2. Signaling Pathways
  3. Apoptosis
  4. Bcl-2 Family
  5. Mcl-1 Isoform
  6. Mcl-1 Inhibitor

Mcl-1 Inhibitor

Mcl-1 Inhibitors (51):

Cat. No. Product Name Effect Purity
  • HY-112859
    VU0661013
    		Inhibitor 98.45%
    VU661013 is a potent and selective MCL-1 inhibitor.
  • HY-15613
    Maritoclax
    		Inhibitor 99.97%
    Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM).
  • HY-15464
    (R)-(-)-Gossypol
    		Inhibitor 98.82%
    (R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
  • HY-101778
    ML311
    		Inhibitor 98.98%
    ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.
  • HY-129681
    MCL-1/BCL-2-IN-1
    		Inhibitor 99.86%
    MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 μM, respectively.
  • HY-12527
    Pyridoclax
    		Inhibitor 99.95%
    Pyridoclax is a potential Mcl-1 inhibitor.
  • HY-109184
    Murizatoclax
    		Inhibitor 98.85%
    Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a Ki of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer.
  • HY-16695
    MIM1
    		Inhibitor ≥98.0%
    MIM-1 is an inhibitor of myeloid cell factor 1 (Mcl-1).
  • HY-132307
    Mcl-1 inhibitor 6
    		Inhibitor 98.40%
    Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 (Mcl-1) protein inhibitor with a Kd of 0.23 nM and a Ki of 0.02 μM. Mcl-1 inhibitor 6 possesses superior selectivity over other Bcl-2 family members (Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w, Kd>10 μM). Mcl-1 inhibitor 6 is a potent antitumor agent.
  • HY-101533B
    AZD-5991 (S-enantiomer)
    		Inhibitor 99.83%
    AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay.
  • HY-10969A
    Obatoclax
    		Inhibitor ≥99.0%
    Obatoclax (GX15-070), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2. Obatoclax induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax has anti-cancer and broad-spectrum antiparasitic activity.
  • HY-12826
    IMB-XH1
    		Inhibitor ≥98.0%
    IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1). IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively.
  • HY-13408
    (+)-Apogossypol
    		Inhibitor
    (+)-Apogossypol is a pan-BCL-2 antagonist. (+)-Apogossypol binds to Mcl-1, Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 µM, respectively.
  • HY-16669
    Mcl1-IN-1
    		Inhibitor 98.40%
    Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC50=2.4 µM).
  • HY-128607
    Mcl1-IN-9
    		Inhibitor
    Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.
  • HY-19551
    Apogossypolone
    		Inhibitor
    Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-XL, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis and autophagy. Apogossypolone also has antifungal activity.
  • HY-101533A
    AZD-5991 Racemate
    		Inhibitor
    AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is a Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay.
  • HY-149086
    BPA-B9
    		Inhibitor
    BPA-B9 is a RXRα ligand and antagonist targeting the pRXRα-PLK1 interaction. BPA-B9 has excellent RXRα-binding affinity (KD=39.29 ± 1.12 nM). BPA-B9 inhibits the proliferation of cancer cells by inducing mitotic arrest and cell apoptosis.
  • HY-145825A
    (E)-Mcl-1 inhibitor 7
    		Inhibitor
    (E)-Mcl-1 inhibitor 7 (Example 34) is a Mcl-1 inhibitor (Ki: <1 nM, IC50: <500 nM). (E)-Mcl-1 inhibitor 7 can be used for research of cancers.
  • HY-133015
    Mcl-1 inhibitor 3
    		Inhibitor
    Mcl-1 inhibitor 3 (compound 1) is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an OPM-2 cell viability assay). Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.
    .