2. Immunology/Inflammation
  3. COX
  4. Firocoxib

Firocoxib  (Synonyms: ML 1785713)

Cat. No.: HY-14670 Purity: 99.92%
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Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC50 of 7.5 μM). Firocoxib has anti-inflammatory effects.

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Firocoxib Chemical Structure

Firocoxib Chemical Structure

CAS No. : 189954-96-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 94 In-stock
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10 mM * 1 mL in DMSO USD 94 In-stock
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5 mg USD 85 In-stock
10 mg USD 135 In-stock
25 mg USD 280 In-stock
50 mg USD 450 In-stock
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Firocoxib Related Antibodies

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Description

Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC50 of 7.5 μM). Firocoxib has anti-inflammatory effects[1].

IC50 & Target[1]

COX-2

0.13 μM (IC50)

COX-1

7.5 μM (IC50)

In Vitro

The COX-1:COX-2 selectivity ratios generally are established by comparing the IC50 for COX-1 to the IC50 for COX-2. The IC80 value more closely resembles the steady-state plasma drug concentration than does the IC50 value[1].
The selectivity ratio for Firocoxib based on the IC80 values is 121 (IC80 of 0.36 μM and 43.6 μM for COX-2 and COX-1, respectively), indicating that selectivity for COX-2 is not reduced at concentrations higher than the IC50. Notably, Firocoxib concentrations that yield 80% to 95% inhibition of COX-2 produce < 20% inhibition of COX-1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Firocoxib Related Antibodies
In Vivo

Firocoxib (0.75-1.5mg/kg; oral gavage; female domestic shorthair cats) treatment efficacious in attenuating fever when administered to cats 1 or 14 hours before LPS challenge[1].
Pharmacokinetic properties of Firocoxib are determined after i.v. (2 mg/kg) and oral (3 mg/kg) administration in male cats. Firocoxib has moderate to high oral bioavailability (54% to 70%), low plasma clearance (4.7 to 5.8 mL/min/kg), and an elimination half-life of 8.7 to 12.2 hours[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 14 healthy female domestic shorthair cats (11-15 months old, 2.9-3.9 kg) with lipopolysaccharide (LPS)[1]
Dosage: 0.75 mg/kg, 1.5 mg/kg
Administration: Oral gavage
Result: Was efficacious in attenuating fever when administered to cats 1 or 14 hours before LPS challenge.
Molecular Weight

336.40

Formula

C17H20O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1OC(C)(C)C(C2=CC=C(S(=O)(C)=O)C=C2)=C1OCC3CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 52 mg/mL (154.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9727 mL 14.8633 mL 29.7265 mL
5 mM 0.5945 mL 2.9727 mL 5.9453 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9727 mL 14.8633 mL 29.7265 mL 74.3163 mL
5 mM 0.5945 mL 2.9727 mL 5.9453 mL 14.8633 mL
10 mM 0.2973 mL 1.4863 mL 2.9727 mL 7.4316 mL
15 mM 0.1982 mL 0.9909 mL 1.9818 mL 4.9544 mL
20 mM 0.1486 mL 0.7432 mL 1.4863 mL 3.7158 mL
25 mM 0.1189 mL 0.5945 mL 1.1891 mL 2.9727 mL
30 mM 0.0991 mL 0.4954 mL 0.9909 mL 2.4772 mL
40 mM 0.0743 mL 0.3716 mL 0.7432 mL 1.8579 mL
50 mM 0.0595 mL 0.2973 mL 0.5945 mL 1.4863 mL
60 mM 0.0495 mL 0.2477 mL 0.4954 mL 1.2386 mL
80 mM 0.0372 mL 0.1858 mL 0.3716 mL 0.9290 mL
100 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
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Firocoxib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Firocoxib189954-96-9ML 1785713ML1785713ML-1785713COXCyclooxygenaseCOX-2anti-inflammatoryorallyLPSfeversafetyIC80Inhibitorinhibitorinhibit

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