]

The neutropenic rat model of pseudomonas sepsis are used in this study. For the survival study, ERB-196 (50 mg/kg; n=12) or vehicle control (n=8) is administered daily by orogastric feeding beginning on day 4 after the first dose of cyclophosphamide and continuing for 8 days. Animals are assessed clinically and pathologically by measuring daily body weight, body temperature, presence of bacteremia, circulating endotoxin levels, and pathologic evidence of damage to the gastrointestinal epithelium and liver by light microscopy and electron microscopy. Blood and tissue samples are serially diluted in sterile saline and incubated at 37°C on pseudomonas agar for quantitative assessment of bacterial concentrations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 3.5808 mL 17.9038 mL 35.8076 mL 89.5191 mL
5 mM 0.7162 mL 3.5808 mL 7.1615 mL 17.9038 mL
10 mM 0.3581 mL 1.7904 mL 3.5808 mL 8.9519 mL
15 mM 0.2387 mL 1.1936 mL 2.3872 mL 5.9679 mL
20 mM 0.1790 mL 0.8952 mL 1.7904 mL 4.4760 mL
25 mM 0.1432 mL 0.7162 mL 1.4323 mL 3.5808 mL
30 mM 0.1194 mL 0.5968 mL 1.1936 mL 2.9840 mL
40 mM 0.0895 mL 0.4476 mL 0.8952 mL 2.2380 mL
50 mM 0.0716 mL 0.3581 mL 0.7162 mL 1.7904 mL
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ERB-196 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERB-196550997-55-2WAY-202196ERB196ERB 196WAY202196WAY 202196Estrogen Receptor/ERRInhibitorinhibitorinhibit

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HY-19468
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